Palladone

Neuropathic Pain, Coughing, Pain
Treatment
20 Active Studies for Palladone

What is Palladone

HydromorphoneThe Generic name of this drug
Treatment SummaryHydromorphone is a powerful opioid pain reliever first used in 1920. It is derived from morphine, but with a few modifications that make it much stronger. Because of its high potency and potential for addiction, hydromorphone is classified as a Schedule II controlled substance. Hydromorphone hydrochloride was first approved by the FDA in 1984 and is available in many forms.
Dilaudidis the brand name
image of different drug pills on a surface
Palladone Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Dilaudid
Hydromorphone
1926
167

Effectiveness

How Palladone Affects PatientsHydromorphone has been found to be an effective pain reliever for those who cannot tolerate the side effects of morphine, or those with renal failure or asthma. It is more powerful than morphine, and has a shorter duration of pain relief. When used for acute pain, hydromorphone can cause respiratory depression, slowed thinking, constricted pupils, low blood pressure, dizziness, and vertigo. It also causes less itching and nausea than other pain relievers like meperidine, morphine, diamorphine, bupivacaine, indomethacin, and fentanyl. The respiratory depression is thought to be caused by
How Palladone works in the bodyHydromorphone is a type of opioid medication that is used to reduce pain. It works by binding to mu-opioid receptors, which are located in the brain and spinal cord. Hydromorphone can also depress the respiratory drive and suppress coughs. The effects of the immediate release form of hydromorphone can be felt in about 15-20 minutes and will last for 3-4 hours, while the extended-release form can take effect in 6 hours and remain in the body for 13 hours.

When to interrupt dosage

The proposed dosage of Palladone is contingent upon the determined ailment, comprising Neuropathic Pain, Coughing and Pain. The measure of dosage differs, depending on the method of administration (e.g. Tablet - Oral or Tablet, extended release - Oral) indicated in the table beneath.
Condition
Dosage
Administration
Neuropathic Pain
8.0 mg, , 12.0 mg, 16.0 mg, 32.0 mg, 3.0 mg, 2.0 mg/mL, 2.0 mg, 10.0 mg/mL, 4.0 mg, 5.0 mg/mL, 0.2 mg/mL, 0.1 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 0.4 mg/mL, 1.0 mg, 6.0 mg, 24.0 mg, 30.0 mg, 18.0 mg, 4.5 mg, 9.0 mg, 250.0 mg, 4.0 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 20.0 mg/mL, 100.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Intramuscular; Intravenous; Subcutaneous, Injection, Injection - Intramuscular; Intravenous; Subcutaneous, Tablet, Tablet - Oral, Parenteral, Injection - Parenteral, Solution, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous; Subcutaneous, Syrup, Syrup - Oral, Solution - Intramuscular; Intravenous; Subcutaneous, Capsule, extended release, Capsule, extended release - Oral, Powder, for solution - Intramuscular; Intravenous; Subcutaneous, Powder, for solution, Liquid, Liquid - Intramuscular; Intravenous; Subcutaneous, Liquid - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Powder, Powder - Intramuscular; Intravenous; Subcutaneous, Solution - Intravenous
Coughing
8.0 mg, , 12.0 mg, 16.0 mg, 32.0 mg, 3.0 mg, 2.0 mg/mL, 2.0 mg, 10.0 mg/mL, 4.0 mg, 5.0 mg/mL, 0.2 mg/mL, 0.1 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 0.4 mg/mL, 1.0 mg, 6.0 mg, 24.0 mg, 30.0 mg, 18.0 mg, 4.5 mg, 9.0 mg, 250.0 mg, 4.0 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 20.0 mg/mL, 100.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Intramuscular; Intravenous; Subcutaneous, Injection, Injection - Intramuscular; Intravenous; Subcutaneous, Tablet, Tablet - Oral, Parenteral, Injection - Parenteral, Solution, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous; Subcutaneous, Syrup, Syrup - Oral, Solution - Intramuscular; Intravenous; Subcutaneous, Capsule, extended release, Capsule, extended release - Oral, Powder, for solution - Intramuscular; Intravenous; Subcutaneous, Powder, for solution, Liquid, Liquid - Intramuscular; Intravenous; Subcutaneous, Liquid - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Powder, Powder - Intramuscular; Intravenous; Subcutaneous, Solution - Intravenous
Pain
8.0 mg, , 12.0 mg, 16.0 mg, 32.0 mg, 3.0 mg, 2.0 mg/mL, 2.0 mg, 10.0 mg/mL, 4.0 mg, 5.0 mg/mL, 0.2 mg/mL, 0.1 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 0.4 mg/mL, 1.0 mg, 6.0 mg, 24.0 mg, 30.0 mg, 18.0 mg, 4.5 mg, 9.0 mg, 250.0 mg, 4.0 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 20.0 mg/mL, 100.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Intramuscular; Intravenous; Subcutaneous, Injection, Injection - Intramuscular; Intravenous; Subcutaneous, Tablet, Tablet - Oral, Parenteral, Injection - Parenteral, Solution, Solution - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous; Subcutaneous, Syrup, Syrup - Oral, Solution - Intramuscular; Intravenous; Subcutaneous, Capsule, extended release, Capsule, extended release - Oral, Powder, for solution - Intramuscular; Intravenous; Subcutaneous, Powder, for solution, Liquid, Liquid - Intramuscular; Intravenous; Subcutaneous, Liquid - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Powder, Powder - Intramuscular; Intravenous; Subcutaneous, Solution - Intravenous

