Zafirlukast

Asthma, Chronic Urticaria
Treatment
2 FDA approvals
20 Active Studies for Zafirlukast

What is Zafirlukast

ZafirlukastThe Generic name of this drug
Treatment SummaryZafirlukast is a medication used to treat asthma. It comes in the form of tablets and should be taken twice daily. Zafirlukast works by blocking the action of cysteinyl leukotrienes, which can cause airway constriction, mucus buildup and inflammation in the lungs. This drug is often used in combination with an inhaled steroid and/or a long-acting bronchodilator. Montelukast (Singulair) is another type of leukotriene receptor antagonist that must only be taken once a day.
Accolateis the brand name
image of different drug pills on a surface
Zafirlukast Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Accolate
Zafirlukast
1996
32

Approved as Treatment by the FDA

Zafirlukast, commonly known as Accolate, is approved by the FDA for 2 uses like Asthma and Asthma .
Asthma
Helps manage Asthma
Asthma
Helps manage Asthma

Effectiveness

How Zafirlukast Affects PatientsZafirlukast is a drug used to prevent and treat asthma. It works by blocking the actions of leukotrienes, which are compounds that can cause airway constriction in people with asthma. This drug has been shown to inhibit the contractile activity of three different leukotrienes in laboratory animals and humans, as well as reduce the swelling and influx of eosinophils caused by leukotrienes in animal lungs.
How Zafirlukast works in the bodyZafirlukast blocks the body's response to two types of leukotriene, which are involved in the process of asthma. Leukotrienes increase airway swelling, muscle tightening, and inflammation, which all contribute to the symptoms of asthma. By blocking these leukotrienes, Zafirlukast helps reduce the severity of asthma symptoms.

When to interrupt dosage

The measure of Zafirlukast is determined by the diagnosed state. The amount of dosage fluctuates in accordance with the technique of delivery (e.g. Tablet, film coated or Tablet) featured in the table beneath.
Condition
Dosage
Administration
Asthma
, 10.0 mg, 20.0 mg
Tablet, film coated, Tablet, film coated - Oral, , Oral, Tablet, coated, Tablet, coated - Oral, Tablet - Oral, Tablet
Chronic Urticaria
, 10.0 mg, 20.0 mg
Tablet, film coated, Tablet, film coated - Oral, , Oral, Tablet, coated, Tablet, coated - Oral, Tablet - Oral, Tablet

Warnings

Zafirlukast Contraindications
Condition
Risk Level
Notes
Cirrhosis
Do Not Combine
Liver Disease
Do Not Combine
There are 20 known major drug interactions with Zafirlukast.
Common Zafirlukast Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Zafirlukast.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Zafirlukast.
Albendazole
Major
The metabolism of Albendazole can be decreased when combined with Zafirlukast.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Zafirlukast.
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Zafirlukast.
Zafirlukast Toxicity & Overdose RiskPossible side effects of this drug include rash and stomach discomfort.
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Zafirlukast Novel Uses: Which Conditions Have a Clinical Trial Featuring Zafirlukast?

160 active studies are assessing the potential of Zafirlukast to ameliorate Chronic Urticaria.
Condition
Clinical Trials
Trial Phases
Chronic Urticaria
0 Actively Recruiting
Asthma
91 Actively Recruiting
Phase 1, Phase 4, Early Phase 1, Phase 2, Not Applicable, Phase 3

Zafirlukast Reviews: What are patients saying about Zafirlukast?

