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What is Azelastine Hydrochloride
AzelastineThe Generic name of this drug
Treatment SummaryAzelastine is a medication used to treat allergic and non-allergic rhinitis and allergic conjunctivitis. It is available as a nasal spray and an ophthalmic solution. The drug is a racemic mixture, but both enantiomers have equal effectiveness. Azelastine was approved by the FDA in 1996 and is also available in combination with fluticasone propionate as a nasal spray known as Dymista. This product is approved for people 6 years of age and older who have seasonal allergies.
Astelinis the brand name
Azelastine Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Astelin
Azelastine
1996
56
Effectiveness
How Azelastine Hydrochloride Affects PatientsAzelastine works by blocking the effects of histamine, providing relief from allergy symptoms. When taken in nasal or eye drop form, it will start working within 15 minutes and last for up to 12 hours. The peak effects usually occur 4-6 hours after taking the initial dose.
How Azelastine Hydrochloride works in the bodyAzelastine works by blocking histamine H1-receptors, which are found on nerve endings, smooth muscle cells, and glandular cells. When allergens are present in sensitized individuals, histamine is released and binds to these receptors. This contributes to allergy symptoms like itching, sneezing, and congestion. Azelastine also helps to stabilize mast cells, prevent the release of other inflammation-causing substances, and reduce substances that cause nasal itching and sneezing.
When to interrupt dosage
The measure of Azelastine Hydrochloride is contingent upon the recognized malady, including Hay Fever, Disorder of eye and Keratoconjunctivitis. The extent of dosage fluctuates as per the technique of delivery (e.g. Nasal or Solution / drops) featured in the table beneath.Condition
Dosage
Administration
allergic eye disorders
, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation
, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops, Solution / drops - Intraocular, Spray - Nasal, Spray, Ophthalmic, Solution / drops - Ophthalmic
Hay Fever
, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation
, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops, Solution / drops - Intraocular, Spray - Nasal, Spray, Ophthalmic, Solution / drops - Ophthalmic
Keratoconjunctivitis
, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation
, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops, Solution / drops - Intraocular, Spray - Nasal, Spray, Ophthalmic, Solution / drops - Ophthalmic
Allergic Conjunctivitis (AC)
, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation
, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops, Solution / drops - Intraocular, Spray - Nasal, Spray, Ophthalmic, Solution / drops - Ophthalmic
Blepharitis allergic
, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation
, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops, Solution / drops - Intraocular, Spray - Nasal, Spray, Ophthalmic, Solution / drops - Ophthalmic
Perennial Allergic Rhinitis (PAR)
, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation
, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops, Solution / drops - Intraocular, Spray - Nasal, Spray, Ophthalmic, Solution / drops - Ophthalmic
Allergy to Tree Pollen
, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation
, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops, Solution / drops - Intraocular, Spray - Nasal, Spray, Ophthalmic, Solution / drops - Ophthalmic
Administration, Intranasal
, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation
, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops, Solution / drops - Intraocular, Spray - Nasal, Spray, Ophthalmic, Solution / drops - Ophthalmic
Vasomotor Rhinitis
, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation
, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops, Solution / drops - Intraocular, Spray - Nasal, Spray, Ophthalmic, Solution / drops - Ophthalmic
Warnings
There are 20 known major drug interactions with Azelastine Hydrochloride.Common Azelastine Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Azelastine.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Azelastine.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Azelastine.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Azelastine.
Copanlisib
Major
The metabolism of Copanlisib can be decreased when combined with Azelastine.
Azelastine Hydrochloride Toxicity & Overdose RiskIt is unlikely that taking too much of the azelastine drug through the nose or eyes will cause any serious harm, other than making you more drowsy. If you do take too much, supportive measures should be taken. These products should be kept away from children, as taking too much orally can cause serious side effects in kids. The toxic dose of azelastine in rats is 580 mg/kg.
Azelastine Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Azelastine Hydrochloride?
