Pregabalin

Seizures, Peripheral Nervous System Diseases, Generalized Anxiety Disorder + 9 more
Treatment
12 FDA approvals
20 Active Studies for Pregabalin

What is Pregabalin

PregabalinThe Generic name of this drug
Treatment SummaryPregabalin is a medication used to treat nerve pain, shingles pain, and fibromyalgia. It works by affecting the levels of a chemical called GABA, which is a neurotransmitter that helps with pain signals. The exact way that pregabalin works is not fully understood, but it is believed to bind to a subunit of voltage-dependent calcium channels in the brain. Pregabalin is sold under the brand name Lyrica and Lyrica CR (extended release). Using pregabalin irresponsibly or in large doses can cause dependence, particularly in people with a history of substance abuse.
Lyricais the brand name
image of different drug pills on a surface
Pregabalin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Lyrica
Pregabalin
2004
579

Approved as Treatment by the FDA

Pregabalin, also called Lyrica, is approved by the FDA for 12 uses which include Neuropathic Pain and Seizures .
Neuropathic Pain
Helps manage Neuropathic Pain
Seizures
Diabetic Neuralgia
Helps manage Diabetic Peripheral Neuropathic Pain (DPN)
Postherpetic Neuralgia
Neuropathic Pain
Helps manage Neuropathic Pain
Spinal Cord Injuries (SCI)
Helps manage Spinal Cord Injuries (SCI)
Diabetic Peripheral Neuropathic Pain (DPN)
Helps manage Diabetic Peripheral Neuropathic Pain (DPN)
Fibromyalgia (FM)
Helps manage Fibromyalgia (FM)
Partial-Onset Seizures
Spinal Cord Injury
Helps manage Spinal Cord Injuries (SCI)
Neuralgia, Postherpetic
Fibromyalgia
Helps manage Fibromyalgia (FM)

Effectiveness

How Pregabalin Affects PatientsPregabalin is structurally similar to gamma-aminobutyric acid (GABA) but does not bind to GABA receptors. Instead, it attaches itself to calcium channels in the brain which helps reduce the amount of pain signals that are sent out. It does not influence dopamine, serotonin, opiate receptors, sodium channels, or the enzyme cyclooxygenase.
How Pregabalin works in the bodyWe don't know exactly how pregabalin works, but it appears to bind to voltage-gated calcium channels in the central nervous system. This connection helps reduce the amount of excitatory neurotransmitters, like glutamate and norepinephrine, that are released. It also prevents the alpha2-delta subunit from being transported to the spinal dorsal horn. Pregabalin is related to GABA, but it does not bind directly to GABA or benzodiazepine receptors.

