Dexilant Solutab

Heartburn, Erosive Esophagitis, Esophagitis

Treatment

6 FDA approvals

4 Active Studies for Dexilant Solutab

Treatment for

Heartburn

What is Dexilant Solutab

Dexlansoprazole

The Generic name of this drug

Treatment Summary

Dexlansoprazole is a type of proton pump inhibitor (PPI) used to treat symptoms of gastroesophageal reflux disease (GERD) and erosion of the esophagus. Unlike other PPIs, dexlansoprazole is released in two phases at different pH values and times, providing two peak concentrations in the blood within 1-2 hours and 4-5 hours after dosing. This helps prevent breakthrough symptoms and the need for meal-associated dosing. Dexlansoprazole works by inhibiting the (H+, K+)-ATPase enzyme, which is involved in

Kapidex

is the brand name

image of different drug pills on a surface

Dexilant Solutab Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Kapidex

Dexlansoprazole

2009

Approved as Treatment by the FDA

Dexlansoprazole, also called Kapidex, is approved by the FDA for 6 uses including Symptomatic Non-erosive Gastroesophageal Reflux Disease and healed erosive esophagitis .

Symptomatic Non-erosive Gastroesophageal Reflux Disease

healed erosive esophagitis

Helps manage healed erosive esophagitis

Heartburn

Helps manage Heartburn

Heartburn

Helps manage Heartburn

Esophagitis

Helps manage healed erosive esophagitis

Erosive Esophagitis

Effectiveness

How Dexilant Solutab Affects Patients

Dexlansoprazole is a type of drug that helps reduce acid production in the stomach. It works by blocking the enzyme that produces acid in the stomach (H+, K+)-ATPase, which can reduce symptoms of heartburn and other acid-related issues.

How Dexilant Solutab works in the body

Dexlansoprazole works by inhibiting the enzyme that helps control the amount of acid produced in the stomach. This enzyme, known as H/K ATPase, is activated when it comes into contact with an acidic environment. Dexlansoprazole binds to the SH groups of the enzyme and prevents it from transporting hydrogen ions into the stomach, which reduces the amount of acid produced. Dexlansoprazole also has a special delivery system that releases 25% of the drug dose in the upper part of the small intestine and 75% in the lower part. This helps reduce both basal and stimulated gastric acid production.

When to interrupt dosage

The dosage of Dexilant Solutab is subject to the revealed condition, such as healed erosive esophagitis, symptomatic non-erosive gastroesphageal reflux disease and Heartburn. The degree of dosage is contingent upon the administration technique (e.g. Capsule, delayed release or Tablet, orally disintegrating, delayed release) outlined in the table beneath.

Condition

Dosage

Administration

Heartburn

, 30.0 mg, 60.0 mg

Oral, , Capsule, delayed release, Capsule, delayed release - Oral, Capsule, delayed release - Nasogastric; Oral, Nasogastric; Oral, Tablet, orally disintegrating, delayed release - Oral, Tablet, orally disintegrating, delayed release

Erosive Esophagitis

, 30.0 mg, 60.0 mg

Esophagitis

, 30.0 mg, 60.0 mg

Warnings

There are 20 known major drug interactions with Dexilant Solutab.

Common Dexilant Solutab Drug Interactions

Drug Name

Risk Level

Description

Acenocoumarol

Major

The metabolism of Acenocoumarol can be decreased when combined with Dexlansoprazole.

Atazanavir

Major

Dexlansoprazole can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy.

Axitinib

Major

The metabolism of Axitinib can be decreased when combined with Dexlansoprazole.

Cyclophosphamide

Major

The metabolism of Cyclophosphamide can be decreased when combined with Dexlansoprazole.

Infigratinib

Major

The serum concentration of Infigratinib can be decreased when it is combined with Dexlansoprazole.

Dexilant Solutab Toxicity & Overdose Risk

The highest dose of DEXILANT that is not toxic to mice, rats, and dogs is greater than 5,000 mg/kg. Common side effects include diarrhea, stomach pain, nausea, upper respiratory infection, vomiting, and gas. There have not been reports of serious overdose, but serious increases in blood pressure have been associated with taking twice daily doses of DEXILANT 60 mg. Animal studies have shown that long-term use of DEXILANT could cause cancer in rats. It is not expected to affect fertility or reproductive systems.

image of a doctor in a lab doing drug, clinical research

Dexilant Solutab Novel Uses: Which Conditions Have a Clinical Trial Featuring Dexilant Solutab?

Currently, seven studies are being conducted to assess the potential of Dexilant Solutab in treating Erosive Esophagitis, healed Erosive Esophagitis and symptomatic non-Erosive Gastroesophageal Reflux Disease.

Condition

Clinical Trials

Trial Phases

Heartburn

2 Actively Recruiting

Phase 3, Not Applicable

Erosive Esophagitis

2 Actively Recruiting

Phase 2, Phase 3

Esophagitis

0 Actively Recruiting

Dexilant Solutab Reviews: What are patients saying about Dexilant Solutab?

