Phyllocontin

Bronchial Spasm, Asthma, Asthma + 4 more
Treatment
20 Active Studies for Phyllocontin

What is Phyllocontin

AminophyllineThe Generic name of this drug
Treatment SummaryAminophylline is a combination of two drugs, theophylline and ethylenediamine, that is used to treat lung diseases like asthma, chronic bronchitis, and COPD. The theophylline works by blocking certain enzymes and receptors in the body and activating histone deacetylases. Although aminophylline has been largely discontinued, some medications are still available but in limited supply.
Aminophyllineis the brand name
Phyllocontin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Aminophylline
Aminophylline
1975
22

Effectiveness

How Phyllocontin Affects PatientsAminophylline is a form of theophylline that helps stimulate the central nervous system, skeletal muscles, and heart muscles. It also relaxes certain muscles in the lungs, increases urine production, and boosts the amount of acid produced in the stomach.
How Phyllocontin works in the bodyAminophylline is a medicine that contains theophylline, which can help relax the airways and blood vessels in your lungs. This helps people with breathing problems, like asthma. Theophylline works by blocking enzymes responsible for breaking down a molecule called cyclic AMP, which causes the airways to constrict. It also blocks adenosine molecules, which can cause bronchoconstriction. In inflammatory states, it can stop genes from being activated that lead to inflammation.

When to interrupt dosage

The measure of Phyllocontin is contingent upon the declared health issue, including Chronic Bronchitis, Lung Disorder and Bronchospasm. The amount of dosage is contingent upon the approach of delivery (e.g. Intravenous or Suppository) indicated in the table underneath.
Condition
Dosage
Administration
Asthma
, 97.5 mg, 225.0 mg, 350.0 mg, 100.0 mg, 200.0 mg, 25.0 mg/mL, 105.0 mg/mL, 500.0 mg, 250.0 mg, 50.0 mg/mL
, Intravenous, Solution, Solution - Intravenous, Oral, Tablet - Oral, Tablet, Tablet, extended release, Injection, solution, Injection, solution - Intravenous, Injection - Intravenous, Rectal, Suppository, Suppository - Rectal, Tablet, extended release - Oral, Solution - Oral, Injection
Bronchitis
, 97.5 mg, 225.0 mg, 350.0 mg, 100.0 mg, 200.0 mg, 25.0 mg/mL, 105.0 mg/mL, 500.0 mg, 250.0 mg, 50.0 mg/mL
, Intravenous, Solution, Solution - Intravenous, Oral, Tablet - Oral, Tablet, Tablet, extended release, Injection, solution, Injection, solution - Intravenous, Injection - Intravenous, Rectal, Suppository, Suppository - Rectal, Tablet, extended release - Oral, Solution - Oral, Injection
Bronchial Spasm
, 97.5 mg, 225.0 mg, 350.0 mg, 100.0 mg, 200.0 mg, 25.0 mg/mL, 105.0 mg/mL, 500.0 mg, 250.0 mg, 50.0 mg/mL
, Intravenous, Solution, Solution - Intravenous, Oral, Tablet - Oral, Tablet, Tablet, extended release, Injection, solution, Injection, solution - Intravenous, Injection - Intravenous, Rectal, Suppository, Suppository - Rectal, Tablet, extended release - Oral, Solution - Oral, Injection
Lung Diseases
, 97.5 mg, 225.0 mg, 350.0 mg, 100.0 mg, 200.0 mg, 25.0 mg/mL, 105.0 mg/mL, 500.0 mg, 250.0 mg, 50.0 mg/mL
, Intravenous, Solution, Solution - Intravenous, Oral, Tablet - Oral, Tablet, Tablet, extended release, Injection, solution, Injection, solution - Intravenous, Injection - Intravenous, Rectal, Suppository, Suppository - Rectal, Tablet, extended release - Oral, Solution - Oral, Injection
Asthma
, 97.5 mg, 225.0 mg, 350.0 mg, 100.0 mg, 200.0 mg, 25.0 mg/mL, 105.0 mg/mL, 500.0 mg, 250.0 mg, 50.0 mg/mL
, Intravenous, Solution, Solution - Intravenous, Oral, Tablet - Oral, Tablet, Tablet, extended release, Injection, solution, Injection, solution - Intravenous, Injection - Intravenous, Rectal, Suppository, Suppository - Rectal, Tablet, extended release - Oral, Solution - Oral, Injection
Bronchitis, Chronic
, 97.5 mg, 225.0 mg, 350.0 mg, 100.0 mg, 200.0 mg, 25.0 mg/mL, 105.0 mg/mL, 500.0 mg, 250.0 mg, 50.0 mg/mL
, Intravenous, Solution, Solution - Intravenous, Oral, Tablet - Oral, Tablet, Tablet, extended release, Injection, solution, Injection, solution - Intravenous, Injection - Intravenous, Rectal, Suppository, Suppository - Rectal, Tablet, extended release - Oral, Solution - Oral, Injection
Asthma
, 97.5 mg, 225.0 mg, 350.0 mg, 100.0 mg, 200.0 mg, 25.0 mg/mL, 105.0 mg/mL, 500.0 mg, 250.0 mg, 50.0 mg/mL
, Intravenous, Solution, Solution - Intravenous, Oral, Tablet - Oral, Tablet, Tablet, extended release, Injection, solution, Injection, solution - Intravenous, Injection - Intravenous, Rectal, Suppository, Suppository - Rectal, Tablet, extended release - Oral, Solution - Oral, Injection

