AQI Information for Asthma

(PIKAS Trial)

Overseen By Pediatric Asthma Center

Age: < 18

Sex: Any

Trial Phase: Academic

Sponsor: University of Pittsburgh

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

What You Need to Know Before You Apply

What is the purpose of this trial?

The goal of this clinical trial is to learn if adding Air Quality Index (AQI) information to asthma action plans works to improve asthma outcomes in children. It will also learn about children with asthma who report being more sensitive to outdoor air pollution. The main questions it aims to answer are:

* Does adding either information about the EPA-AQI or commercial AQI improve asthma outcomes over time?

* Are there changes in nasal gene expression in children with asthma who report they are more sensitive to outdoor air pollution?

Researchers will compare EPA-AQI and the commercial-AQI groups to a control group to either AQI works to improve asthma.

Participants will:

* Receive standardized outdoor air pollution education and an asthma action plan

* Provide nose and blood specimens

* Have visits every 4 weeks for 48 weeks, 10 will be conducted by telephone calls and 3 visits will be in person.

Who Is on the Research Team?

Franziska Rosser, MD MPH

Principal Investigator

University of Pittsburgh

Are You a Good Fit for This Trial?

This trial is for children with asthma who feel their condition gets worse with outdoor air pollution. They must be willing to follow an asthma action plan, provide nose and blood samples, and commit to regular visits over a year.

Inclusion Criteria

Home access to a smartphone or internet

Primary residence in Allegheny County, PA

One participant per household

Exclusion Criteria

Current participation in another asthma intervention trial

Plans to relocate from Allegheny County, PA in the next year (12 months)

I do not have any active chronic respiratory diseases like cystic fibrosis.

What Are the Treatments Tested in This Trial?

Interventions

• Commercial-AQI
• Education and plan
• EPA-AQI

Trial Overview The study tests if adding Air Quality Index (AQI) information from the EPA or commercial sources to asthma plans helps improve health outcomes. It involves education on pollution, comparing two AQI groups against a control group without AQI data.

How Is the Trial Designed?

Group I: EPA-AQI (Education+ plan + EPA-AQI) Experimental Treatment 2 Interventions

EPA-AQI

Group II: Commercial-AQI (Education+ plan + commercial-AQI) Experimental Treatment 2 Interventions

Commercial-AQI

Group III: Control (Standard outdoor air pollution education + asthma action plan) Active Control 1 Intervention

Control

Who Is Running the Clinical Trial?

University of Pittsburgh

Lead Sponsor

Trials

1,820

Recruited

16,360,000+

National Institute of Environmental Health Sciences (NIEHS)

Collaborator

Trials

294

Recruited

1,233,000+