When to interrupt dosage

The advised dose of Pregabalin is contingent upon the declared ailment, such as Neuralgia, Fibromyalgia and Postherpetic Neuralgia. The measure can be seen in the table below, in accordance with the method of delivery (e.g. Capsule or Tablet, film coated, extended release).
Condition
Dosage
Administration
Vitamin B 12 Deficiency
, 50.0 mg, 25.0 mg, 75.0 mg, 100.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 225.0 mg, 20.0 mg/mL, 165.0 mg, 82.5 mg, 330.0 mg
, Oral, Capsule, Capsule - Oral, Solution - Oral, Solution, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release - Oral, Tablet, extended release
Neuropathic Pain
, 50.0 mg, 25.0 mg, 75.0 mg, 100.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 225.0 mg, 20.0 mg/mL, 165.0 mg, 82.5 mg, 330.0 mg
, Oral, Capsule, Capsule - Oral, Solution - Oral, Solution, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release - Oral, Tablet, extended release
Epilepsy
, 50.0 mg, 25.0 mg, 75.0 mg, 100.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 225.0 mg, 20.0 mg/mL, 165.0 mg, 82.5 mg, 330.0 mg
, Oral, Capsule, Capsule - Oral, Solution - Oral, Solution, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release - Oral, Tablet, extended release
No gastrointestinal absorption problems
, 50.0 mg, 25.0 mg, 75.0 mg, 100.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 225.0 mg, 20.0 mg/mL, 165.0 mg, 82.5 mg, 330.0 mg
, Oral, Capsule, Capsule - Oral, Solution - Oral, Solution, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release - Oral, Tablet, extended release
Neuralgia
, 50.0 mg, 25.0 mg, 75.0 mg, 100.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 225.0 mg, 20.0 mg/mL, 165.0 mg, 82.5 mg, 330.0 mg
, Oral, Capsule, Capsule - Oral, Solution - Oral, Solution, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release - Oral, Tablet, extended release
Spinal Cord Injury
, 50.0 mg, 25.0 mg, 75.0 mg, 100.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 225.0 mg, 20.0 mg/mL, 165.0 mg, 82.5 mg, 330.0 mg
, Oral, Capsule, Capsule - Oral, Solution - Oral, Solution, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release - Oral, Tablet, extended release
Neuralgia, Postherpetic
, 50.0 mg, 25.0 mg, 75.0 mg, 100.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 225.0 mg, 20.0 mg/mL, 165.0 mg, 82.5 mg, 330.0 mg
, Oral, Capsule, Capsule - Oral, Solution - Oral, Solution, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release - Oral, Tablet, extended release
Seizures
, 50.0 mg, 25.0 mg, 75.0 mg, 100.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 225.0 mg, 20.0 mg/mL, 165.0 mg, 82.5 mg, 330.0 mg
, Oral, Capsule, Capsule - Oral, Solution - Oral, Solution, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release - Oral, Tablet, extended release
Generalized Anxiety Disorder
, 50.0 mg, 25.0 mg, 75.0 mg, 100.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 225.0 mg, 20.0 mg/mL, 165.0 mg, 82.5 mg, 330.0 mg
, Oral, Capsule, Capsule - Oral, Solution - Oral, Solution, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release - Oral, Tablet, extended release
Diabetic Neuralgia
, 50.0 mg, 25.0 mg, 75.0 mg, 100.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 225.0 mg, 20.0 mg/mL, 165.0 mg, 82.5 mg, 330.0 mg
, Oral, Capsule, Capsule - Oral, Solution - Oral, Solution, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release - Oral, Tablet, extended release
Fibromyalgia
, 50.0 mg, 25.0 mg, 75.0 mg, 100.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 225.0 mg, 20.0 mg/mL, 165.0 mg, 82.5 mg, 330.0 mg
, Oral, Capsule, Capsule - Oral, Solution - Oral, Solution, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release - Oral, Tablet, extended release
Peripheral Nervous System Diseases
, 50.0 mg, 25.0 mg, 75.0 mg, 100.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 225.0 mg, 20.0 mg/mL, 165.0 mg, 82.5 mg, 330.0 mg
, Oral, Capsule, Capsule - Oral, Solution - Oral, Solution, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release - Oral, Tablet, extended release

Warnings

Pregabalin Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Pregabalin may interact with Pulse Frequency
There are 20 known major drug interactions with Pregabalin.
Common Pregabalin Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Pregabalin may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ethanol
Major
Pregabalin may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Pregabalin is combined with Hydroxyzine.
Lorazepam
Major
The risk or severity of adverse effects can be increased when Pregabalin is combined with Lorazepam.
Mobocertinib
Major
The risk or severity of QTc prolongation can be increased when Pregabalin is combined with Mobocertinib.
Pregabalin Toxicity & Overdose RiskPregabalin has been linked to a range of side effects affecting the central nervous system and cognition, such as dizziness, balance problems, confusion, sleepiness, tremors, difficulty concentrating, tiredness, and euphoria. When taken in high doses (up to 11,500 mg), the most common symptoms of overdose include sleepiness, confusion, restlessness, agitation, depression, and seizures. There is no antidote for pregabalin overdose, so general supportive care should be given. In severe cases, unabsorbed pregabalin may be eliminated with methods such as gastric lavage or emesis, or
image of a doctor in a lab doing drug, clinical research

Pregabalin Novel Uses: Which Conditions Have a Clinical Trial Featuring Pregabalin?

