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What is Pregabalin
PregabalinThe Generic name of this drug
Treatment SummaryPregabalin is a medication used to treat nerve pain, shingles pain, and fibromyalgia. It works by affecting the levels of a chemical called GABA, which is a neurotransmitter that helps with pain signals. The exact way that pregabalin works is not fully understood, but it is believed to bind to a subunit of voltage-dependent calcium channels in the brain. Pregabalin is sold under the brand name Lyrica and Lyrica CR (extended release). Using pregabalin irresponsibly or in large doses can cause dependence, particularly in people with a history of substance abuse.
Lyricais the brand name
Pregabalin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Lyrica
Pregabalin
2004
579
Approved as Treatment by the FDA
Pregabalin, also called Lyrica, is approved by the FDA for 6 uses which include Postherpetic Neuralgia and Neuropathic Pain .Postherpetic Neuralgia
Neuropathic Pain
Helps manage Neuropathic Pain
Spinal Cord Injury
Helps manage Spinal Cord Injuries (SCI)
Seizures
Fibromyalgia
Helps manage Fibromyalgia (FM)
Diabetic Neuralgia
Helps manage Diabetic Peripheral Neuropathic Pain (DPN)
Effectiveness
How Pregabalin Affects PatientsPregabalin is structurally similar to gamma-aminobutyric acid (GABA) but does not bind to GABA receptors. Instead, it attaches itself to calcium channels in the brain which helps reduce the amount of pain signals that are sent out. It does not influence dopamine, serotonin, opiate receptors, sodium channels, or the enzyme cyclooxygenase.
How Pregabalin works in the bodyWe don't know exactly how pregabalin works, but it appears to bind to voltage-gated calcium channels in the central nervous system. This connection helps reduce the amount of excitatory neurotransmitters, like glutamate and norepinephrine, that are released. It also prevents the alpha2-delta subunit from being transported to the spinal dorsal horn. Pregabalin is related to GABA, but it does not bind directly to GABA or benzodiazepine receptors.
When to interrupt dosage
The advised dose of Pregabalin is contingent upon the declared ailment, such as Neuralgia, Fibromyalgia and Postherpetic Neuralgia. The measure can be seen in the table below, in accordance with the method of delivery (e.g. Capsule or Tablet, film coated, extended release).Condition
Dosage
Administration
No gastrointestinal absorption problems
, 50.0 mg, 25.0 mg, 75.0 mg, 100.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 225.0 mg, 20.0 mg/mL, 165.0 mg, 82.5 mg, 330.0 mg
, Oral, Capsule, Capsule - Oral, Solution - Oral, Solution, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release - Oral, Tablet, extended release
Neuropathic Pain
, 50.0 mg, 25.0 mg, 75.0 mg, 100.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 225.0 mg, 20.0 mg/mL, 165.0 mg, 82.5 mg, 330.0 mg
, Oral, Capsule, Capsule - Oral, Solution - Oral, Solution, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release - Oral, Tablet, extended release
Vitamin B12 Deficiency
, 50.0 mg, 25.0 mg, 75.0 mg, 100.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 225.0 mg, 20.0 mg/mL, 165.0 mg, 82.5 mg, 330.0 mg
, Oral, Capsule, Capsule - Oral, Solution - Oral, Solution, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release - Oral, Tablet, extended release
Epilepsies
, 50.0 mg, 25.0 mg, 75.0 mg, 100.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 225.0 mg, 20.0 mg/mL, 165.0 mg, 82.5 mg, 330.0 mg
, Oral, Capsule, Capsule - Oral, Solution - Oral, Solution, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release - Oral, Tablet, extended release
Diabetic Neuralgia
, 50.0 mg, 25.0 mg, 75.0 mg, 100.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 225.0 mg, 20.0 mg/mL, 165.0 mg, 82.5 mg, 330.0 mg
, Oral, Capsule, Capsule - Oral, Solution - Oral, Solution, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release - Oral, Tablet, extended release
Fibromyalgia
, 50.0 mg, 25.0 mg, 75.0 mg, 100.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 225.0 mg, 20.0 mg/mL, 165.0 mg, 82.5 mg, 330.0 mg
, Oral, Capsule, Capsule - Oral, Solution - Oral, Solution, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release - Oral, Tablet, extended release
Seizures
, 50.0 mg, 25.0 mg, 75.0 mg, 100.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 225.0 mg, 20.0 mg/mL, 165.0 mg, 82.5 mg, 330.0 mg
, Oral, Capsule, Capsule - Oral, Solution - Oral, Solution, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release - Oral, Tablet, extended release
Peripheral neuropathy
, 50.0 mg, 25.0 mg, 75.0 mg, 100.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 225.0 mg, 20.0 mg/mL, 165.0 mg, 82.5 mg, 330.0 mg
, Oral, Capsule, Capsule - Oral, Solution - Oral, Solution, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release - Oral, Tablet, extended release
Generalized Anxiety Disorder
, 50.0 mg, 25.0 mg, 75.0 mg, 100.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 225.0 mg, 20.0 mg/mL, 165.0 mg, 82.5 mg, 330.0 mg
, Oral, Capsule, Capsule - Oral, Solution - Oral, Solution, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release - Oral, Tablet, extended release
Postherpetic Neuralgia
, 50.0 mg, 25.0 mg, 75.0 mg, 100.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 225.0 mg, 20.0 mg/mL, 165.0 mg, 82.5 mg, 330.0 mg
, Oral, Capsule, Capsule - Oral, Solution - Oral, Solution, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release - Oral, Tablet, extended release
Neuralgia
, 50.0 mg, 25.0 mg, 75.0 mg, 100.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 225.0 mg, 20.0 mg/mL, 165.0 mg, 82.5 mg, 330.0 mg
, Oral, Capsule, Capsule - Oral, Solution - Oral, Solution, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release - Oral, Tablet, extended release
Spinal Cord Injury
, 50.0 mg, 25.0 mg, 75.0 mg, 100.0 mg, 150.0 mg, 200.0 mg, 300.0 mg, 225.0 mg, 20.0 mg/mL, 165.0 mg, 82.5 mg, 330.0 mg
, Oral, Capsule, Capsule - Oral, Solution - Oral, Solution, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release - Oral, Tablet, extended release
Warnings
Pregabalin ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Pregabalin may interact with Pulse Frequency
Common Pregabalin Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Pregabalin may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ethanol
Major
Pregabalin may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Pregabalin is combined with Hydroxyzine.
