Levalbuterol Hydrochloride

Bronchial Spasm, prophylaxis of Bronchospasm, Chronic Obstructive Pulmonary Disease

Treatment

3 FDA approvals

20 Active Studies for Levalbuterol Hydrochloride

Treatment for

Bronchial Spasm

What is Levalbuterol Hydrochloride

LevosalbutamolThe Generic name of this drug

Treatment SummaryLevosalbutamol, also known as levalbuterol, is a medication used to treat asthma and COPD. It is an advanced version of salbutamol that works by stimulating the β2 adrenergic receptors. Levosalbutamol is an enantiomerically pure form of salbutamol, meaning it only contains the active ingredient and no other chemicals, making it more effective and safer than the racemic mixture of salbutamol.

Xopenexis the brand name

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Levalbuterol Hydrochloride Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Xopenex

Levosalbutamol

1999

Approved as Treatment by the FDA

Levosalbutamol, commonly known as Xopenex, is approved by the FDA for 3 uses which include Bronchospasm and Bronchial Spasm .

Bronchospasm

Bronchial Spasm

prophylaxis of Bronchospasm

Effectiveness

How Levalbuterol Hydrochloride Affects PatientsThis drug works by making the muscles around the airways in the lungs relax, which allows more air to flow and relieves difficulty breathing.

How Levalbuterol Hydrochloride works in the bodyLevosalbutamol works by activating a receptor on the airway smooth muscle. This stimulates a cascade of reactions that ultimately relax the muscles and reduce the release of substances from mast cells. This helps reduce symptoms of asthma attacks.

When to interrupt dosage

The advocated dosage of Levalbuterol Hydrochloride is contingent upon the diagnosed state, including Chronic Obstructive Pulmonary Disease (COPD), Bronchospasm and prophylaxis of Bronchospasm. The dose fluctuates, per the technique of delivery (e.g. Respiratory (inhalation) or Oral) outlined in the following table.

Condition

Dosage

Administration

Bronchial Spasm

, 0.045 mg, 12.5 mg/mL, 1.25 mg/mL, 0.63 mg/mL, 0.31 mg/mL

Oral, Aerosol, metered - Oral, Aerosol, metered, , Respiratory (inhalation), Solution, concentrate, Solution, concentrate - Respiratory (inhalation), Solution, Solution - Respiratory (inhalation)

prophylaxis of Bronchospasm

, 0.045 mg, 12.5 mg/mL, 1.25 mg/mL, 0.63 mg/mL, 0.31 mg/mL

Oral, Aerosol, metered - Oral, Aerosol, metered, , Respiratory (inhalation), Solution, concentrate, Solution, concentrate - Respiratory (inhalation), Solution, Solution - Respiratory (inhalation)

Chronic Obstructive Pulmonary Disease

, 0.045 mg, 12.5 mg/mL, 1.25 mg/mL, 0.63 mg/mL, 0.31 mg/mL

Oral, Aerosol, metered - Oral, Aerosol, metered, , Respiratory (inhalation), Solution, concentrate, Solution, concentrate - Respiratory (inhalation), Solution, Solution - Respiratory (inhalation)

Warnings

Levalbuterol Hydrochloride Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Levalbuterol Hydrochloride.

Common Levalbuterol Hydrochloride Drug Interactions

Drug Name

Risk Level

Description

2,5-Dimethoxy-4-ethylthioamphetamine

Minor

The risk or severity of hypertension can be increased when Levosalbutamol is combined with 2,5-Dimethoxy-4-ethylthioamphetamine.

5-methoxy-N,N-dimethyltryptamine

Minor

The risk or severity of hypertension can be increased when Levosalbutamol is combined with 5-methoxy-N,N-dimethyltryptamine.

Acemetacin

Minor

The risk or severity of hypertension can be increased when Levosalbutamol is combined with Acemetacin.

Albutrepenonacog alfa

Minor

Levosalbutamol may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.

Alclofenac

Minor

The risk or severity of hypertension can be increased when Levosalbutamol is combined with Alclofenac.

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Levalbuterol Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Levalbuterol Hydrochloride?

98 active clinical trials are currently being conducted to evaluate the potential of Levalbuterol Hydrochloride to provide prophylaxis for Bronchospasm, Chronic Obstructive Pulmonary Disease (COPD) and Bronchospasm.

Condition

Clinical Trials

Trial Phases

prophylaxis of Bronchospasm

0 Actively Recruiting

Chronic Obstructive Pulmonary Disease

77 Actively Recruiting

Phase 3, Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 4

Bronchial Spasm

0 Actively Recruiting

Levalbuterol Hydrochloride Reviews: What are patients saying about Levalbuterol Hydrochloride?

4Patient Review

12/28/2012

Levalbuterol Hydrochloride for Asthma Attack

I took this medication for acute bronchitis and found that it really helped me to breathe. The downside is that I experienced some mild side effects like headaches, tremors, and indigestion issues.

4Patient Review

10/23/2013

Levalbuterol Hydrochloride for Bronchospasm

This treatment can cause dry mouth and trembling, but it's effective.

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Patient Q&A Section about levalbuterol hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is levalbuterol better than albuterol?

"There is no difference in effectiveness or side effects between albuterol and levalbuterol in children with moderate asthma exacerbations."

Answered by AI

What is levalbuterol hcl used for?