Currently, nine investigations are underway to evaluate the effectiveness of Azelastine Hydrochloride via Intranasal Administration to combat Allergic Blepharitis and Ocular Disorders.Condition
Clinical Trials
Trial Phases
Allergic Conjunctivitis (AC)
1 Actively Recruiting
Phase 2
Hay Fever
1 Actively Recruiting
Phase 3
Perennial Allergic Rhinitis (PAR)
1 Actively Recruiting
Phase 3
Blepharitis allergic
0 Actively Recruiting
Keratoconjunctivitis
0 Actively Recruiting
Allergy to Tree Pollen
0 Actively Recruiting
Administration, Intranasal
0 Actively Recruiting
allergic eye disorders
0 Actively Recruiting
Vasomotor Rhinitis
0 Actively Recruiting
Azelastine Hydrochloride Reviews: What are patients saying about Azelastine Hydrochloride?
5Patient Review
2/18/2022 I can't believe how well this nasal spray worked for me! I'm 60 years old and have suffered from allergies my whole life, but this is the best medication I've ever used.
5Patient Review
3/5/2022 Almost immediate results if you follow the directions. To those complaining about the taste, read the label!
5Patient Review
4/8/2022 After taking the second dose, I felt a bit chilly.
4.3Patient Review
3/30/2022 I found this to work well for sinus and ocular pressure. It dried out my sinuses and helped thin the mucus so that it could pass more easily. I liked it for seasonal use in teens. It also worked well in combination with antibiotics for ear or sinus infections.The drawbacks are the foul taste and burning, but for me it works better than flonase. I don't really feel tired, at most there's a small buzz and reduced reaction time.
4.3Patient Review
5/21/2022 I've found this to be an effective treatment for post-nasal drip and inflammation. My sinuses feel lighter and I'm sleeping better at night. The only downside is that during the day I sometimes find it hard to move because of the lethargy, but overall I'm grateful for a product that actually works.
4Patient Review
7/5/2021 This helped me a lot with post-nasal drip. The taste isn't great, but it's worth it. Just remember to look down for several minutes after spraying into your nose.
3.3Patient Review
3/8/2022 I have never felt so drowsy in my life. It was like taking sleeping pills. I couldn't figure out why I was so sleepy while driving and ended up going to bed around 5pm. The next day, I woke up at 6am feeling slightly tired. I would not recommend this spray to anyone.
3Patient Review
6/16/2022 I felt relief immediately, which was great. There was an aftertaste that I didn't love, but it wasn't a dealbreaker. A few days in, though, I developed really bad itching in my hands that made the treatment unbearable.
2.3Patient Review
3/25/2022 The burning sensation in my nostril has gotten worse since I started using this product. I would not recommend it to anyone!
2.3Patient Review
11/9/2021 While this did help alleviate some symptoms, it unfortunately also caused my blood pressure and heart rate to increase. If you have any problems with arrhythmia, I'd recommend avoiding this treatment.
1.7Patient Review
6/27/2022 Azelastine unfortunately gave me headaches, so I had to stop using it after only a week. Additionally, everything started smelling strange and tasting terrible. This effect has persisted for a couple months now, and I'm really worried that my sense of smell and taste will never go back to normal. It's driving me crazy not being able to enjoy food like I used to.
1.3Patient Review
12/30/2021 I've tried using this medication for over a year now, and it's been an awful experience. I get horrible sneezing fits, nasal discharge, joint pain, a crawling skin sensation, and a scorched throat that lasts for days. And when the medicine finally kicks in, the relief doesn't last long. Do not recommend.
Patient Q&A Section about azelastine hydrochloride
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is azelastine hydrochloride used for?
"Azelastine nasal spray can help relieve symptoms of seasonal or perennial allergic rhinitis (hay fever), vasomotor rhinitis, or other upper respiratory allergies. Azelastine is an antihistamine."
Answered by AI
What are the side effects of azelastine hydrochloride?
"Some potential side effects of this medication are a bitter taste in the mouth, drowsiness, tiredness, nasal discomfort, sneezing fits, cough, nose bleeds, runny nose, dry mouth, headache, or red eyes. If you experience any of these side effects, tell your doctor or pharmacist."
Answered by AI
Is azelastine HCL a steroid?
"Though azelastine nasal spray is not as strong as intranasal corticosteroids in terms of anti-inflammatory effect, it is still a non-steroidal treatment that has some advantages in the treatment of SAR."
Answered by AI
Is azelastine HCL the same as Flonase?
"Both medications are used to treat allergies, but they work differently.
Are Azelastine (nasal) and Flonase the same medication?
No, Azelastine (nasal) and Flonase are two different medications."
Answered by AI