Warnings

There are 20 known major drug interactions with Phyllocontin.
Common Phyllocontin Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Aminophylline.
Amobarbital
Major
The therapeutic efficacy of Amobarbital can be decreased when used in combination with Aminophylline.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Aminophylline.
Barbexaclone
Major
The therapeutic efficacy of Barbexaclone can be decreased when used in combination with Aminophylline.
Barbital
Major
The therapeutic efficacy of Barbital can be decreased when used in combination with Aminophylline.

Phyllocontin Novel Uses: Which Conditions Have a Clinical Trial Featuring Phyllocontin?

158 active studies are currently assessing the potential of Phyllocontin to provide relief for conditions like Bronchitis, Chronic Bronchitis and Asthma.
Condition
Clinical Trials
Trial Phases
Asthma
92 Actively Recruiting
Phase 1, Phase 4, Early Phase 1, Phase 2, Not Applicable, Phase 3
Bronchitis, Chronic
0 Actively Recruiting
Bronchitis
0 Actively Recruiting
Bronchial Spasm
0 Actively Recruiting
Asthma
1 Actively Recruiting
Phase 4
Asthma
4 Actively Recruiting
Not Applicable, Phase 4
Lung Diseases
5 Actively Recruiting
Phase 1, Phase 2, Not Applicable

Phyllocontin Reviews: What are patients saying about Phyllocontin?

5Patient Review
11/13/2015
Phyllocontin for Allergic Asthma that is Resistant to Treatment
Though it took a little over a year for this to start working for me, it has made an incredible difference that has improved my quality of life by 100%. I would highly recommend this drug to others, even though there are some risks associated with taking it.
5Patient Review
6/9/2020
Phyllocontin for Persistent Hives of Unknown Cause
Xolair has been an absolute godsend for me. I suffered from full-body hives for months before trying this, and it was honestly the only thing that worked. It took some time to start seeing results, but once it did, the difference was night and day. I highly recommend giving this a shot if you're struggling with chronic hives like I was.
5Patient Review
10/22/2015
Phyllocontin for Persistent Hives of Unknown Cause
I had my first Xolair injection 5 months ago and it has completely changed my life for the better. I haven't had a single hive since the treatment, which is amazing considering I've been suffering from chronic uticaria for over 7 years. The injections haven't been as costly as I was initially told, which is great. Overall, Xolair has changed my life for the better in so many ways.
5Patient Review
5/29/2019
Phyllocontin for Allergic Asthma that is Resistant to Treatment
This drug has been life-changing for me. I needed my Ventolin inhaler once a week before starting Xolair, and now 2 1/2 months in, I've only used about half of it. I'm more active than ever, and feeling great!
5Patient Review
7/3/2018
Phyllocontin for Allergic Asthma that is Resistant to Treatment
My blood test results improved after I started taking this medication, so my doctor in Nevada decided to take me off of it.
4.7Patient Review
6/17/2015
Phyllocontin for Allergic Asthma that is Resistant to Treatment
Xolair has been a complete game-changer for me. I've had asthma since I was two years old, and it used to flare up every evening no matter what medication or inhaler I was using. Xolair keeps me breathing freely and also helps with my seasonal allergies. It's not the most convenient treatment – I have to drive 30 minutes each way to get injections every two weeks – but it's worth it.
4.7Patient Review
2/16/2016
Phyllocontin for Allergic Asthma that is Resistant to Treatment
This injection has been a lifesaver for me. I've been taking it monthly for severe asthma for several years, and it's helped me immensely. I rarely need prednisone now, and while the injections can be a bit of a hassle to order and time, they're definitely worth it.
3.7Patient Review
8/16/2015
Phyllocontin for Allergic Asthma that is Resistant to Treatment
I've been having these injections for a little less than a year now, and at first they were great. But the last three times, I've had really severe asthma attacks the day after the injection that have taken weeks to recover from using Dacortin (prednisona). I'm going to talk to my consultant about it before getting the next injection. Has anyone else experienced this?
3Patient Review
10/26/2022
Phyllocontin for moderate persistent asthma
I took this medication because I am struggling with asthma and chronic urticaria. However, after the second day I started to experience chest tightness, diarrhea, and an increased heart rate. This was all very new to me as I've never tried this injection before.
2.7Patient Review
5/27/2019
Phyllocontin for Allergic Asthma that is Resistant to Treatment
The vial works great, but the pre-filled syringe is not very effective.
2.3Patient Review
3/2/2021
Phyllocontin for Persistent Hives of Unknown Cause
The price is outrageous. My daughter needs two injections per month, and they're each a thousand dollars. We just had sample shots; I don't know if it works yet.
2.3Patient Review
9/24/2015
Phyllocontin for Persistent Hives of Unknown Cause
I've had UCIs for about 10 years now, and no doctor has been able to tell me why. I was told that Xolair would be my cure, but after six shots, I'm still getting them just as frequently as before. Not only is this treatment ineffective, it's also very expensive.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about phyllocontin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is there an alternative to Phyllocontin?