5Patient Review
4/3/2013
Zafirlukast for Chronic Obstructive Asthma
This drug is essential for my well-being. I have been taking it regularly for at least fifteen years, and if I forget to take it even for a day, I struggle to breathe.
5Patient Review
3/7/2013
Zafirlukast for Asthma Prevention
I made the switch to this medication from Singulair, and I'm really happy that I did. Not only has it been effective, but it's also much cheaper.
5Patient Review
5/31/2018
Zafirlukast for Asthma
Before I started this treatment, I was constantly wheezing and coughing. It didn't matter if I was sitting, standing, or lying down; I couldn't get a break. And forget about trying to sleep through the night! But since starting this medication, it's like those problems never existed.
5Patient Review
7/21/2018
Zafirlukast for Asthma
Accolate has been much more effective for me than Singulair, especially in terms of my asthma and sinus polyps. I have AERD, so this is a big deal for me.
4.7Patient Review
7/1/2013
Zafirlukast for Asthma
I completely agree that this treatment has been a miracle for me. I did have some short-term side effects, but they were nothing compared to how much it's helped me overall. I've been taking it since 2009 and it's allowed me to lead a normal life again. I hardly even notice my breathing now, so when there are problems I can identify them quickly and take care of them. Sleeping better at night has also helped reduce my fatigue during the day.
2.7Patient Review
3/29/2018
Zafirlukast for Chronic Obstructive Asthma
One of the unfortunate side-effects I experienced was hair loss.
1Patient Review
2/29/2012
Zafirlukast for Chronic Obstructive Asthma
Unfortunately, this medication caused my tongue to swell and I developed a rash. Since I have severe allergies, I can't take this medication anymore.
1Patient Review
5/24/2012
Zafirlukast for Asthma
I started taking this medication and immediately began to experience moderate itching. I don't think I'll continue using it.
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Patient Q&A Section about zafirlukast

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are side effects of zafirlukast?

"One may experience nausea, diarrhea, or stomach pain as a result of taking ibuprofen. A headache may also develop. Some people may experience cold symptoms such as a stuffy nose, sneezing, or a sore throat."

Answered by AI

What is the drug zafirlukast used for?

"Zafirlukast prevents asthma attacks from occurring. It cannot be used to relieve an attack that has already started. If you have an asthma attack that has already started, you should use an inhaled medicine that works quickly for relief."

Answered by AI

Why was zafirlukast discontinued?

"Zafirlukast, a leukotriene receptor antagonist, is being discontinued for commercial reasons. The closest available alternative is montelukast. Clinicians should be aware of this product being discontinued."

Answered by AI

Clinical Trials for Zafirlukast

Have you considered Zafirlukast clinical trials? We made a collection of clinical trials featuring Zafirlukast, we think they might fit your search criteria.Go to Trials
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Osteopathic Manipulative Treatment for Asthma

18 - 60
All Sexes
Mayfield Heights, OH
Asthma is a common respiratory condition that can be difficult to control despite the use of medications such as inhalers, oral steroids or even injectable medications. Osteopathic Manipulative Treatment (OMT) is a hands-on technique used to improve the chest structure and function and may help in improving breathing. Previous research showed that OMT in asthma patients, can improve the movement of the ribs and improve the "peak flow" which is the maximum rate at which a person can exhale air after taking a deep breath. However, no studies have evaluated the impact of OMT on lung inflammation. This single-site research study at University Hospitals aims to evaluate whether Osteopathic Manipulative Treatment (OMT) can reduce lung inflammation and improve breathing and lung function in adult patients with asthma. The lung function will be evaluated by Spirometry which is a test that measures how much air you can breathe in and out of your lungs, as well as how quickly and easily you can exhale air. The lung inflammation will be measured using a device that can detect how much you are breathing out Nitric Oxide which is a gas produced by inflamed cells in the lungs, this test is called: Fractional exhaled Nitric Oxide or FeNO. Approximately 100 participants will be enrolled.
Waitlist Available
Has No Placebo
Allergy Immunology AssociatesNancy Wasserbauer-Kingston, DO
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Inhaled Corticosteroids + Azithromycin for Asthma

13 - 75
All Sexes
Aurora, CO
While asthma therapy is becoming more individualized based on asthma phenotypes, more research is needed to tailor newer therapies to individuals. Inhaled corticosteroid (ICS) medications are the foundation of care for all individuals with persistent asthma. But ICS use is not without possible long term side effects. This study will compare two currently available approaches to reduce AEX in primary care patients: (1) use of inhaled corticosteroids (ICS) as part of rescue therapy, also known as MART (Maintenance And Reliever Therapy) or PARTICS (Patient Activated Reliever Trigger Inhaled Corticosteriods) therapy - either of these therapies will be called Rescue-Inhaled Corticosteroids or R-ICS pronounced "Ricks," and (2) use of azithromycin (AZ) as a preventive therapy. These treatments will be studied both individually and in combination.
Phase 4
Recruiting
DARTNet Institute (+12 Sites)Wilson D Pace, MD, FAAFP
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Pharmacy Support System for Asthma

