Exercise for Reducing Breast Cancer Risk
(ACE Trial)
Trial Summary
What is the purpose of this trial?
This trial studies how a 45-minute bout of acute exercise in women with a history of breast cancer can affect factors associated with breast cancer and help doctors learn more about how exercise can help prevent breast cancer. In an earlier part of the study, investigators looked at the effects of the same intervention in women without a history of cancer.
Research Team
Anne McTiernan
Principal Investigator
Fred Hutch/University of Washington Cancer Consortium
Eligibility Criteria
This trial is for women aged 36-75, postmenopausal, who are healthy or have had Stage 0-IIIc breast cancer within the last 5 years and finished treatment at least 6 months ago. Participants must live in the greater Seattle area, be able to attend clinic visits, understand English instructions and questionnaires, and provide consent. Exclusions include certain genetic syndromes like Li-Fraumeni Syndrome, diabetes, heavy alcohol use (>2 drinks/day), tobacco use, drug abuse or significant mental illness.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo a 45-minute bout of moderate-intensity acute exercise or rest
Follow-up
Participants are monitored for changes in biomarkers up to 105 minutes after intervention
Extension
Participants may opt into an extension phase involving exercise or rest for 45 minutes
Treatment Details
Interventions
- Exercise Intervention
Find a Clinic Near You
Who Is Running the Clinical Trial?
Fred Hutchinson Cancer Research Center
Lead Sponsor
Fred Hutchinson Cancer Center
Lead Sponsor
Breast Cancer Research Foundation
Collaborator