Patient Review

3/21/2019

Dexilant Solutab for Condition in which Stomach Acid is Pushed Into the Esophagus

I took this medication for years, but then started to experience bad stomach pains and heart palpitations. I stopped taking it about a year ago and have been doing fine since. I sleep with my bed raised up and drink more water, and am careful of the foods I eat.

Patient Review

4/24/2019

Dexilant Solutab for Condition in which Stomach Acid is Pushed Into the Esophagus

I was taking Tums nightly 4-5 times per week, and within three weeks of starting this medication, I haven't had a single instance of acid reflux!

Patient Review

10/23/2018

Dexilant Solutab for Medication Treatment for Healing Erosive Esophagitis

This treatment has been a godsend for my Crohn's disease.

Patient Review

11/3/2019

Dexilant Solutab for Condition in which Stomach Acid is Pushed Into the Esophagus

This medicine is awesome! Even though it's expensive, it works! I haven't experienced all of the side effects mentioned except for being very hungry at night. I'd rather experience that than the other symptoms I had before taking it. I had a really bad, chronic cough for months and nothing worked.

Patient Review

3/21/2019

Dexilant Solutab for Condition in which Stomach Acid is Pushed Into the Esophagus

I took this medication for years, but then started having bad stomach pains and heart palpitations. I stopped taking it and have been off of it for about one year now. Sleep with my bed raised up and drink more water and I am more careful of the foods I eat--which has made all the difference.

Patient Review

10/23/2018

Dexilant Solutab for Medication Treatment for Healing Erosive Esophagitis

This medication has been an absolute lifesaver. I have Crohn's disease and it's been a constant battle to find something that helps me manage my symptoms. This treatment has finally given me some relief and I couldn't be more grateful.

Patient Review

4/24/2019

Dexilant Solutab for Condition in which Stomach Acid is Pushed Into the Esophagus

I was taking Tums 4-5 nights per week at bedtime, and this medication has completely stopped that. I haven't had any issues with acid reflux since starting it a few weeks ago.

Patient Review

11/3/2019

Dexilant Solutab for Condition in which Stomach Acid is Pushed Into the Esophagus

Though it is expensive, this medicine definitely works and is worth the price. I experienced an increase in appetite at night, but that's a minor side effect compared to the benefits. This treatment finally helped me after months of chronic coughing with no relief from other medicines.

4.3

Patient Review

11/29/2019

Dexilant Solutab for Condition in which Stomach Acid is Pushed Into the Esophagus

I've been taking dexilant for eight months and have put on 22 pounds. I think this is because the medication slows down digestion by turning off stomach acid. It's better than nothing, but the weight gain has been really tough to deal with.

4.3

Patient Review

11/29/2019

Dexilant Solutab for Condition in which Stomach Acid is Pushed Into the Esophagus

I've been taking dexilant for eight months now. I have noticed that I experience dizziness or lightheadedness as a side effect, but the medication is better than nothing. In the past eight months, I have gained 22 pounds. My theory is that the dexilant is turning off too much stomach acid and causing food to sit inside longer and digest more slowly. This weight gain has caused me to buy new clothes and feel ashamed of my appearance in public.

3.7

Patient Review

7/18/2019

Dexilant Solutab for Condition in which Stomach Acid is Pushed Into the Esophagus

This medication was great for the acid, but after taking it for a few months I started having severe pain under my right ribs. My gallbladder was normal on the ultrasound, so I stopped taking the Dexilant and my symptoms went away immediately.

3.7

Patient Review

10/27/2020

Dexilant Solutab for Condition in which Stomach Acid is Pushed Into the Esophagus

Initial results were promising and I only had to take the medication once a day instead of the twice daily dosage of other PPIs. However, I developed such severe diarrhea that I now have hemorrhoids. The side effects are not worth it, so I stopped taking this drug.

3.7

Patient Review

7/18/2019

Dexilant Solutab for Condition in which Stomach Acid is Pushed Into the Esophagus

This medication was great for the acid reflux I was experiencing. However, after taking it for a few months, I started having severe pain in my upper abdomen. I thought it might be my gallbladder, but an ultrasound showed that everything was normal. Once I stopped taking the Dexilant, my symptoms went away almost immediately. Now, I only take it when I'm feeling really bad and try to use it as sparingly as possible.

3.7

Patient Review

10/27/2020

Dexilant Solutab for Condition in which Stomach Acid is Pushed Into the Esophagus

This treatment worked well for my GERD, and I only needed to take it once a day. However, the diarrhea side effect was so bad that I developed hemorrhoids. So I'm no longer taking this medication - the side effects are not worth the pain.

