Zafirlukast

Asthma, Chronic Urticaria

Treatment

2 FDA approvals

20 Active Studies for Zafirlukast

Treatment for

Asthma

What is Zafirlukast

ZafirlukastThe Generic name of this drug

Treatment SummaryZafirlukast is a medication used to treat asthma. It comes in the form of tablets and should be taken twice daily. Zafirlukast works by blocking the action of cysteinyl leukotrienes, which can cause airway constriction, mucus buildup and inflammation in the lungs. This drug is often used in combination with an inhaled steroid and/or a long-acting bronchodilator. Montelukast (Singulair) is another type of leukotriene receptor antagonist that must only be taken once a day.

Accolateis the brand name

image of different drug pills on a surface

Zafirlukast Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Accolate

Zafirlukast

1996

Approved as Treatment by the FDA

Zafirlukast, commonly known as Accolate, is approved by the FDA for 2 uses like Asthma and Asthma .

Asthma

Helps manage Asthma

Asthma

Helps manage Asthma

Effectiveness

How Zafirlukast Affects PatientsZafirlukast is a drug used to prevent and treat asthma. It works by blocking the actions of leukotrienes, which are compounds that can cause airway constriction in people with asthma. This drug has been shown to inhibit the contractile activity of three different leukotrienes in laboratory animals and humans, as well as reduce the swelling and influx of eosinophils caused by leukotrienes in animal lungs.

How Zafirlukast works in the bodyZafirlukast blocks the body's response to two types of leukotriene, which are involved in the process of asthma. Leukotrienes increase airway swelling, muscle tightening, and inflammation, which all contribute to the symptoms of asthma. By blocking these leukotrienes, Zafirlukast helps reduce the severity of asthma symptoms.

When to interrupt dosage

The measure of Zafirlukast is determined by the diagnosed state. The amount of dosage fluctuates in accordance with the technique of delivery (e.g. Tablet, film coated or Tablet) featured in the table beneath.

Condition

Dosage

Administration

Asthma

, 10.0 mg, 20.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral

Chronic Urticaria

, 10.0 mg, 20.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral

Warnings

Zafirlukast Contraindications

Condition

Risk Level

Notes

Cirrhosis

Do Not Combine

Liver Disease

Do Not Combine

There are 20 known major drug interactions with Zafirlukast.

Common Zafirlukast Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be decreased when combined with Zafirlukast.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be decreased when combined with Zafirlukast.

Albendazole

Major

The metabolism of Albendazole can be decreased when combined with Zafirlukast.

Alectinib

Major

The metabolism of Alectinib can be decreased when combined with Zafirlukast.

Amiodarone

Major

The metabolism of Amiodarone can be decreased when combined with Zafirlukast.

Zafirlukast Toxicity & Overdose RiskPossible side effects of this drug include rash and stomach discomfort.

image of a doctor in a lab doing drug, clinical research

Zafirlukast Novel Uses: Which Conditions Have a Clinical Trial Featuring Zafirlukast?

160 active studies are assessing the potential of Zafirlukast to ameliorate Chronic Urticaria.

Condition

Clinical Trials

Trial Phases

Chronic Urticaria

0 Actively Recruiting

Asthma

87 Actively Recruiting

Phase 4, Early Phase 1, Phase 2, Not Applicable, Phase 1, Phase 3

Zafirlukast Reviews: What are patients saying about Zafirlukast?

5Patient Review

4/3/2013

Zafirlukast for Chronic Obstructive Asthma

This drug is essential for my well-being. I have been taking it regularly for at least fifteen years, and if I forget to take it even for a day, I struggle to breathe.

5Patient Review

3/7/2013

Zafirlukast for Asthma Prevention

I made the switch to this medication from Singulair, and I'm really happy that I did. Not only has it been effective, but it's also much cheaper.

5Patient Review

5/31/2018

Zafirlukast for Asthma

Before I started this treatment, I was constantly wheezing and coughing. It didn't matter if I was sitting, standing, or lying down; I couldn't get a break. And forget about trying to sleep through the night! But since starting this medication, it's like those problems never existed.

5Patient Review

7/21/2018

Zafirlukast for Asthma

Accolate has been much more effective for me than Singulair, especially in terms of my asthma and sinus polyps. I have AERD, so this is a big deal for me.

4.7Patient Review

7/1/2013

Zafirlukast for Asthma

I completely agree that this treatment has been a miracle for me. I did have some short-term side effects, but they were nothing compared to how much it's helped me overall. I've been taking it since 2009 and it's allowed me to lead a normal life again. I hardly even notice my breathing now, so when there are problems I can identify them quickly and take care of them. Sleeping better at night has also helped reduce my fatigue during the day.

View All Reviews

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Patient Q&A Section about zafirlukast

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are side effects of zafirlukast?

"One may experience nausea, diarrhea, or stomach pain as a result of taking ibuprofen. A headache may also develop. Some people may experience cold symptoms such as a stuffy nose, sneezing, or a sore throat."

Answered by AI

What is the drug zafirlukast used for?

"Zafirlukast prevents asthma attacks from occurring. It cannot be used to relieve an attack that has already started. If you have an asthma attack that has already started, you should use an inhaled medicine that works quickly for relief."

Answered by AI

Why was zafirlukast discontinued?

"Zafirlukast, a leukotriene receptor antagonist, is being discontinued for commercial reasons. The closest available alternative is montelukast. Clinicians should be aware of this product being discontinued."

Answered by AI

Clinical Trials for Zafirlukast

Have you considered Zafirlukast clinical trials? We made a collection of clinical trials featuring Zafirlukast, we think they might fit your search criteria.

Have you considered Zafirlukast clinical trials? We made a collection of clinical trials featuring Zafirlukast, we think they might fit your search criteria.