Radiation Therapy for Bone Metastases
Trial Summary
What is the purpose of this trial?
To compare increasing doses and different treatment schedules of stereotactic body radiation therapy (SBRT) against standard treatment scheduling.
Will I have to stop taking my current medications?
The trial does not specify that you need to stop taking your current medications. In fact, you may continue systemic therapies like chemotherapy or immunotherapy during the trial, as long as your doctor agrees.
What data supports the effectiveness of this treatment for bone metastases?
Intraoperative radiotherapy (IORT), a component of the treatment, has shown effectiveness in improving local control and survival in various cancers, including breast cancer and recurrent colorectal cancers, by delivering precise radiation doses during surgery. This suggests potential benefits for bone metastases by targeting tumors directly while minimizing damage to surrounding healthy tissues.12345
Is radiation therapy generally safe for humans?
Radiation therapy, including techniques like image-guided radiotherapy (IGRT) and intensity-modulated radiation therapy (IMRT), is generally considered safe when performed by qualified professionals with proper safety measures in place. Studies have shown that these techniques can minimize damage to normal tissues, although they do come with specific safety concerns that require careful management.678910
How is radiation therapy unique for treating bone metastases?
Radiation therapy for bone metastases, especially using advanced techniques like stereotactic body radiotherapy (SBRT) and intensity-modulated radiotherapy (IMRT), allows for precise targeting of tumors with high doses, minimizing damage to surrounding healthy tissue and potentially providing better pain relief and tumor control compared to conventional methods.1112131415
Research Team
Quynh Nguyen,, M D
Principal Investigator
M.D. Anderson Cancer Center
Eligibility Criteria
This trial is for adults with solid primary malignancies and bone metastases, who have a life expectancy of at least 3 months. They must have adequate organ function, agree to use contraception if of childbearing potential, and be able to complete surveys. Excluded are pregnant individuals, those with prior radiation or certain treatments at the site, spinal metastases not invading paraspinal region or mechanically unstable fractures.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either standard dose or high dose radiation therapy for bone metastases
Follow-up
Participants are monitored for pain response and other outcomes post-treatment
Long-term follow-up
Participants are monitored for long-term outcomes such as survival and toxicity
Treatment Details
Interventions
- Radiation Therapy
Radiation Therapy is already approved in European Union, United States, Canada, Japan, China, Switzerland for the following indications:
- Cancer treatment
- Palliative care
- Oropharyngeal cancer
- Breast cancer
- Prostate cancer
- Lung cancer
- Brain tumors
- Cancer treatment
- Palliative care
- Oropharyngeal cancer
- Breast cancer
- Prostate cancer
- Lung cancer
- Brain tumors
- Cancer treatment
- Palliative care
- Oropharyngeal cancer
- Breast cancer
- Prostate cancer
- Lung cancer
- Brain tumors
- Cancer treatment
- Palliative care
- Oropharyngeal cancer
- Breast cancer
- Prostate cancer
- Lung cancer
- Brain tumors
- Cancer treatment
- Palliative care
- Oropharyngeal cancer
- Breast cancer
- Prostate cancer
- Lung cancer
- Brain tumors
- Cancer treatment
- Palliative care
- Oropharyngeal cancer
- Breast cancer
- Prostate cancer
- Lung cancer
- Brain tumors
Find a Clinic Near You
Who Is Running the Clinical Trial?
M.D. Anderson Cancer Center
Lead Sponsor