What is Zafirlukast
ZafirlukastThe Generic name of this drug
Treatment SummaryZafirlukast is a medication used to treat asthma. It comes in the form of tablets and should be taken twice daily. Zafirlukast works by blocking the action of cysteinyl leukotrienes, which can cause airway constriction, mucus buildup and inflammation in the lungs. This drug is often used in combination with an inhaled steroid and/or a long-acting bronchodilator. Montelukast (Singulair) is another type of leukotriene receptor antagonist that must only be taken once a day.
Accolateis the brand name
Zafirlukast Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Accolate
Zafirlukast
1996
30
Approved as Treatment by the FDA
Zafirlukast, otherwise known as Accolate, is approved by the FDA for 1 uses such as Asthma .Asthma
Helps manage Asthma
Effectiveness
How Zafirlukast Affects PatientsZafirlukast is a drug used to prevent and treat asthma. It works by blocking the actions of leukotrienes, which are compounds that can cause airway constriction in people with asthma. This drug has been shown to inhibit the contractile activity of three different leukotrienes in laboratory animals and humans, as well as reduce the swelling and influx of eosinophils caused by leukotrienes in animal lungs.
How Zafirlukast works in the bodyZafirlukast blocks the body's response to two types of leukotriene, which are involved in the process of asthma. Leukotrienes increase airway swelling, muscle tightening, and inflammation, which all contribute to the symptoms of asthma. By blocking these leukotrienes, Zafirlukast helps reduce the severity of asthma symptoms.
When to interrupt dosage
The measure of Zafirlukast is determined by the diagnosed state. The amount of dosage fluctuates in accordance with the technique of delivery (e.g. Tablet, film coated or Tablet) featured in the table beneath.Condition
Dosage
Administration
Asthma
10.0 mg, 20.0 mg,
Tablet, film coated, Tablet, Tablet, coated - Oral, Tablet - Oral, , Oral, Tablet, coated, Tablet, film coated - Oral
Chronic Urticaria
10.0 mg, 20.0 mg,
Tablet, film coated, Tablet, Tablet, coated - Oral, Tablet - Oral, , Oral, Tablet, coated, Tablet, film coated - Oral
Warnings
Zafirlukast ContraindicationsCondition
Risk Level
Notes
Liver Disease
Do Not Combine
Cirrhosis
Do Not Combine
Common Zafirlukast Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Zafirlukast.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Zafirlukast.
Albendazole
Major
The metabolism of Albendazole can be decreased when combined with Zafirlukast.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Zafirlukast.
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Zafirlukast.
Zafirlukast Toxicity & Overdose RiskPossible side effects of this drug include rash and stomach discomfort.
Zafirlukast Novel Uses: Which Conditions Have a Clinical Trial Featuring Zafirlukast?
160 active studies are assessing the potential of Zafirlukast to ameliorate Chronic Urticaria.Condition
Clinical Trials
Trial Phases
Chronic Urticaria
13 Actively Recruiting
Early Phase 1, Phase 3, Phase 2, Phase 4
Asthma
148 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1
Zafirlukast Reviews: What are patients saying about Zafirlukast?
5Patient Review
4/3/2013 This drug is essential for my well-being. I have been taking it regularly for at least fifteen years, and if I forget to take it even for a day, I struggle to breathe.
5Patient Review
3/7/2013 I made the switch to this medication from Singulair, and I'm really happy that I did. Not only has it been effective, but it's also much cheaper.
5Patient Review
5/31/2018 Before I started this treatment, I was constantly wheezing and coughing. It didn't matter if I was sitting, standing, or lying down; I couldn't get a break. And forget about trying to sleep through the night! But since starting this medication, it's like those problems never existed.
5Patient Review
7/21/2018 Accolate has been much more effective for me than Singulair, especially in terms of my asthma and sinus polyps. I have AERD, so this is a big deal for me.
4.7Patient Review
7/1/2013 I completely agree that this treatment has been a miracle for me. I did have some short-term side effects, but they were nothing compared to how much it's helped me overall. I've been taking it since 2009 and it's allowed me to lead a normal life again. I hardly even notice my breathing now, so when there are problems I can identify them quickly and take care of them. Sleeping better at night has also helped reduce my fatigue during the day.
2.7Patient Review
3/29/2018 One of the unfortunate side-effects I experienced was hair loss.
1Patient Review
2/29/2012 Unfortunately, this medication caused my tongue to swell and I developed a rash. Since I have severe allergies, I can't take this medication anymore.
1Patient Review
5/24/2012 I started taking this medication and immediately began to experience moderate itching. I don't think I'll continue using it.
Patient Q&A Section about zafirlukast
What are side effects of zafirlukast?
"One may experience nausea, diarrhea, or stomach pain as a result of taking ibuprofen. A headache may also develop. Some people may experience cold symptoms such as a stuffy nose, sneezing, or a sore throat." - Anonymous Online Contributor
Unverified Answer
What is the drug zafirlukast used for?
"Zafirlukast prevents asthma attacks from occurring. It cannot be used to relieve an attack that has already started. If you have an asthma attack that has already started, you should use an inhaled medicine that works quickly for relief." - Anonymous Online Contributor
Unverified Answer
Why was zafirlukast discontinued?
"Zafirlukast, a leukotriene receptor antagonist, is being discontinued for commercial reasons. The closest available alternative is montelukast. Clinicians should be aware of this product being discontinued." - Anonymous Online Contributor
Unverified Answer
Clinical Trials for Zafirlukast
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