"Levalbuterol is used to prevent or treat bronchospasm by relaxing the muscles in the airways. This medicine is also used to treat other lung diseases. Levalbuterol belongs to the family of medicines known as adrenergic bronchodilators."

Answered by AI

Is levalbuterol the same as albuterol?

"Albuterol and levalbuterol are both drugs that are used to treat asthma. They are similar in that they are both bronchodilators. They are not exactly the same, though, as levalbuterol is composed of just R-albuterol, while albuterol is a racemic mixture of both R-albuterol and S-albuterol."

Answered by AI

How quickly does levalbuterol work?

"Steroids are used in asthma to lower inflammation in lungs and Xopenex is used to help you breathe better by opening up your airways. These two types of medications work well together, but they are not the same thing. Xopenex should start to work within minutes and you should start to see an improvement in your symptoms."

Answered by AI

Clinical Trials for Levalbuterol Hydrochloride

Image of Stanford University in Stanford, United States.

MoblO2 for Chronic Lung Diseases

18+

All Sexes

Stanford, CA

Many patients with chronic lung disease (e.g., chronic obstructive pulmonary disease (COPD) or interstitial lung disease (ILD)) require supplemental oxygen (O2) at some point during their disease course. Practitioners prescribe O2 to patients with chronic lung disease in hopes of the following: 1) that it will limit desaturation events and combat breathlessness, thus preventing the frustratingly slow pace and numerous rest breaks patients are forced to adopt while doing even simple tasks; 2) that it will allow patients to be more active physically (perhaps increase their ability to exercise) and socially (perhaps leave the home more often); 3) that it will stave off putative complications of hypoxemia (e.g., cognitive dysfunction, pulmonary hypertension) and 4) that it will improve health-related quality of life (HRQL). However, despite the rationale for O2, and prescribers' good intentions, patients generally view O2 with frustration and fear - it threatens their HRQL, which is already impaired by having a condition that imposes itself on every aspect of their lives. Nasal cannulas and delivery devices call unwanted attention to patients when they are out in public. O2 users feel stigmatized and are often viewed as "smokers who get what they deserve, even if they never smoked a day in their lives" - or as disabled, sick or even infectious. O2 steals patients' independence, forcing them to plan their lives around it. The anxiety that patients and their caregivers experience around running out of oxygen, or not getting enough, immobilizes them and restricts participation in activities outside of the home. O2 disrupts the home environment, adding stress, and creating a burden for patients' caregiver-loved-ones who are often saddled with the responsibility of ensuring adequate equipment and supply of O2, and O2 is a constant reminder to patients they are living with a condition that could shorten their lives. O2 delivery equipment is typically heavy, unwieldy and intimidating. Different recommendations (e.g., insurance companies use 88% as a cut-off for SpO2, while many practitioners focus on 90%) make it confusing for patients, which almost certainly affects adherence. O2-requiringpatients are starving for things that can make their lives easier. An auto-adjusting O2 delivery device - one that automatically delivers the correct amount of O2 to maintain blood oxygen at desired, pre-set levels - would alleviate the need for patients to constantly (incessantly for many) monitor their peripheral oxygen saturation (SpO2) and adjust O2flow to meet the demands as exertion levels vary . The MoblO2 device is a battery-operated, light-weight, closed-loop O2 delivery device that houses a regulator (which attaches to compressed gas O2 tanks) and adjusts O2 flow to meet a pre-set blood oxygen level. A pulse oximeter is worn on the ear and transmits via Bluetooth to the device, which adjusts an internal valve to control flow on a second-to-second basis. The user sets the dial to the highest flow of O2 needed to meet the demands of activities they might perform (up to 15 liters per minute), and the device adjusts flow, up to the pre-set level to maintain SpO2 at a preset level (e.g., \> 90%). To conserve O2 supply in the tank - and to avoid over-oxygenation (which could be problematic for a small percentage of patients with the most severe COPD) - the MoblO2 begins to limit O2 flow at a SpO2 of 93%. The device can be manually over-ridden by the user, and should the battery run out - or the device fail for some unforeseen reason - the default position is valve open, so the users receive whatever flow of oxygen has been set on the dial. Given the substantial burdens of O2 on patients and their families, the hassles patients describe with having to monitor their SpO2 and repeatedly adjust the flow of O2 to meet their needs, patients and experts around the world have called for improvements in O2 delivery equipment. The MoblO2 is just such a remarkable improvement and a giant step forward in helping to ease the burdens of O2 on patients who require it. The purpose of this study is to investigate the effects of the MoblO2 O2 delivery device on a range of outcomes, including physical activity, amount (liters) O2 use; maintenance of adequate SpO2 levels; patient reported outcomes including symptoms, HRQL and satisfaction with the MoblO2 O2 device.

Waitlist Available

Has No Placebo

Stanford UniversityJeff Swigris, DO, MSMinnesota Health Solutions

Have you considered Levalbuterol Hydrochloride clinical trials? We made a collection of clinical trials featuring Levalbuterol Hydrochloride, we think they might fit your search criteria.

Explore trials for Levalbuterol Hydrochloride

Have you considered Levalbuterol Hydrochloride clinical trials? We made a collection of clinical trials featuring Levalbuterol Hydrochloride, we think they might fit your search criteria.