Zolmitriptan

Migraine, Cluster Headache, Liver + 1 more
Treatment
20 Active Studies for Zolmitriptan

What is Zolmitriptan

ZolmitriptanThe Generic name of this drug
Treatment SummaryZolmitriptan is an oral medication used to treat migraine headaches. It belongs to a group of drugs called triptans and is one of the most commonly prescribed medications for this condition. It is available in tablet and nasal spray form under the brand name Zomig. Zolmitriptan can be taken alone or with an NSAID, such as naproxen, to provide the best relief from migraine pain. It was approved by the FDA in 1997 and is considered the gold standard in treating acute migraine attacks.
Zomigis the brand name
image of different drug pills on a surface
Zolmitriptan Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Zomig
Zolmitriptan
1998
91

Effectiveness

How Zolmitriptan Affects PatientsZolmitriptan is a type of drug called a triptan, which works by activating certain serotonin receptors in the body. It can help reduce the pain of migraines, but can also cause adverse cardiovascular effects such as heart attack, stroke, or arrhythmia. Other side effects of taking Zolmitriptan include chest/throat/neck/jaw pain, tightness, and/or pressure, as well as the possibility of overusing the medication or having a reaction that affects the body's serotonin levels. People with phenylketonuria should be aware that ZOMIG-ZMT contains
How Zolmitriptan works in the bodyMigraines are severe headaches usually accompanied by nausea, light and sound sensitivity, and irritability. The exact cause is not known, but it is thought to involve both the nerves and blood vessels in the brain. Zolmitriptan is a medication used to treat migraines. It works by targeting certain nerve and blood vessels throughout the brain. This helps calm down the nerves and blood vessels, reducing the pain and other symptoms of migraine.

When to interrupt dosage

The recommended dosage of Zolmitriptan is contingent upon the diagnosed affliction, such as Cluster Headache, Migraine and moderate or extreme hepatic insufficiency. The measure varies as per the method of delivery (e.g. Spray, metered - Nasal or Tablet, multilayer, extended release - Oral) recorded in the table beneath.
Condition
Dosage
Administration
Cluster Headache
, 2.5 mg, 5.0 mg, 1.0 mg, 5.0 mg/pump actuation, 2.5 mg/pump actuation
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Nasal, Spray, metered, Spray, metered - Nasal, Tablet, film coated, Tablet, film coated - Oral, Spray, Nasal; Oral, Spray - Nasal; Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Spray - Nasal
Liver
, 2.5 mg, 5.0 mg, 1.0 mg, 5.0 mg/pump actuation, 2.5 mg/pump actuation
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Nasal, Spray, metered, Spray, metered - Nasal, Tablet, film coated, Tablet, film coated - Oral, Spray, Nasal; Oral, Spray - Nasal; Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Spray - Nasal
Migraine
, 2.5 mg, 5.0 mg, 1.0 mg, 5.0 mg/pump actuation, 2.5 mg/pump actuation
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Nasal, Spray, metered, Spray, metered - Nasal, Tablet, film coated, Tablet, film coated - Oral, Spray, Nasal; Oral, Spray - Nasal; Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Spray - Nasal
Migraine Disorders
, 2.5 mg, 5.0 mg, 1.0 mg, 5.0 mg/pump actuation, 2.5 mg/pump actuation
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Nasal, Spray, metered, Spray, metered - Nasal, Tablet, film coated, Tablet, film coated - Oral, Spray, Nasal; Oral, Spray - Nasal; Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Spray - Nasal