Warnings

Palladone has twelve contra-indications and should not be administered with any of the conditions in the accompanying table.Palladone Contraindications
Condition
Risk Level
Notes
Mental Depression
Do Not Combine
narrowing of gastrointestinal tract caused by underlying disease
Do Not Combine
suspected gastrointestinal obstruction
Do Not Combine
opioid intolerance
Do Not Combine
depressed ventilatory function
Do Not Combine
"blind loops" of the gastrointestinal tract
Do Not Combine
Bronchial Asthma
Do Not Combine
intracranial lesion
Do Not Combine
Esophageal Stenosis
Do Not Combine
Paralytic Ileus
Do Not Combine
Gastrointestinal obstruction
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Hydromorphone may interact with Pulse Frequency
There are 20 known major drug interactions with Palladone.
Common Palladone Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Hydromorphone may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Eluxadoline
Major
The risk or severity of constipation can be increased when Hydromorphone is combined with Eluxadoline.
Ethanol
Major
Hydromorphone may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Methylene blue
Major
Hydromorphone may increase the serotonergic activities of Methylene blue.
Mirtazapine
Major
Hydromorphone may increase the serotonergic activities of Mirtazapine.
Palladone Toxicity & Overdose RiskThe toxic dose of hydromorphone in mice is 104mg/kg when taken intravenously and 84mg/kg when taken orally. Overdosing on hydromorphone can cause shallow breathing, sleepiness, weak muscles, cold and clammy skin, constricted pupils, low blood pressure, and even death. Treatment may involve using a ventilator, supportive care, and CPR. Naloxone may be used to reverse respiratory depression. Hydromorphone has not been linked to mutations or cancer, but it has been shown to reduce implantations and live fetuses.

Palladone Novel Uses: Which Conditions Have a Clinical Trial Featuring Palladone?

33 active clinical trials are presently assessing the potential of Palladone to alleviate symptoms of Pain, Neuropathic Pain and Coughing.
Condition
Clinical Trials
Trial Phases
Neuropathic Pain
27 Actively Recruiting
Phase 1, Phase 2, Phase 3, Not Applicable, Phase 4
Coughing
4 Actively Recruiting
Phase 2, Phase 3
Pain
0 Actively Recruiting

Palladone Reviews: What are patients saying about Palladone?

5Patient Review
4/1/2010
Palladone for Chronic Pain
Pallodone was an amazing drug while it lasted. I have RSD and Palladone really helped me out. Does anyone know if it's still around?
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about palladone

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is palladone used for?

"PALLADONE can be used to manage pain in opioid-tolerant patients that is severe enough that it requires treatment with opioids every day and all day long. This is for cases where other treatment options have not been effective."

Answered by AI

Does hydromorphone come in capsules?

"Hydromorphone is used to relieve pain. The extended-release form of hydromorphone is used to relieve pain in opioid-tolerant patients severe enough to require around-the-clock pain relief for a long period of time."

Answered by AI

How do you give a hydromorphone Injection?

"The appropriate dosage for adults is 1-2 mg injected under the skin or into a muscle every 2-3 hours as needed. The doctor may adjust this dosage as necessary. The appropriate dosage for children must be determined by a doctor."

Answered by AI

Is Dilaudid used in UK?

"The psychoactive drug hydromorphone is prohibited in the United Kingdom by the 1971 Misuse of Drugs Act (MDA)."

Answered by AI

Clinical Trials for Palladone

Have you considered Palladone clinical trials? We made a collection of clinical trials featuring Palladone, we think they might fit your search criteria.
Have you considered Palladone clinical trials? We made a collection of clinical trials featuring Palladone, we think they might fit your search criteria.
Have you considered Palladone clinical trials? We made a collection of clinical trials featuring Palladone, we think they might fit your search criteria.
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