"If your doctor has prescribed Phyllocontin® for your asthma, they will contact you about your treatment options, which may include switching to Uniphyllin Continus, an alternative theophylline medication."

Answered by AI

Is Phyllocontin an aminophylline?

"Phyllocontin is a medication used to treat and prevent bronchospasm, a condition in which the airways of the lungs narrow. It is used in adults for the treatment and prevention of bronchospasm associated with conditions such as asthma, chronic obstructive pulmonary disease, and chronic bronchitis. For children, it is used to manage asthma."

Answered by AI

What is Phyllocontin used for?

"Aminophylline is an ingredient in these tablets that are used to treat asthma, long-term breathing difficulties, and sometimes heart failure in adults. These tablets belong to a group of medicines called bronchodilators."

Answered by AI

When was Phyllocontin discontinued?

"The Department of Health and Social Care announced on February 12th that Phyllocontin® will be discontinued in the UK. The stock of 225mg tablets is expected to be exhausted by 30th March 2021 and the 350mg tablets is expected to be exhausted by 5th April 2021."

Answered by AI

Clinical Trials for Phyllocontin

Image of UPMC Children's Hospital of Pittsburgh in Pittsburgh, United States.

AQI Information for Asthma

8 - 17
All Sexes
Pittsburgh, PA
The goal of this clinical trial is to learn if adding Air Quality Index (AQI) information to asthma action plans works to improve asthma outcomes in children. It will also learn about children with asthma who report being more sensitive to outdoor air pollution. The main questions it aims to answer are: * Does adding either information about the EPA-AQI or commercial AQI improve asthma outcomes over time? * Are there changes in nasal gene expression in children with asthma who report they are more sensitive to outdoor air pollution? Researchers will compare EPA-AQI and the commercial-AQI groups to a control group to either AQI works to improve asthma. Participants will: * Receive standardized outdoor air pollution education and an asthma action plan * Provide nose and blood specimens * Have visits every 4 weeks for 48 weeks, 10 will be conducted by telephone calls and 3 visits will be in person.
Waitlist Available
Has No Placebo
UPMC Children's Hospital of PittsburghFranziska Rosser, MD MPH
Have you considered Phyllocontin clinical trials? We made a collection of clinical trials featuring Phyllocontin, we think they might fit your search criteria.Go to Trials
Image of Allergy Immunology Associates in Mayfield Heights, United States.

Osteopathic Manipulative Treatment for Asthma

18 - 60
All Sexes
Mayfield Heights, OH
Asthma is a common respiratory condition that can be difficult to control despite the use of medications such as inhalers, oral steroids or even injectable medications. Osteopathic Manipulative Treatment (OMT) is a hands-on technique used to improve the chest structure and function and may help in improving breathing. Previous research showed that OMT in asthma patients, can improve the movement of the ribs and improve the "peak flow" which is the maximum rate at which a person can exhale air after taking a deep breath. However, no studies have evaluated the impact of OMT on lung inflammation. This single-site research study at University Hospitals aims to evaluate whether Osteopathic Manipulative Treatment (OMT) can reduce lung inflammation and improve breathing and lung function in adult patients with asthma. The lung function will be evaluated by Spirometry which is a test that measures how much air you can breathe in and out of your lungs, as well as how quickly and easily you can exhale air. The lung inflammation will be measured using a device that can detect how much you are breathing out Nitric Oxide which is a gas produced by inflamed cells in the lungs, this test is called: Fractional exhaled Nitric Oxide or FeNO. Approximately 100 participants will be enrolled.
Waitlist Available
Has No Placebo
Allergy Immunology AssociatesNancy Wasserbauer-Kingston, DO
Image of DARTNet Institute in Aurora, United States.

