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Cannabis for Pain Relief (CanSex Trial)

Phase 1
Recruiting
Led By Ziva Cooper, PhD
Research Sponsored by University of California, Los Angeles
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
FEMALES: Must be regularly cycling
Male or non-pregnant female aged 21-55 years
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 5 hours
Awards & highlights

CanSex Trial Summary

This trial will study the effects of marijuana on pain relief and potential abuse in men and women.

Who is the study for?
This trial is for men and women aged 21-55 who use cannabis weekly but aren't seeking treatment for it. Women must have regular cycles and use non-hormonal birth control. Participants should be healthy, with a BMI of 18.5 - 34kg/m2, and able to do all study tasks.Check my eligibility
What is being tested?
The CanSex study is testing the effects of actual cannabis versus placebo on pain relief and potential abuse in both men and women to understand if there are sex differences in these responses.See study design
What are the potential side effects?
While specific side effects are not listed, participants will be monitored for any adverse reactions due to smoking cannabis which could include changes in mood, sensory perception, alertness, or coordination.

CanSex Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I have regular menstrual cycles.
Select...
I am between 21 and 55 years old and not pregnant.
Select...
I am using a non-hormonal method of birth control.

CanSex Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~5 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Analgesia as measured using the Cold Pressor Test
Pharmacokinetics of THC and metabolites
Subject-rated drug effects
Secondary outcome measures
Drug reinforcement using the cannabis self-administration task

CanSex Trial Design

3Treatment groups
Experimental Treatment
Placebo Group
Group I: Low strength cannabisExperimental Treatment1 Intervention
Smoked Cannabis (~4% THC)
Group II: Higher strength cannabisExperimental Treatment1 Intervention
Smoked Cannabis (~10% THC)
Group III: PlaceboPlacebo Group1 Intervention
Smoked Cannabis (~0% THC)

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

University of California, Los AngelesLead Sponsor
1,533 Previous Clinical Trials
10,265,422 Total Patients Enrolled
19 Trials studying Substance Abuse
5,873 Patients Enrolled for Substance Abuse
National Institute on Drug Abuse (NIDA)NIH
2,470 Previous Clinical Trials
2,619,479 Total Patients Enrolled
152 Trials studying Substance Abuse
706,982 Patients Enrolled for Substance Abuse
Ziva Cooper, PhDPrincipal InvestigatorUniversity of California, Los Angeles
4 Previous Clinical Trials
237 Total Patients Enrolled
3 Trials studying Substance Abuse
170 Patients Enrolled for Substance Abuse

Media Library

Active Cannabis Clinical Trial Eligibility Overview. Trial Name: NCT04385082 — Phase 1
Substance Abuse Research Study Groups: Placebo, Low strength cannabis, Higher strength cannabis
Substance Abuse Clinical Trial 2023: Active Cannabis Highlights & Side Effects. Trial Name: NCT04385082 — Phase 1
Active Cannabis 2023 Treatment Timeline for Medical Study. Trial Name: NCT04385082 — Phase 1
Substance Abuse Patient Testimony for trial: Trial Name: NCT04385082 — Phase 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Has there been any precedent for experimentation with Active Cannabis?

"At present, 31 trials exploring the potential of Active Cannabis are underway with 3 in their final Phase. The majority are based out of Hartford, Connecticut but span across 46 sites globally."

Answered by AI

Am I eligible to take part in the experiment?

"This clinical trial is recruiting 160 individuals between the ages of 21 and 55 who suffer from chronic pain. In addition to this, prospective participants must meet a few other criteria: females in the trial must be cycling regularly; male or non-pregnant female aged between 21-55 years old; no prior treatment for cannabis use; light users with no reported negative side effects while smoking cannabis; BMI ranging 18.5 - 34kg/m2.; and lastly, all women are required to practice an effective form of birth control that does not involve hormones."

Answered by AI

Is this endeavor the inaugural attempt of its kind?

"Accumulated research on Active Cannabis has been conducted in a total of 32 cities, across 5 countries. This research began with the Jazz Pharmaceutical-sponsored study that involved 200 patients and completed its Phase 2 & 3 drug approval stage in 2015. Since then, an additional 60 trials have been performed to further examine this medication's efficacy."

Answered by AI

What is the total enrollment for this research endeavor?

"Affirmative. Clinicaltrials.gov lists this clinical trial as being open for recruitment since its initial posting on June 30th 2021, with the last update occurring October 9th 2022. The study is currently searching for 160 participants from one medical site."

Answered by AI

To what extent can active cannabis consumption be detrimental to health?

"Active Cannabis received a rating of 1, as this is an early-stage trial and the existing evidence regarding safety and efficacy is still limited."

Answered by AI

Does this experiment have any age restrictions, specifically for individuals younger than 55?

"On the condition that applicants are aged 21 to 55, this trial will accept their inclusion. In addition, 162 studies have been conducted for people under 18 and 555 studies focus on patients over 65 years old."

Answered by AI

Are researchers currently accepting new participants for this clinical trial?

"Indeed, clinicaltrials.gov displays that this trial is looking for participants; the initial posting was on June 30th 2021 and the most recent update occurred on October 9th 2022."

Answered by AI

Who else is applying?

What state do they live in?
Nevada
California
How old are they?
18 - 65
What site did they apply to?
University of California, Los Angeles
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
0

Why did patients apply to this trial?

It's local to me, I meet the qualifications, and I'm interested in part time income.
PatientReceived 1 prior treatment
I've tried pain killers, even muscle relaxers. While using cannabis has been my most long-term usage of pain reduction, I'd hope this clinical trial helps me see the big picture.
PatientReceived 2+ prior treatments

What questions have other patients asked about this trial?

How do I reapply if I'm not selected?
PatientReceived 2+ prior treatments

How responsive is this trial?

Typically responds via
Email
~44 spots leftby Jun 2025