Lorazepam
Major
The risk or severity of adverse effects can be increased when Pregabalin is combined with Lorazepam.
Mobocertinib
Major
The risk or severity of QTc prolongation can be increased when Pregabalin is combined with Mobocertinib.
Pregabalin Toxicity & Overdose RiskPregabalin has been linked to a range of side effects affecting the central nervous system and cognition, such as dizziness, balance problems, confusion, sleepiness, tremors, difficulty concentrating, tiredness, and euphoria. When taken in high doses (up to 11,500 mg), the most common symptoms of overdose include sleepiness, confusion, restlessness, agitation, depression, and seizures. There is no antidote for pregabalin overdose, so general supportive care should be given. In severe cases, unabsorbed pregabalin may be eliminated with methods such as gastric lavage or emesis, or
Pregabalin Novel Uses: Which Conditions Have a Clinical Trial Featuring Pregabalin?
111 active trials are currently in progress to investigate the potential of Pregabalin for alleviating Peripheral Neuropathy, Postherpetic Neuralgia and Gastrointestinal Absorption Difficulties.Condition
Clinical Trials
Trial Phases
Postherpetic Neuralgia
0 Actively Recruiting
Seizures
2 Actively Recruiting
Phase 3
Vitamin B12 Deficiency
0 Actively Recruiting
No gastrointestinal absorption problems
0 Actively Recruiting
Peripheral neuropathy
1 Actively Recruiting
Not Applicable
Neuropathic Pain
27 Actively Recruiting
Phase 1, Phase 2, Phase 3, Not Applicable, Phase 4
Epilepsies
0 Actively Recruiting
Generalized Anxiety Disorder
32 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 1, Phase 4
Fibromyalgia
0 Actively Recruiting
Neuralgia
0 Actively Recruiting
Diabetic Neuralgia
3 Actively Recruiting
Phase 2, Phase 1
Spinal Cord Injury
44 Actively Recruiting
Not Applicable, Phase 1, Phase 4, Phase 2, Early Phase 1, Phase 3
Pregabalin Reviews: What are patients saying about Pregabalin?
5Patient Review
5/12/2022 I've been dealing with pain from my L1-L3 fracture for 40 years, and this is the first time I've had medication that's really helped. It's allowed me to get off of heroin and finally live a somewhat normal life. The weight gain and clumsiness are unfortunate side effects, but they're worth it to be able to function without constant pain.
5Patient Review
6/1/2022 Without this medication, I would be unable to walk due to the severe neuropathy from diabetes that I have. This has been a lifesaver for me, allowing me to live relatively normally despite my chronic condition.
5Patient Review
5/12/2022 I've been dealing with a lot of pain for 40 years, ever since I fractured my L1-L3 vertebrae. I'm currently taking 300 mg of Pregabalin, 2 15 mg OxyContin, and 1 1mg alprozolam. These have finally helped me manage the pain and live a relatively normal life. Yes, there are some side effects like weight gain and clumsiness, but they're nothing compared to the alternative of living in constant pain.
5Patient Review
5/19/2022 After my stroke, I was left with intense neuropathic pain. This medication has been a godsend in terms of relief, though I find that the effect wears off after a while. Still, it's better than nothing.
5Patient Review
6/1/2022 This medication has been integral to me being able to walk, due to the severe neuropathy I experience from diabetes and multiple foot surgeries.
5Patient Review
5/19/2022 After my stroke, I was in a lot of pain from neuropathy. The previous medication I was on stopped being effective, so I switched to Lyrica. It's been really helpful in managing the pain and has allowed me to get some relief.
