pembrolizumab for Mesothelioma
Malignant Pleural Disease Treated With Autologous T Cells Genetically Engineered to Target the Cancer-Cell Surface Antigen Mesothelin
See full descriptionAbout the trial for Mesothelioma
Treatment Groups
This trial involves 3 different treatments. Pembrolizumab is the primary treatment being studied. Participants will be divided into 3 treatment groups. There is no placebo group. The treatments being tested are in Phase 1 & 2 and have already been tested with other people.
About The Treatment
Eligibility
This trial is for patients born any sex aged 18 and older. You must have received 1 prior treatment for Mesothelioma or one of the other 5 conditions listed above. There are 10 eligibility criteria to participate in this trial as listed below.
Approximate Timelines
Measurement Requirements
This trial is evaluating whether pembrolizumab will improve 2 primary outcomes and 1 secondary outcome in patients with Mesothelioma. Measurement will happen over the course of at 12 weeks following the first dose of pembrolizumab.
Patient Q & A Section
Can mesothelioma be cured?
Symptoms can be eliminated in a significant number of malignant mesotheliomas provided that patients are treated as early as possible and with the utmost efficiency and speed. However, curative measures do not allow for cure of this malignant tumour.
How many people get mesothelioma a year in the United States?
Approximately 5-6,000 people are diagnosed with mesothelioma a year in the United States. This makes it a rare disease that causes around 2,800 deaths a year in the US. meso<nowiki>'</nowiki>sothelioma does not only kill people by causing suffocation but can also kill through its toxic side effects.\nquestion: How many people get [breast cancer](https://www.withpower.com/clinical-trials/breast-cancer) a year in the United States?\nanswer: In 2013, approximately 1,430,500 women were diagnosed with breast cancer in the United States. This makes it one of the most common cancer among women in the United States.
What causes mesothelioma?
Mesothelioma can occur at multiple sites in the body, and it can occur at all levels of the respiratory tract. The most common occurrence is in the thoracic cavity, due to exposure to asbestos. Mesothelioma can spread from the lung to other organs and is often accompanied by malignant pleural mesothelioma. Mesothelioma is a rare cancer, but it has a high prevalence in certain parts of the world, and it is diagnosed in many people. Most patients have the disease for five to 10 years before the diagnosis is made.
What are common treatments for mesothelioma?
Treatment is dependent on the stage of disease, symptoms, and prognosis. A prospective clinical trial would reveal the best treatment to be used and the best stage of disease to avoid. mesothelioma.
What are the signs of mesothelioma?
The signs of mesothelioma include weight loss, fatigue, loss of appetite etc. The cancer may be mistaken in the medical history for benign disease, thus leading to further delay in diagnosis and treatment.
What is mesothelioma?
A mesothelium is a thin waxy membranous covering that envelops the visceral and/or parietal peritoneum that protects its function. Mesothelium forms the lining that covers the inner (and some of the outer) surfaces of the cavities in the human body, particularly blood vessels. Mesothelioma is most often caused by asbestos exposure. It can also occur from exposure to asbestos-containing products. Mesothelioma's appearance depends on the location in the body that is affected. Mesotheliomas most often occur in the abdomen (or abdomen part of the thorax), thorax, and on the neck (or neck part of the thorax).
What is the primary cause of mesothelioma?
Data from a recent study shows that mesothelioma can occur independently in both genders and in all segments of the population, in all age groups and the elderly also get mesothelioma. The overall survival of patients with mesothelioma is very poor, especially in females. Data from a recent study shows that the incidence and outcome of mesothelioma cases were different in different countries and in different areas of the country as well, which would be due to the environmental influence of asbestos dusts.
What is the latest research for mesothelioma?
It is important that people get tested for cancer, even if they think it is an 'old disease' like mesothelioma. In addition to screening, it is also recommended to be checked over time, with regular examination, X-ray analysis and medical imaging. For women, breast screenings are advised more frequently, particularly during pregnancy. And for people of all ages, cancer screening programs can be valuable for assessing risk factors and for detecting early signs and symptoms of cancer.
What does pembrolizumab usually treat?
Pembrolizumab treatment usually results in improvement in symptoms, including the sensation of weight loss. However, most patients develop progressive disease, and experience a decrease in time to progression and progression-free survival. Patients should understand that despite a change in the pattern of symptoms to a more favorable one, there is no change in the rate of progression or overall survival. These data suggest that treatment with pembrolizumab should be discontinued or discontinued early in patients with progression in order to maximize survival.
What is the survival rate for mesothelioma?
Survival rates are highly variable between patients with different stages and different types of the disease. Typically, early stage is associated with better survival. However, some patients with more advanced disease can have survival rates of 50% to 100%. Patients must understand survival rates vary widely depending on how they are diagnosed, when they seek treatment, and how well they’re treated once they arrive at the hospital. Although lung and heart are the most common sites for mesothelioma, a small number of cases come from a number of other organs. The most common site is the diaphragm; a small number come from the liver, ovaries, and even the adrenal glands.
Have there been any new discoveries for treating mesothelioma?
In a recent study, findings showed that many studies used insufficient and non-quality research methodology methods. We also suggest the need for more studies, and more scientific research, on the treatments of mesothelioma.
What are the chances of developing mesothelioma?
It is important for physicians to be vigilant around diagnosis and treatment of mesothelioma. In certain populations, however, the risk of developing mesothelioma is increased. These individuals are candidates to be examined for symptoms of asbestos exposure, and/or examination of the pleura, if possible.