Warnings

Zolmitriptan has fourteen contraindications and should not be used in tandem with the conditions provided in the subsequent table.Zolmitriptan Contraindications
Condition
Risk Level
Notes
Coronary Artery Vasospasm
Do Not Combine
cardiac accessory conduction pathway disorders
Do Not Combine
Basilar-Type Migraine
Do Not Combine
history of stroke
Do Not Combine
Peripheral Vascular Disease
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Coronary Artery Disease
Do Not Combine
Transient Ischemic Attack
Do Not Combine
Wolff-Parkinson-White Syndrome
Do Not Combine
Hypertensive disease
Do Not Combine
Pulse Frequency
Do Not Combine
intestinal ischemia
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Zolmitriptan may interact with Pulse Frequency
There are 20 known major drug interactions with Zolmitriptan.
Common Zolmitriptan Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Zolmitriptan may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ethanol
Major
Zolmitriptan may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Methylene blue
Major
Zolmitriptan may increase the serotonergic activities of Methylene blue.
Mirtazapine
Major
Zolmitriptan may increase the serotonergic activities of Mirtazapine.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Zolmitriptan is combined with Oliceridine.
Zolmitriptan Toxicity & Overdose RiskTaking too much zolmitriptan may lead to serious side effects such as changes to the blood vessels and activation of serotonin receptors. Those who take a single dose of 50 mg may feel drowsy. It is recommended to provide medical support and symptom relief in cases of overdose.
image of a doctor in a lab doing drug, clinical research

Zolmitriptan Novel Uses: Which Conditions Have a Clinical Trial Featuring Zolmitriptan?

65 clinical trials are in progress to investigate the potential of Zolmitriptan in treating moderate to severe hepatic impairment, Cluster Headache and Migraine Disorders.
Condition
Clinical Trials
Trial Phases
Cluster Headache
3 Actively Recruiting
Phase 1, Phase 2
Migraine Disorders
0 Actively Recruiting
Liver
0 Actively Recruiting
Migraine
53 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1

Zolmitriptan Reviews: What are patients saying about Zolmitriptan?

5Patient Review
3/13/2009
Zolmitriptan for Migraine Headache
Extremely effective at treating migraines, but be aware that it can cause drowsiness. I find that I fall asleep and wake up without a migraine, but if I need to stay awake, the medicine makes me feel light-headed and dizzy.
4.7Patient Review
11/20/2019
Zolmitriptan for Migraine Headache
I'm mostly pleased with this product. If I don't take it the second I notice a migraine starting, it's not as effective.
4.3Patient Review
5/13/2008
Zolmitriptan for Migraine Headache
Zolmitriptan has helped me a lot by taking care of my migraines and their neurological symptoms. However, I do get headaches from the medication itself (although they're manageable), as well as some other side effects that can last around 24 hours. These include hot water making my skin tingle, mild dizziness, and generally feeling out-of-it.
4Patient Review
10/9/2010
Zolmitriptan for Migraine Headache
This drug has been effective in treating my headaches; however, the problem is that they tend to come back every day.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about zolmitriptan

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is zolmitriptan a narcotic drug?

"Zomig is a drug that is used to treat migraine pain, but it is not a narcotic."

Answered by AI

How long does zolmitriptan take to work?

"In patients who respond to treatment, Zomig is effective within one hour of taking the medication. Zomig works just as well no matter when it is taken during a migraine attack, but it is best to take it as soon as possible after the migraine begins."

Answered by AI

How does zolmitriptan make you feel?

"Zolmitriptan is a type of medication that is designed to specifically target serotonin receptors. By narrowing the blood vessels around the brain, it is able to effectively stop pain signals from being sent to the brain and also block the release of certain natural substances that can cause a range of symptoms associated with migraines including pain and nausea."

Answered by AI

What is zolmitriptan prescribed for?

"Zolmitriptan is a medication used to treat acute migraine headaches in adults. It is not effective in preventing migraine headaches or treating cluster headaches. Zolmitriptan works by targeting pain receptors in the brain to relieve the pain associated with migraines."

Answered by AI

Clinical Trials for Zolmitriptan

Have you considered Zolmitriptan clinical trials? We made a collection of clinical trials featuring Zolmitriptan, we think they might fit your search criteria.
Have you considered Zolmitriptan clinical trials? We made a collection of clinical trials featuring Zolmitriptan, we think they might fit your search criteria.
Have you considered Zolmitriptan clinical trials? We made a collection of clinical trials featuring Zolmitriptan, we think they might fit your search criteria.