4.3Patient Review
5/15/2022 My foot and toes were in a lot of pain before I started this treatment, but I immediately felt relief. Recently, though, the pain has been coming back, so I've had to up my dosage. That's why I'm on this page, doing research to see how much more I can take.
4.3Patient Review
6/23/2022 I've been using this medication for about a week now, and I've found that it offers me pain relief for around four to five hours. The first two of those hours are the strongest in terms of pain reduction, but even the last few hours offer some significant benefits. Additionally, this drug has helped to reduce my anxiety and cravings for cigarettes. So far, no negative side effects to report – though I am planning on discussing an increase in dosage with my doctor given that I still feel sharp pains in my arm from time to time.
4.3Patient Review
5/15/2022 I was in a lot of pain in my left foot and toes. This treatment really helped me, but I've had to up the dosage lately. I'm looking for more information on how much I can take.
4.3Patient Review
6/23/2022 This medication provides me with approximately four to five hours of pain relief, which is definitely welcome. I haven't experienced any negative side effects yet, but I'm going to ask my doctor about increasing the dosage because I can still feel some sharp pains in my arm.
4Patient Review
7/18/2022 I take 75mg at night to help ease nerve pain in my leg from a spinal stenosis. It provides around 6 hours of relief which enables me to sleep. I'm really happy with this product and how it's helped me manage my pain.
4Patient Review
7/18/2022 This medication helps me a lot with the pain I experience from my spinal stenosis. It eases the nerve pain in my leg and allows me to sleep for around six hours.
3.7Patient Review
6/9/2022 I've been using this treatment for years to help with my back problems and neuropathy. It works pretty well, all things considered.
3.7Patient Review
6/9/2022 I've been using this treatment for years to help with my back pain and neuropathy. It works well, but isn't a cure-all.
2.7Patient Review
6/22/2022 I was dealing with a lot of pain in my back and legs due to a bulging disc. Unfortunately, this product didn't do anything to help relieve that pain.
2.7Patient Review
6/22/2022 I didn't find this product effective at all in treating my muscle spasms caused by a bulging disc.
2.3Patient Review
5/17/2022 The first dose was great, but I didn't feel like it worked as well after that. I kept taking it, hoping it would help, but alas, I saw no difference.
2.3Patient Review
5/17/2022 The first dose was great, but I didn't see any difference after that. Started taking ALA afterwards in the hopes that it would help.
2Patient Review
4/10/2022 I found that this medication really impacted my memory and made it hard to concentrate. My appetite also increased quite a bit while I was taking it.
2Patient Review
4/10/2022 I found that this medication really decreased my ability to concentrate and remember things. My appetite also increased quite a bit while I was taking it.
1.3Patient Review
8/17/2022 I was advised to take one pill, then two if one did not work and then max at three. One did nothing, two did not reduce the pain but I felt like I had a hangover the next day along with a migraine headache. I tried three = good for pain but horrible hangover and disorientation the next day and one half.
1.3Patient Review
8/17/2022 I followed the instructions and took one pill, then two when that didn't work. The pain wasn't any better, but I felt awful the next day. Disoriented and with a splitting headache on top of the original pain. Three pills did help with the pain, but then I felt like I was losing my mind from the hangover. Overall, this was a terrible option for me.
1Patient Review
7/19/2022 This pill is extremely dangerous. I was walking into walls and having all sorts of other problems when I took it. When it was offered to my elderly mother, I said no way. The weight gain from this pill is so bad that it should be banned worldwide. If a little child got this, I don't know if they would survive. It's an evil pill that causes terrible mental problems like depression and suicidal thoughts.
1Patient Review
8/18/2022 I was given this medication after two failed spinal operations. I have been experiencing a lot of nerve pain, so they increased my dose to 225mg per day. I take one in the morning and two at night, but my pain is still here.
1Patient Review
7/19/2022 This pill is dangerous. I was walking into walls and just everything. When it was offered to my elderly mum, there was no way. The weight gain from this pill is so bad. Lyrics should be banned worldwide. If a little child got this, I don't know if they would survive. Evil pill.. get rid of it for good.
1Patient Review
8/18/2022 I was given this medication after two failed spinal surgeries. I have been dealing with a lot of nerve pain, and they increased my dose to 225mg per day. I take one pill in the morning and two at night, but I'm still in a lot of pain.
Patient Q&A Section about pregabalin
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is pregabalin for mental health?
"Pregabalin is a drug that is related to the brain chemical GABA, which has a calming effect. Pregabalin reduces the release of brain chemicals that have a stimulating effect and can help with anxiety."
Answered by AI
What does pregabalin do to the nerves?
"Pregabalin is a medication used to treat seizures. It works by reducing the number of pain signals sent out by damaged nerves in the body."
Answered by AI
What is pregabalin used for?
"Pregabalin can help relieve certain types of nerve pain. It is typically used to treat conditions such as epilepsy, anxiety, and diabetic nerve pain. However, it can also be effective in treating nerve pain caused by other conditions such as shingles or an injury."
Answered by AI