Esomeprazole Sodium

Zollinger-Ellison Syndrome, Curling Ulcer, Heartburn + 14 more

Treatment

5 FDA approvals

18 Active Studies for Esomeprazole Sodium

What is Esomeprazole Sodium

Esomeprazole

The Generic name of this drug

Treatment Summary

Esomeprazole (Nexium) is a medication used to reduce stomach acid production in people with gastrointestinal disorders. It is used to treat gastroesophageal reflux disease (GERD), peptic ulcer disease, and conditions caused by excessive stomach acid production. Esomeprazole works by blocking the action of an enzyme that helps produce stomach acid. While it is generally well-tolerated, long-term use of this medication may increase the risk of some health issues, such as bacterial infections, reduced absorption of micronutrients, and an increased risk of cardiovascular events. To avoid a rebound effect

Nexium

is the brand name

image of different drug pills on a surface

Esomeprazole Sodium Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Nexium

Esomeprazole

2001

347

Approved as Treatment by the FDA

Esomeprazole, otherwise called Nexium, is approved by the FDA for 5 uses including Heartburn and Heartburn .

Heartburn

Heartburn

Helicobacter Pylori Infection

Used to treat Helicobacter Pylori Infection in combination with Amoxicillin

Gastro-esophageal Reflux Disease (GERD)

Helps manage Gastro-esophageal Reflux Disease (GERD)

Heartburn

Helps manage Gastro-esophageal Reflux Disease (GERD)

Effectiveness

How Esomeprazole Sodium Affects Patients

Esomeprazole helps treat gastroesophageal reflux disease (GERD), heal erosive esophagitis, and prevent duodenal ulcer recurrence. It works by blocking the acid secretion in your stomach, so that less acid enters the stomach's lining. Esomeprazole is similar to other drugs in its class (PPIs) in that it can reduce the activity of an enzyme important for cardiovascular health, which may increase the risk of cardiovascular events. Despite potential long-term side effects, esomeprazole is widely used in North America due to its good safety profile and availability

How Esomeprazole Sodium works in the body

Esomeprazole works by blocking the final step in the production of stomach acid. It does this by attaching to certain proteins on the surface of the stomach cells that produce acid. This prevents the stomach from making acid no matter what the trigger is. This binding is permanent, so it lasts longer than a day and new proteins need to be formed to start producing acid again.

When to interrupt dosage

The proposed dosage of Esomeprazole Sodium is contingent upon the diagnosed ailment, including Curling Ulcer, Hemorrhage and Critical Illness. The degree of dose fluctuates as per the technique of administration (e.g. Tablet, delayed release or Injection, powder, lyophilized, for solution - Intravenous) specified in the table underneath.

Condition

Dosage

Administration

Heartburn

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Hemorrhage

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Hemorrhage

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Stress Ulcers

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Stomach Ulcer

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

antibacterial therapy

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Zollinger-Ellison Syndrome

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Curling Ulcer

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Peptic Ulcer

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

maintenance of healing Erosive esophagitis

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Gastric ulcer

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Peptic Ulcer

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Erosive Esophagitis

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Critical Illness

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Helicobacter Pylori Infection

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

prophylaxis of Stress Ulcers

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Heartburn

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Warnings

Esomeprazole Sodium has one contraindication and should not be administered with any of the conditions detailed in the subsequent table.

Esomeprazole Sodium Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Esomeprazole Sodium.

Common Esomeprazole Sodium Drug Interactions

Drug Name

Risk Level

Description

Acenocoumarol

Major

The metabolism of Acenocoumarol can be decreased when combined with Esomeprazole.

Atazanavir

Major

Esomeprazole can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy.

Axitinib

Major

The metabolism of Axitinib can be decreased when combined with Esomeprazole.

Cyclophosphamide

Major

The metabolism of Cyclophosphamide can be decreased when combined with Esomeprazole.

Infigratinib

Major

The serum concentration of Infigratinib can be decreased when it is combined with Esomeprazole.

Esomeprazole Sodium Toxicity & Overdose Risk

Side effects of taking too much of this drug may include blurry vision, confusion, fatigue, dry mouth, facial warmth, headache, nausea, racing heartbeat, and excessive sweating.

image of a doctor in a lab doing drug, clinical research

Esomeprazole Sodium Novel Uses: Which Conditions Have a Clinical Trial Featuring Esomeprazole Sodium?

There are currently 26 active clinical trials assessing the potential of Esomeprazole Sodium to improve outcomes in patients with previous gastric or duodenal ulcer, Stomach Ulcer and Peptic Ulcer.

