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LPS for Major Depressive Disorder
Study Summary
This trial is testing whether lipopolysaccharide (LPS) can help treat major depressive disorder (MDD). LPS is a molecule found on the outside of some types of bacteria. The trial will enroll 180 participants, 90 with MDD and 90 healthy controls (HC). Participants will be randomly assigned to receive either LPS or a placebo. The trial has three main aims: to identify immune pathways and neural circuits that respond differently to LPS in MDD vs. HC subjects; (2) to test whether the strength of inflammatory changes induced by LPS is associated with degree of change in anhedonic symptoms and neural circuits in the
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2016 Phase 4 trial • 16 Patients • NCT02875028Trial Design
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Logistics
Participation is compensated
You will be compensated for participating in this trial.
Who is running the clinical trial?
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- I am between 18 and 65 years old and in good health.I do not speak English.I am not taking hormone meds, steroids, NSAIDs, immune drugs, painkillers, heart drugs, antibiotics, or using recreational drugs.I am between 18-65, in good health, and have been diagnosed with depression.I arrived with high or low blood pressure, irregular heartbeat, and fever.I have not had severe thoughts of or attempts at suicide in the last year.My current depression symptoms have been evaluated by a doctor.I have a long-term infection or a recent illness caused by an infection.I have a brain injury or disorder that affects my thinking or memory.I have other health issues like heart or nerve problems, pain conditions, or inflammation.My BMI is over 35, and I might have abnormal lab tests or EKG results.I have been diagnosed with depression based on my PHQ-9 or MADRS scores.
- Group 1: LPS
- Group 2: Placebo
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
How many participants are actively engaged in this clinical research project?
"Affirmative. Records from clinicaltrials.gov indicate that this research initiative, which was initially created on May 15th 2021, is still seeking participants. This medical trial requires 180 individuals across 1 site to partake in the study."
Who satisfies the criteria for enrollment in this medical experiment?
"This medical trial seeks 180 individuals suffering from MDD and aged between 18 to 65. In order to qualify, applicants must meet these two criteria."
Is the eligibility criteria for this research inclusive of individuals over 40 years old?
"The eligibility criteria for this medical trial requires that participants be over the age of consent and under 65 years old."
Are medical centers currently accepting enrollees for this experiment?
"Affirmative. Details on clinicaltrials.gov indicate that this medical experiment is actively recruiting participants, with 180 individuals needed from a single site. The trial was first posted May 15th 2021 and last modified June 29th 2022."
Who else is applying?
What state do they live in?
How old are they?
What site did they apply to?
What portion of applicants met pre-screening criteria?
How many prior treatments have patients received?
Why did patients apply to this trial?
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