Any Age
All Sexes
Ajax, Canada
The goal of this study is to assess the effect of an electronic asthma management system in pharmacies (eAMS-Pharm) on asthma control assessment, asthma medication adjustment, asthma action plan delivery, and prompting for specialist referral in severe asthma. The study assesses the differences on pharmacy processes (affecting both the pharmacy team and patients) and pharmacy-delivered care using an interrupted time-series analysis (six-months before vs. six-months after the introduction of eAMS-Pharm in study pharmacy sites). The eAMS-Pharm uses patient data (asthma control, asthma flare-up risk, and current medications) to provide clinical decision support to pharmacists, empowering them to bridge existing gaps between guideline-recommended asthma care and patient care received.
Waitlist Available
Has No Placebo
Medical Place Pharmacy (+2 Sites)
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Salbutamol for Athletic Performance

18 - 55
All Sexes
Vancouver, Canada
β2-Agonists, commonly used to treat asthma, have also been used by athletes to enhance performance, leading to their ban by the International Olympic Committee in 1972. Research has shown non-asthmatics receive no benefit from these drugs at therapeutic dosages; however, many elite athletes still use them, and asthmatic athletes often win more Olympic medals. In some non-asthmatics, β2-agonists may improve breathing limitations during high intensity exercise, which may improve performance. Therefore, we aim to examine if there is a select group of non-asthmatic individuals who experience breathing limitations that may receive benefit from β2-agonists.
Waitlist Available
Paid Trial
St. Paul's HospitalJordan A Guenette, PhD
Have you considered Zafirlukast clinical trials? We made a collection of clinical trials featuring Zafirlukast, we think they might fit your search criteria.Go to Trials
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PF-07275315 for Asthma

18 - 70
All Sexes
Mobile, AL
The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called PF-07275315) for the potential treatment of moderate-to-severe asthma. Asthma is a condition that makes it challenging to breathe, which negatively impacts the quality of life and functioning of people who are affected. This study is seeking participants who: * Are 18 to 70 years old * Have had moderate-to-severe asthma for at least 12 months that is not well controlled * Have been taking their regular maintenance treatment(s) for asthma over the last 12 months All participants will receive PF-07275315 or a placebo. A placebo does not have any medicine in it but looks just like the medicine being studied. PF-07275315 or placebo will be given as multiple shots in the clinic over the course of 12 weeks. We will compare the experiences of people receiving PF-07275315 to those of the people who do not. This will help us determine if PF-07275315 is safe and effective. Participants will be involved in this study for about 9.5 months. During this time, they will have 10 visits at the study clinic.
Phase 2
Recruiting
Velocity Clinical Research, Mobile (+10 Sites)Pfizer CT.gov Call CenterPfizer
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Corticosteroids for Asthma

18+
All Sexes
Hamilton, Canada
Most individuals with asthma can effectively manage their symptoms and maintain normal lung function using inhaled medications, unfortunately, there is a subset of asthma sufferers whose symptoms, lung function, and risk of asthma attacks remain unimproved despite conventional inhaled medications. There could be several reasons for this. One possibility is that inhaled medications fail to reach the intended areas within the lungs, due to structural abnormalities within the airways themselves. Much like road conditions or closures can impede the speed and efficiency of vehicle travel, factors such as airway narrowing or mucus blockages, which are common in asthma, can obstruct the passage of inhaled medications through the airways. Our team has now optimized advanced medical imaging techniques, including magnetic resonance imaging (MRI) and computed tomography (CT), required to investigate this. This study will use these imaging methods to visually assess and measure individual patients' airways and determine whether abnormal airway structures impact how well they respond to inhaled and orally delivered medications. We anticipate finding that abnormal airway structures make inhaled medications less effective, but that they do not affect the response to oral medications.
Phase 4
Recruiting
St. Joseph's Healthcare Hamilton (+1 Sites)
Have you considered Zafirlukast clinical trials? We made a collection of clinical trials featuring Zafirlukast, we think they might fit your search criteria.Go to Trials
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