Inhaled Corticosteroids + Azithromycin for Asthma

13 - 75
All Sexes
Aurora, CO
While asthma therapy is becoming more individualized based on asthma phenotypes, more research is needed to tailor newer therapies to individuals. Inhaled corticosteroid (ICS) medications are the foundation of care for all individuals with persistent asthma. But ICS use is not without possible long term side effects. This study will compare two currently available approaches to reduce AEX in primary care patients: (1) use of inhaled corticosteroids (ICS) as part of rescue therapy, also known as MART (Maintenance And Reliever Therapy) or PARTICS (Patient Activated Reliever Trigger Inhaled Corticosteriods) therapy - either of these therapies will be called Rescue-Inhaled Corticosteroids or R-ICS pronounced "Ricks," and (2) use of azithromycin (AZ) as a preventive therapy. These treatments will be studied both individually and in combination.
Phase 4
Recruiting
DARTNet Institute (+12 Sites)Wilson D Pace, MD, FAAFP
Image of Medical Place Pharmacy in Ajax, Canada.

Pharmacy Support System for Asthma

Any Age
All Sexes
Ajax, Canada
The goal of this study is to assess the effect of an electronic asthma management system in pharmacies (eAMS-Pharm) on asthma control assessment, asthma medication adjustment, asthma action plan delivery, and prompting for specialist referral in severe asthma. The study assesses the differences on pharmacy processes (affecting both the pharmacy team and patients) and pharmacy-delivered care using an interrupted time-series analysis (six-months before vs. six-months after the introduction of eAMS-Pharm in study pharmacy sites). The eAMS-Pharm uses patient data (asthma control, asthma flare-up risk, and current medications) to provide clinical decision support to pharmacists, empowering them to bridge existing gaps between guideline-recommended asthma care and patient care received.
Waitlist Available
Has No Placebo
Medical Place Pharmacy (+2 Sites)
Have you considered Phyllocontin clinical trials? We made a collection of clinical trials featuring Phyllocontin, we think they might fit your search criteria.Go to Trials
Image of Velocity Clinical Research, Mobile in Mobile, United States.

PF-07275315 for Asthma

18 - 70
All Sexes
Mobile, AL
The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called PF-07275315) for the potential treatment of moderate-to-severe asthma. Asthma is a condition that makes it challenging to breathe, which negatively impacts the quality of life and functioning of people who are affected. This study is seeking participants who: * Are 18 to 70 years old * Have had moderate-to-severe asthma for at least 12 months that is not well controlled * Have been taking their regular maintenance treatment(s) for asthma over the last 12 months All participants will receive PF-07275315 or a placebo. A placebo does not have any medicine in it but looks just like the medicine being studied. PF-07275315 or placebo will be given as multiple shots in the clinic over the course of 12 weeks. We will compare the experiences of people receiving PF-07275315 to those of the people who do not. This will help us determine if PF-07275315 is safe and effective. Participants will be involved in this study for about 9.5 months. During this time, they will have 10 visits at the study clinic.
Phase 2
Recruiting
Velocity Clinical Research, Mobile (+10 Sites)Pfizer CT.gov Call CenterPfizer
Image of St. Joseph's Healthcare Hamilton in Hamilton, Canada.

Corticosteroids for Asthma

18+
All Sexes
Hamilton, Canada
Most individuals with asthma can effectively manage their symptoms and maintain normal lung function using inhaled medications, unfortunately, there is a subset of asthma sufferers whose symptoms, lung function, and risk of asthma attacks remain unimproved despite conventional inhaled medications. There could be several reasons for this. One possibility is that inhaled medications fail to reach the intended areas within the lungs, due to structural abnormalities within the airways themselves. Much like road conditions or closures can impede the speed and efficiency of vehicle travel, factors such as airway narrowing or mucus blockages, which are common in asthma, can obstruct the passage of inhaled medications through the airways. Our team has now optimized advanced medical imaging techniques, including magnetic resonance imaging (MRI) and computed tomography (CT), required to investigate this. This study will use these imaging methods to visually assess and measure individual patients' airways and determine whether abnormal airway structures impact how well they respond to inhaled and orally delivered medications. We anticipate finding that abnormal airway structures make inhaled medications less effective, but that they do not affect the response to oral medications.
Phase 4
Recruiting
St. Joseph's Healthcare Hamilton (+1 Sites)
Have you considered Phyllocontin clinical trials? We made a collection of clinical trials featuring Phyllocontin, we think they might fit your search criteria.Go to Trials
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