3.3

Patient Review

8/14/2019

Dexilant Solutab for Condition in which Stomach Acid is Pushed Into the Esophagus

I'm an 81-year-old male who's dealt with acid reflux for a long time. Recently, my GI doctor prescribed Dexilant 60mg. I took it for 10 days but then developed nervousness, chest tightness, dizziness, confusion and extreme hunger. So, I went back to Nexium 40mg.

3.3

Patient Review

11/4/2022

Dexilant Solutab for Inflammation of the Esophagus with Erosion

I was prescribed 60mg Dexilant twice a day for 14 days and then 1 a day for 14 days.Around day 7 I noticed an unusual unsettling feeling which got progressively worse. By around day 16 I was feeling quite anxious and irritable. I have never suffered from anxiety in my 70 years.I stopped taking the medication to see if the symptoms would disappear and am waiting to see how long that takes.

3.3

Patient Review

8/14/2019

Dexilant Solutab for Condition in which Stomach Acid is Pushed Into the Esophagus

I'm an 81-year-old man who has dealt with acid reflux for quite some time. Recently, my GI doctor prescribed Dexilant 60mg. I took it for 10 days but then developed a lot of unpleasant side effects, including nervousness, chest tightness, dizziness, confusion, and extreme hunger. So I went back to taking Nexium 40mg.

3.3

Patient Review

11/4/2022

Dexilant Solutab for Inflammation of the Esophagus with Erosion

I was prescribed 60mg Dexilant twice a day for 14 days and then 1 a day for 14 days.Around day 7 I noticed an unusual unsettling feeling which got progressively worse. By around day 16 I was feeling quite anxious and irritable. I have never suffered from anxiety in my 70 years.I have stopped taking the medication and will await to see how long for the symptoms to disappear.

Patient Review

6/11/2019

Dexilant Solutab for Condition in which Stomach Acid is Pushed Into the Esophagus

I was prescribed Dexilant 60MG once a day to eliminate acid entering the esophagus. It worked fine for the first 3 1/2 months but then I started getting symptoms of severe headache, confusion, brain fog and stomach pains. My PCP made the assumption it was stress and anxiety when in fact it was the dexilant. I stopped taking it and now have no symptoms!

Patient Review

8/7/2022

Dexilant Solutab for Inflammation of the Esophagus with Erosion

I initially noticed an improvement in my condition when I started taking dexilant. However, after a week I developed some concerning side effects. These included pain around my rib cage, extreme hunger, anxiety and irritability. Thankfully, these effects have diminished since I stopped taking the medication 3 days ago.

Patient Review

6/11/2019

Dexilant Solutab for Condition in which Stomach Acid is Pushed Into the Esophagus

I was prescribed Dexilant 60MG to eliminate acid entering the esophagus. It worked for the first 3 1/2 months but then I started getting symptoms of severe headache, confusion, brain fog and stomach pains. My PCP made the assumption it was stress and anxiety when in fact it was the dexilant. I stopped taking it and now have no symptoms!

Patient Review

8/7/2022

Dexilant Solutab for Inflammation of the Esophagus with Erosion

I initially noticed a reduction in the burning sensation I felt in my chest. However, after only a week of taking dexilant, I started to experience pain around my left ribs and an intense feeling of hunger. Additionally, I found myself becoming more anxious and irritable--which are definitely not qualities that describe me normally. Thankfully, since discontinuing use of the medication three days ago, these side effects have begun to subside.

2.3

Patient Review

9/5/2019

Dexilant Solutab for Excessive Production of Stomach Acid

I was on Dexilant for about two months. I had chronic diarrhea, lost a lot of weight, and felt constantly full. This led to me being hospitalized for dehydration and low blood sugar. Once I stopped taking the medication, I immediately started feeling better. If you experience similar side effects, be sure to talk to your doctor right away.

2.3

Patient Review

9/5/2019

Dexilant Solutab for Excessive Production of Stomach Acid

I experienced some serious gastrointestinal issues while taking this medication. I lost a lot of weight and ended up in the ER twice as a result. If you're feeling full all the time, definitely speak to your doctor about it.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about dexilant solutab

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is DEXILANT being discontinued?

"is the last update for the Dexilant SoluTab brand name. If the FDA has approved generic versions of this product, there may be equivalent generic versions available."

Answered by AI

What is DEXILANT SoluTab?

"Dexilant SoluTab is a drug indicated for the treatment of heartburn associated with non-erosive gastroesophageal reflux disease, and for the maintenance of healed erosive esophagitis and relief of heartburn in adults 18 years and older."

Answered by AI

What is the best time of day to take DEXILANT?

"This medication is meant to be taken orally, as directed by a doctor. In most cases, it is taken once a day, with or without food. If your symptoms tend to occur after you eat, your doctor may tell you to take the medication before the same meal each day, in order to see the best results."

Answered by AI

What is DEXILANT used for?

"This medication is used to treat erosive esophagitis, which is a condition where the acid in the stomach washes back up into the esophagus, causing heartburn."

Answered by AI