Condition

Clinical Trials

Trial Phases

Hemorrhage

0 Actively Recruiting

Curling Ulcer

0 Actively Recruiting

antibacterial therapy

0 Actively Recruiting

Heartburn

2 Actively Recruiting

Phase 3, Not Applicable

Erosive Esophagitis

2 Actively Recruiting

Phase 2, Phase 3

Gastric ulcer

0 Actively Recruiting

Helicobacter Pylori Infection

2 Actively Recruiting

Not Applicable, Phase 4

Stomach Ulcer

0 Actively Recruiting

Zollinger-Ellison Syndrome

0 Actively Recruiting

Stress Ulcers

0 Actively Recruiting

maintenance of healing Erosive esophagitis

0 Actively Recruiting

Peptic Ulcer

0 Actively Recruiting

Critical Illness

0 Actively Recruiting

Hemorrhage

0 Actively Recruiting

Heartburn

12 Actively Recruiting

Phase 3, Phase 2, Not Applicable

Peptic Ulcer

0 Actively Recruiting

prophylaxis of Stress Ulcers

0 Actively Recruiting

Patient Q&A Section about esomeprazole sodium

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is esomeprazole sodium used for?

"Esomeprazole injection is used to treat conditions where there is too much acid in the stomach. It is used for the short-term treatment (up to 10 days) of gastroesophageal reflux disease (GERD) with erosive esophagitis in adults and children 1 month of age and older."

Answered by AI

Is it OK to take esomeprazole every day?

"You may only take esomeprazole for a few weeks or months if it has been prescribed for you, depending on your condition. Sometimes your doctor may advise you to take it for longer, even many years. Your doctor may only suggest taking esomeprazole when you have symptoms, which means you will not have to take it every day."

Answered by AI

Is esomeprazole magnesium the same as Nexium?

"That means you may need to take it with other drugs.

Esomeprazole magnesium is sold as both the brand-name drug Nexium and a generic drug. Generic drugs typically cost less money than their brand-name counterparts. In some instances, generic drugs may not be offered in the same strength or form as the brand-name drug. Esomeprazole magnesium may be used in tandem with other drugs as part of a combination therapy."

Answered by AI

What is esomeprazole 40 mg used for?

"Nonprescription esomeprazole is used to treat frequent heartburn in adults. Esomeprazole is a type of medication called a proton pump inhibitor, which decreases the amount of acid made in the stomach."

Answered by AI

Clinical Trials for Esomeprazole Sodium

Image of University of California, Irvine - UCI Medical Center in Orange, United States.

Sling-Fiber Preservation vs. Conventional POEM for Achalasia

18+
All Sexes
Orange, CA

Peroral endoscopic myotomy (POEM) is an effective, minimally invasive treatment for achalasia, offering excellent rates of symptom relief. However, a significant drawback is the high incidence of gastroesophageal reflux disease (GERD) following the procedure. One proposed technical modification, the selective preservation of the sling fibers during gastric myotomy (SFP-POEM), may reduce this risk without compromising efficacy as compared to a conventional POEM procedure, which includes myotomy of the sling fibers. In this study, adults with achalasia will be randomly assigned to receive one of the two POEM technical approaches. Researchers will monitor whether preserving sling fibers reduces the rates of reflux esophagitis (classified as Los Angeles Grade B or higher) on follow-up endoscopy. Participants will be followed for up to 1 year after the procedure.

Waitlist Available
Has No Placebo

University of California, Irvine - UCI Medical Center

Jason Samarasena, MD, MBA

Image of Del Sol Research Management, LLC in Tucson, United States.

