This trial is evaluating whether Nicotine gum will improve 1 primary outcome and 3 secondary outcomes in patients with Aging. Measurement will happen over the course of Functional MRI recordings will begin approximately 30 minutes after oral administration of polacrilex or placebo gum and will continue for up to two hours..
This trial requires 48 total participants across 4 different treatment groups
This trial involves 4 different treatments. Nicotine Gum is the primary treatment being studied. Participants will be divided into 2 treatment groups. Some patients will receive a placebo treatment. The treatments being tested are in Phase < 1 and are in the first stage of evaluation with people.
"Aging a year is a significant social and economic issue in the United States. As of 2007, about 3.7 million people (10.4% of the population) were projected to be aged 65 or over. In addition, many additional people are projected to grow older due to declining birthrates and rising mortality rates." - Anonymous Online Contributor
"Ageing can not be cured so people should not expect to stay young or be the same age for the rest of their lives. But if the treatment for age-related diseases, such as dementia and Alzheimer's, progresses we may be in a position to treat aging per se once age-related conditions have subsided." - Anonymous Online Contributor
"Almost every type of aging human is treated to address many aspects of aging. Common treatments include supplements, medications, surgery, massage, and physical exercise for older citizens when possible." - Anonymous Online Contributor
"The fundamental question remains: "Why do most individuals become elderly?". There is a growing evidencebase for the proposal that aging is an evolutionary adaptation. The problem remains: evolutionary explanations can only account for two thirds of aging. This question merits further study..." - Anonymous Online Contributor
"Although a number of physiological changes can be found in aging, the greatest changes are in the appearance and behavior of the elderly. In some cases the changes are so great that elderly people have an increased propensity to develop chronic diseases that may limit their physical and mental capacity for many decades." - Anonymous Online Contributor
"This is the first study to show the existence of a distinct signature signature of aging in the human cornea, a tissue that is often used as an ocular age indicator. This signature signature is likely to be unique and reliable to the human cornea. This work highlights the importance of applying aging-associated molecular and cellular biomarkers to study early eye development and aging." - Anonymous Online Contributor
"[Tarexigraf (Bovectin H.S.P. Tarexigraf is a transdermal nicotine gel applied every day that delivers a constant release of nicotine that is about equal to the amount nicotine found in cigarettes (http://www.pnicount.nu.com/item/product_id_3/prodrugs). It is available in the United States and Europe and has been approved by the FDA and the EMA." - Anonymous Online Contributor
"There are many research options to help older adults stay up-top performing on tasks relating to memory, processing speed, mood, physical ability, cognitive function and healthy longevity. The following are examples for aging research\n\n1. Studies have demonstrated the effectiveness of aerobic exercise training programs for maintaining a healthy aging and improving certain aspects of cognitive functioning. The research emphasizes that exercise can be as important as medication in maintaining an elderly patient's mental and physical health.\n\n2." - Anonymous Online Contributor
"A single pack of nicotine replacement therapy was a statistically significant and cost-effective method of reducing the craving for cigarettes. Furthermore, this method had a positive and clinically meaningful benefit on the duration of smoking abstinence." - Anonymous Online Contributor
"Results from a recent clinical trial suggest that serious consequences and adverse outcomes can arise from aging itself or from treatment of aging-associated comorbidities. Appropriate consideration must be made when treating aging-associated diseases in an interdisciplinary context in which the comorbidities are more appropriately addressed." - Anonymous Online Contributor
"More than one of every four patients reported significant side effects. Side effects were mild in most patients. Symptoms such as fatigue (17%) and nausea (15%) were more common among smokers than among non-smokers. Side effects were more common among women compared with men. The common side effects outweighed the benefit for most patients. Smoking is a risk factor for serious side effects. Women, young patients, and young smokers are particularly likely to report a significant number of cough and headache symptoms. In older patients, other serious adverse effects are also possible. Before considering smoking, consult a doctor." - Anonymous Online Contributor
"There were no evidence of age-related heritability from this family-based study. This suggests that age-related effects on disease risk in a typical population may be of little help in identifying the genetic basis of age-related disease in families." - Anonymous Online Contributor