111 active trials are currently in progress to investigate the potential of Pregabalin for alleviating Peripheral Neuropathy, Postherpetic Neuralgia and Gastrointestinal Absorption Difficulties.
Condition
Clinical Trials
Trial Phases
Peripheral Nervous System Diseases
2 Actively Recruiting
Not Applicable
Generalized Anxiety Disorder
2 Actively Recruiting
Not Applicable
Epilepsy
0 Actively Recruiting
Vitamin B 12 Deficiency
0 Actively Recruiting
Diabetic Neuralgia
4 Actively Recruiting
Phase 2, Phase 3
Fibromyalgia
0 Actively Recruiting
No gastrointestinal absorption problems
0 Actively Recruiting
Seizures
4 Actively Recruiting
Phase 3, Phase 2
Neuralgia
0 Actively Recruiting
Neuralgia, Postherpetic
0 Actively Recruiting
Spinal Cord Injury
52 Actively Recruiting
Not Applicable, Phase 4, Phase 2, Early Phase 1, Phase 1
Neuropathic Pain
5 Actively Recruiting
Not Applicable, Phase 1, Phase 2

Pregabalin Reviews: What are patients saying about Pregabalin?

5Patient Review
5/12/2022
Pregabalin for Nerve Pain from Spinal Cord Injury
I've been dealing with pain from my L1-L3 fracture for 40 years, and this is the first time I've had medication that's really helped. It's allowed me to get off of heroin and finally live a somewhat normal life. The weight gain and clumsiness are unfortunate side effects, but they're worth it to be able to function without constant pain.
5Patient Review
6/1/2022
Pregabalin for Neuropathic Pain
Without this medication, I would be unable to walk due to the severe neuropathy from diabetes that I have. This has been a lifesaver for me, allowing me to live relatively normally despite my chronic condition.
5Patient Review
5/12/2022
Pregabalin for Nerve Pain from Spinal Cord Injury
I've been dealing with a lot of pain for 40 years, ever since I fractured my L1-L3 vertebrae. I'm currently taking 300 mg of Pregabalin, 2 15 mg OxyContin, and 1 1mg alprozolam. These have finally helped me manage the pain and live a relatively normal life. Yes, there are some side effects like weight gain and clumsiness, but they're nothing compared to the alternative of living in constant pain.
5Patient Review
5/19/2022
Pregabalin for Neuropathic Pain
After my stroke, I was left with intense neuropathic pain. This medication has been a godsend in terms of relief, though I find that the effect wears off after a while. Still, it's better than nothing.
5Patient Review
6/1/2022
Pregabalin for Neuropathic Pain
This medication has been integral to me being able to walk, due to the severe neuropathy I experience from diabetes and multiple foot surgeries.
View All Reviews
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Patient Q&A Section about pregabalin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is pregabalin for mental health?

"Pregabalin is a drug that is related to the brain chemical GABA, which has a calming effect. Pregabalin reduces the release of brain chemicals that have a stimulating effect and can help with anxiety."

Answered by AI

What does pregabalin do to the nerves?

"Pregabalin is a medication used to treat seizures. It works by reducing the number of pain signals sent out by damaged nerves in the body."

Answered by AI

What is pregabalin used for?

"Pregabalin can help relieve certain types of nerve pain. It is typically used to treat conditions such as epilepsy, anxiety, and diabetic nerve pain. However, it can also be effective in treating nerve pain caused by other conditions such as shingles or an injury."

Answered by AI

Is pregabalin good for sleep?

"Treatment with pregabalin has been shown to improve all forms of insomnia and lead to reduced functional impairment and improved quality of life."

Answered by AI

Clinical Trials for Pregabalin

Have you considered Pregabalin clinical trials? We made a collection of clinical trials featuring Pregabalin, we think they might fit your search criteria.
Have you considered Pregabalin clinical trials? We made a collection of clinical trials featuring Pregabalin, we think they might fit your search criteria.
Have you considered Pregabalin clinical trials? We made a collection of clinical trials featuring Pregabalin, we think they might fit your search criteria.
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