Linaprazan Glurate vs Lansoprazole for Acid Reflux

18 - 80
All Sexes
Tucson, AZ

The goal of this clinical trial is to find out how well linaprazan glurate can heal erosive esophagitis (EE) caused by gastroesophageal reflux disease (GERD), compared to lansoprazole, a commonly used medication. Researchers will also evaluate whether linaprazan glurate: * Reduces heartburn symptoms more effectively than lansoprazole * Is safe and well tolerated, based on physical exams, blood tests, and vital signs (heart rate, blood pressure, temperature, and breathing rate) * Causes any side effects during treatment * Has different effects depending on how much of the drug is in the blood * Works differently depending on participants' genes Participants must be between 18 to 80 years old and have EE due to GERD confirmed by an endoscopy. Participants cannot join if they have an active Helicobacter pylori (HP) infection or were treated for HP in the past 6 weeks or have taken antibiotics or bismuth-containing drugs in the past 6 weeks. The study is a randomized, double-blind, active comparator-controlled trial lasting up to 4 months. Randomized means that participants are assigned by chance (like flipping a coin) to one of the treatment groups and double-blind means neither the participants nor the study team will know which treatment is given. Participants will be placed into one of three groups (about 167 people in each group): * Linaprazan glurate 50 mg twice a day * Linaprazan glurate 50 mg once a day * Lansoprazole 30 mg once a day Everyone will take 2 tablets and 1 capsule by mouth daily for 8 weeks. Some tablets or capsules will be placebos (look like medicine but contain no active drug). Participants will: * Undergo an endoscopy in the beginning and after 4 weeks of treatment * If healing is not observed, another endoscopy may be done at 8 weeks * During the procedure, doctors will use a thin, flexible tube with a camera to look at the esophagus and take small tissue samples (biopsies) * Have blood and urine tests at clinic visits to check overall health * Receive electrocardiograms (ECGs) to monitor heart function * Complete daily questionnaires on an electronic device about symptoms and experiences

Phase 3
Waitlist Available

Del Sol Research Management, LLC (+24 Sites)

Cinclus Pharma Holding AB

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Image of Brigham and Women's Hospital in Boston, United States.

Argon Plasma for Helicobacter Pylori Infection

18+
All Sexes
Boston, MA

The objective of the study is to investigate the efficacy and safety of an argon plasma-based therapy - HEAPE - in treating H. pylori infections during endoscopic procedures. By filling the stomach with sodium chloride solution that is treated with APC (PAL), the Investigators hypothesize a significant reduction in H. pylori. The use of PAL instead of direct application of APC allows for a broader and more homogeneous application throughout the stomach and a faster procedure time, as the fluid bypasses the thermal effects typically associated with higher electrical power settings and focuses on the bactericidal action of PAL. It is a procedure that does not involve thermal ablation of the stomach lining. Thus, side effects should be expected to be as low as possible. Two different PAL generation modalities will be compared in this study: 1. HEAPE direct: This modality is the direct generation of PAL in the stomach. The stomach is filled with sodium chloride solution which is then treated with APC. With HEAPE direct a potential decrease of reactive species is avoided, as the treatment happens directly at the intended location in the H. pylori infected stomach. 2. Pre-HEAPE: This modality features the treatment of sodium chloride with APC outside of the patient in a sterile container. After the APC treatment, the generated PAL is administered into the stomach with a syringe through the working channel of the endoscope. Pre-HEAPE allows an easier handling of the APC probe as the treatment of the sodium chloride solution can be done without an endoscope. To evaluate the immediate effect of this novel treatment approach the metabolic activity of H. pylori will be assessed using a urea breath test (UBT) before and after treatment. A reduction in H. pylori levels can be detected by a reduction in urease activity in the breath test. After the HEAPE procedure, patients are treated with antibiotics (best practice) as they would be under normal circumstances. Four weeks after treatment, another UBT is performed to determine if H. pylori has been eradicated or if additional antibiotic treatment is indicated. This two-arm, randomized, pilot, single-center, prospective clinical study is designed to evaluate the safety, tolerability and proof of concept that PAL has the ability to eradicate or reduce the bacterial load of H. pylori in humans.

Recruiting
Has No Placebo

Brigham and Women's Hospital

Christopher C Thompson, MD

Erbe Elektromedizin GmbH

Image of Cleveland Clinic Center for Abdominal Core Health in Cleveland, United States.

Mesh vs Pledgets for Hernia Repair

18+
All Sexes
Cleveland, OH

The goal of this clinical trial is to compare whether the use of Ovitex mesh provides superior reduction in 2-year recurrence compared to pledgeted suture closure (no mesh) for patients undergoing paraesophageal hernia repair at the Cleveland Clinic. The main questions it aims to answer are: * Determine whether there is a difference in 2-year rates of radiographic recurrence with Ovitex versus pledgeted sutures in paraesophageal hernia repair. * Assess patient quality of life (QOL) after paraesophageal hernia repair with pledgets and mesh. A two-tailed research hypothesis will be used to determine whether there are differences between the two arms

Recruiting
Has No Placebo

Cleveland Clinic Center for Abdominal Core Health

David M Krpata, MD

Have you considered Esomeprazole Sodium clinical trials?

We made a collection of clinical trials featuring Esomeprazole Sodium, we think they might fit your search criteria.
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Have you considered Esomeprazole Sodium clinical trials?

We made a collection of clinical trials featuring Esomeprazole Sodium, we think they might fit your search criteria.
Go to Trials