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Intrabronchial Lipopolysaccharide for Acute Respiratory Distress Syndrome

N/A
Waitlist Available
Research Sponsored by National Jewish Health
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age 18-50
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 7 days
Awards & highlights

Study Summary

This trial will test the hypothesis that targeting resident macrophages will differentially impact the resolution of experimental lung injury.

Who is the study for?
This trial is for healthy adults aged 18-50 who haven't used alcohol excessively or any inhaled substances recently. Pregnant or breastfeeding individuals, those with bleeding disorders, immunocompromised conditions, recent illnesses, heart/lung/systemic diseases, abnormal lung function tests or ECGs can't participate.Check my eligibility
What is being tested?
The study involves a bronchoscopy procedure where lipopolysaccharide (a substance that can cause inflammation) is directly placed into the lungs to understand how different types of macrophages contribute to lung repair after injury.See study design
What are the potential side effects?
Potential side effects may include reactions related to bronchoscopy such as coughing, throat irritation and discomfort; and responses to lipopolysaccharide like fever, muscle pain and increased inflammation in the lungs.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 18 and 50 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~7 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 7 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Flow Cytometry

Trial Design

1Treatment groups
Experimental Treatment
Group I: LPS armExperimental Treatment1 Intervention

Find a Location

Who is running the clinical trial?

National Jewish HealthLead Sponsor
140 Previous Clinical Trials
316,211 Total Patients Enrolled

Media Library

Bronchoscopy (Other) Clinical Trial Eligibility Overview. Trial Name: NCT03859050 — N/A
Acute Respiratory Distress Syndrome Research Study Groups: LPS arm
Acute Respiratory Distress Syndrome Clinical Trial 2023: Bronchoscopy Highlights & Side Effects. Trial Name: NCT03859050 — N/A
Bronchoscopy (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03859050 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any available vacancies for this clinical research?

"This experiment, which was initially posted on March 18th 2019 and last updated on August 19th 2019 is currently seeking participants. Data housed by clinicaltrials.gov reflects this status change."

Answered by AI

Are there any eligibility criteria for participants in this research endeavor?

"This clinical trial seeks 25 individuals aged between 18 and 50 who have respiratory distress syndrome. Additionally, each participant must meet the age requirements of this study."

Answered by AI

How many participants have been enrolled in this clinical trial so far?

"Affirmative. According to the information available on clinicaltrials.gov, enrollment into this trial is open and active. It was first made public on March 18th 2019 with its most recent update arriving on August 19th of the same year. 25 participants need to be recruited at just one medical facility for this study."

Answered by AI

Are geriatric individuals outside the age range of 70 eligible for this medical experiment?

"The age requirements for enrolment mandate that participants be between 18 and 50 years old."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Alveolar Macrophage Programming Following Endotoxin Exposure
2019. "Alveolar Macrophage Programming Following Endotoxin Exposure". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03859050.
~4 spots leftby Apr 2025
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