112 Participants Needed

Exercise for Reducing Breast Cancer Risk

(ACE Trial)

AM
CD
Overseen ByCatherine Duggan
Age: 18+
Sex: Female
Trial Phase: Academic
Sponsor: Fred Hutchinson Cancer Research Center
Must be taking: Anti-estrogen therapy
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

What is the purpose of this trial?

This trial studies how a 45-minute bout of acute exercise in women with a history of breast cancer can affect factors associated with breast cancer and help doctors learn more about how exercise can help prevent breast cancer. In an earlier part of the study, investigators looked at the effects of the same intervention in women without a history of cancer.

Research Team

AM

Anne McTiernan

Principal Investigator

Fred Hutch/University of Washington Cancer Consortium

Eligibility Criteria

This trial is for women aged 36-75, postmenopausal, who are healthy or have had Stage 0-IIIc breast cancer within the last 5 years and finished treatment at least 6 months ago. Participants must live in the greater Seattle area, be able to attend clinic visits, understand English instructions and questionnaires, and provide consent. Exclusions include certain genetic syndromes like Li-Fraumeni Syndrome, diabetes, heavy alcohol use (>2 drinks/day), tobacco use, drug abuse or significant mental illness.

Inclusion Criteria

All race and ethnic groups are eligible for the study
I finished my main cancer treatment over 6 months ago.
Willing to consent to release of medical records for their breast cancer diagnosis and treatment
See 11 more

Exclusion Criteria

History of clotting disorders (muscle-biopsy sub study)
I have a family history of breast cancer.
I carry a BRCA 1 or BRCA 2 gene mutation.
See 31 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Treatment

Participants undergo a 45-minute bout of moderate-intensity acute exercise or rest

1 day
1 visit (in-person)

Follow-up

Participants are monitored for changes in biomarkers up to 105 minutes after intervention

105 minutes

Extension

Participants may opt into an extension phase involving exercise or rest for 45 minutes

1 day
1 visit (in-person)

Treatment Details

Interventions

  • Exercise Intervention
Trial Overview The study examines how a single session of acute exercise affects factors related to breast cancer risk in both healthy participants and breast cancer survivors. It involves resting periods as well as exercise intervention followed by biomarker analysis and questionnaire administration.
Participant Groups
2Treatment groups
Experimental Treatment
Active Control
Group I: Arm I (acute exercise)Experimental Treatment3 Interventions
Participants undergo a moderate-intensity acute exercise bout over 45 minutes.
Group II: Arm II (rest)Active Control3 Interventions
Participants rest by sitting for 45 minutes.

Find a Clinic Near You

Who Is Running the Clinical Trial?

Fred Hutchinson Cancer Research Center

Lead Sponsor

Trials
444
Recruited
148,000+

Fred Hutchinson Cancer Center

Lead Sponsor

Trials
583
Recruited
1,341,000+

Breast Cancer Research Foundation

Collaborator

Trials
79
Recruited
40,500+
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top
Terms of Service·Privacy Policy·Cookies·Security