Phoslyra
Hyperphosphataemia, Communicable Diseases, Dialysis therapy + 4 more
Treatment
3 FDA approvals
3 Active Studies for Phoslyra
Treatment for
Hyperphosphataemia
What is Phoslyra
Calcium acetate
The Generic name of this drug
Treatment Summary
Calcium acetate is a compound made from calcium and acetic acid. It's also known as the acetate of lime. The anhydrous form of this compound is very absorbent, so it usually comes in the form of the monohydrate.
ProcalAmine
is the brand name
Phoslyra Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
ProcalAmine
Calcium acetate
1982
77
Approved as Treatment by the FDA
Calcium acetate, otherwise known as ProcalAmine, is approved by the FDA for 3 uses which include Kidney Failure, Chronic and End-stage Renal Failure (ESRF) .
Kidney Failure, Chronic
Helps manage End-stage Renal Failure (ESRF)
End-stage Renal Failure (ESRF)
Helps manage End-stage Renal Failure (ESRF)
Hyperphosphataemia
Helps manage Hyperphosphataemia
Effectiveness
How Phoslyra Affects Patients
Patients with serious kidney problems may build up phosphate in their bodies, which can lead to high blood levels of parathyroid hormone and calcium deposits in the body. To help control this, dietary phosphate needs to be reduced, as well as using a medication called calcium acetate to bind to any dietary phosphate and remove it from the body. This helps keep the level of phosphorus in the blood below 6.0 mg/dl. Calcium acetate dissolves easily and helps bind phosphate in the small intestine before it is absorbed.
How Phoslyra works in the body
Calcium acetate and other calcium salts help manage phosphate levels in the body. They do this by binding to the phosphate found in food, preventing it from being absorbed into your bloodstream.
When to interrupt dosage
The prescribed dosage of Phoslyra is contingent upon the diagnosed condition, including Kidney, Hyperphosphataemia and Kidney Failure, Chronic. The amount of dosage is dependent on the mode of administration (e.g. Intravenous or Topical) specified in the table below.
Condition
Dosage
Administration
Hyperphosphataemia
667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL
, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Solution, Solution - Oral, Powder, for solution - Topical, Topical, Powder, for solution, Solution - Topical, Injection - Intravenous, Injection, Intravenous, Injection, solution, concentrate - Intravenous, Injection, solution, concentrate, Liquid, Solution - Intravenous, Liquid - Intravenous, Tablet, coated, Tablet, coated - Oral
Kidney
667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL
, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Solution, Solution - Oral, Powder, for solution - Topical, Topical, Powder, for solution, Solution - Topical, Injection - Intravenous, Injection, Intravenous, Injection, solution, concentrate - Intravenous, Injection, solution, concentrate, Liquid, Solution - Intravenous, Liquid - Intravenous, Tablet, coated, Tablet, coated - Oral
high phosphate levels
667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL
, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Solution, Solution - Oral, Powder, for solution, Powder, for solution - Topical, Topical, Solution - Topical, Injection - Intravenous, Injection, Intravenous, Injection, solution, concentrate - Intravenous, Injection, solution, concentrate, Liquid, Solution - Intravenous, Liquid - Intravenous, Tablet, coated, Tablet, coated - Oral
Astringent
667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL
, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Solution, Solution - Oral, Powder, for solution, Powder, for solution - Topical, Topical, Solution - Topical, Injection - Intravenous, Injection, Intravenous, Injection, solution, concentrate - Intravenous, Injection, solution, concentrate, Liquid, Solution - Intravenous, Liquid - Intravenous, Tablet, coated, Tablet, coated - Oral
Communicable Diseases
667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL
, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Solution, Solution - Oral, Powder, for solution - Topical, Topical, Powder, for solution, Solution - Topical, Injection - Intravenous, Injection, Intravenous, Injection, solution, concentrate - Intravenous, Injection, solution, concentrate, Liquid, Solution - Intravenous, Liquid - Intravenous, Tablet, coated, Tablet, coated - Oral
Dialysis therapy
667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL
, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Solution, Solution - Oral, Powder, for solution - Topical, Topical, Powder, for solution, Solution - Topical, Injection - Intravenous, Injection, Intravenous, Injection, solution, concentrate - Intravenous, Injection, solution, concentrate, Liquid, Solution - Intravenous, Liquid - Intravenous, Tablet, coated, Tablet, coated - Oral
Kidney Failure, Chronic
667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL
, Oral, Tablet - Oral, Tablet, Capsule - Oral, Capsule, Solution, Solution - Oral, Powder, for solution - Topical, Topical, Powder, for solution, Solution - Topical, Injection - Intravenous, Injection, Intravenous, Injection, solution, concentrate - Intravenous, Injection, solution, concentrate, Liquid, Solution - Intravenous, Liquid - Intravenous, Tablet, coated, Tablet, coated - Oral
Warnings
Phoslyra Contraindications
Condition
Risk Level
Notes
Hypercalcemia
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Phoslyra.
Common Phoslyra Drug Interactions
Drug Name
Risk Level
Description
Technetium Tc-99m oxidronate
Major
Calcium acetate may decrease effectiveness of Technetium Tc-99m oxidronate as a diagnostic agent.
Dobutamine
Minor
The therapeutic efficacy of Dobutamine can be decreased when used in combination with Calcium acetate.
3-Aza-2,3-Dihydrogeranyl Diphosphate
Moderate
Calcium acetate can cause a decrease in the absorption of 3-Aza-2,3-Dihydrogeranyl Diphosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Acebutolol
Moderate
The therapeutic efficacy of Acebutolol can be decreased when used in combination with Calcium acetate.
Acetyldigitoxin
Moderate
Calcium acetate may increase the arrhythmogenic and cardiotoxic activities of Acetyldigitoxin.
Phoslyra Toxicity & Overdose Risk
The lowest toxic dose of oral rat is 4280mg/kg. Symptoms of overdose may include constipation, lack of appetite, nausea, vomiting, confusion, loss of consciousness, and difficulty speaking.
Phoslyra Novel Uses: Which Conditions Have a Clinical Trial Featuring Phoslyra?
There are currently 5 active studies evaluating the potential of Phoslyra to reduce Kidney-related high phosphate levels and Hyperphosphataemia.
Condition
Clinical Trials
Trial Phases
high phosphate levels
0 Actively Recruiting
Kidney Failure, Chronic
0 Actively Recruiting
Communicable Diseases
0 Actively Recruiting
Hyperphosphataemia
0 Actively Recruiting
Dialysis therapy
3 Actively Recruiting
Not Applicable, Phase 3, Phase 4
Astringent
0 Actively Recruiting
Kidney
0 Actively Recruiting
Patient Q&A Section about phoslyra
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What is Phoslyra used for?
"Phoslyra is a medication indicated for reducing the serum phosphorus levels in patients with end stage renal disease. It works by binding to phosphate in the gastrointestinal tract, thus preventing its absorption."
Answered by AI
What is calcium acetate used for?
"Calcium acetate is a medication used to treat hyperphosphatemia (too much phosphate in the blood) in patients with end stage kidney disease who are on dialysis. Calcium acetate works by binding with the phosphate in the food you eat, so that it is eliminated from the body without being absorbed."
Answered by AI
How do you take Phoslyra?
"You should take this medication with each meal, and the dosage will be based on your medical condition and how you respond to treatment. If you're using the liquid form, make sure to use a medication-measuring device or spoon to get the correct dose. Don't use a household spoon, because you might not get the right amount."
Answered by AI
Does calcium acetate come in liquid?
"Take calcium acetate with each meal, as directed by your doctor."
Answered by AI