Indocin

Muscle Pain, Bursitis, Tendinopathy + 9 more
Treatment
3 Active Studies for Indocin

What is Indocin

IndomethacinThe Generic name of this drug
Treatment SummaryIndometacin is a non-steroidal anti-inflammatory drug (NSAID) used to reduce inflammation, pain, and fever. It is an indole-acetic acid derivative and works by blocking an enzyme called cyclooxygenase (COX), which is responsible for producing prostaglandins and thromboxanes. Indometacin was first approved for use by the FDA in 1965 and is commonly used to treat rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, acute shoulder pains, and acute gouty arthritis. It comes in oral capsules, rectal
Indomethacinis the brand name
image of different drug pills on a surface
Indocin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Indomethacin
Indomethacin
1984
241

Effectiveness

How Indocin Affects PatientsIndometacin is a type of painkiller and fever reducer used to treat inflammation in rheumatoid arthritis. It works by reducing pain, fever, swelling, and stiffness in the joints. It has been used to treat gouty arthritis, but it can also increase your risk of serious heart problems, like a stroke or heart attack. Additionally, it may lead to stomach bleeding, ulcers, or perforations. Studies have also suggested that indometacin may reduce blood flow to the brain, although the significance of this is not clear. It may also inhibit neuron activity in certain areas of the brain.
How Indocin works in the bodyIndometacin works by blocking two enzymes, cyclo-oxygenase and phospholipase A2. The enzymes normally convert substances in the body into prostaglandins, which help create inflammation. By blocking these enzymes, indometacin reduces inflammation and pain. It can also reduce fever by increasing blood flow to the skin and helping the body release heat. Indometacin is also used to close a patent ductus arteriosus, a birth defect that causes an open artery between the heart and lungs. It does this by preventing prostaglandins from keeping the artery open. Finally, indometacin

When to interrupt dosage

The prescribed amount of Indocin is contingent upon the identified illness, including Aquaporin 2, Arthritis, Gouty and Moderate to intense ankylosing spondylitis. The quantity of dosage is subject to the system of delivery (e.g. Capsule or Injection, powder, lyophilized, for solution) featured in the following table.
Condition
Dosage
Administration
Aquaporin 2
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Rheumatoid Arthritis
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Disease
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Moderate to severe ankylosing spondylitis
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Tendinopathy
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Bursitis
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Arthritis, Gouty
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Arthralgia
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Pain
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Body weight between 500 and 1750 g
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Muscle Pain
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Degenerative polyarthritis
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous

Warnings

Indocin Contraindications
Condition
Risk Level
Notes
Intracranial Hemorrhage
Do Not Combine
Congenital Heart Defect
Do Not Combine
aspirin
Do Not Combine
Asthma
Do Not Combine
Urticaria caused by NSAIDs
Do Not Combine
Hemorrhage
Do Not Combine
Congenital Heart Defect
Do Not Combine
Blood Coagulation Disorders
Do Not Combine
Gastrointestinal Hemorrhage
Do Not Combine
Hematochezia
Do Not Combine
Pulmonary Atresia
Do Not Combine
Pulse Frequency
Do Not Combine
Ductus Arteriosus, Patent
Do Not Combine
Enterocolitis, Necrotizing
Do Not Combine
proven or suspected untreated infection
Do Not Combine
Enterocolitis, Necrotizing
Do Not Combine
history of proctitis
Do Not Combine
Low Platelet Count
Do Not Combine
Coronary Artery Bypass Grafting
Do Not Combine
NSAID-Induced Asthma
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Indomethacin may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Indomethacin may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Indomethacin may interact with Pulse Frequency
There are 20 known major drug interactions with Indocin.
Common Indocin Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Indomethacin is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Indomethacin is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abetimus
Major
The risk or severity of adverse effects can be increased when Indomethacin is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Indomethacin is combined with Acteoside.
Altretamine
Major
The risk or severity of adverse effects can be increased when Indomethacin is combined with Altretamine.
Indocin Toxicity & Overdose RiskThe toxic dose of indomethacin for rats is 2.42mg/kg and 13mg/kg for mice. Signs of an overdose include nausea, vomiting, headache, dizziness, confusion, or fatigue. There have also been reports of tingling, numbness, or seizures. If an overdose occurs, the doctor may induce vomiting or pump the stomach to clear the drug. The patient should then be monitored for signs of stomach ulcers or bleeding, and antacids may be used.
image of a doctor in a lab doing drug, clinical research

Indocin Novel Uses: Which Conditions Have a Clinical Trial Featuring Indocin?

Currently, 24 active trials are being conducted to assess the potential of Indocin in relieving symptoms of Joint Pain, Degenerative polyarthritis and Muscular Aches.
Condition
Clinical Trials
Trial Phases
Arthritis, Gouty
0 Actively Recruiting
Muscle Pain
1 Actively Recruiting
Phase 4
Pain
0 Actively Recruiting
Arthralgia
0 Actively Recruiting
Body weight between 500 and 1750 g
0 Actively Recruiting
Bursitis
0 Actively Recruiting
Tendinopathy
0 Actively Recruiting
Aquaporin 2
2 Actively Recruiting
Phase 3, Not Applicable
Rheumatoid Arthritis
0 Actively Recruiting
Disease
0 Actively Recruiting
Moderate to severe ankylosing spondylitis
0 Actively Recruiting
Degenerative polyarthritis
0 Actively Recruiting

Indocin Reviews: What are patients saying about Indocin?

5Patient Review
3/14/2013
Indocin for Gout
Indocin was a total life-saver for me. I had debilitating hip pain that no one could figure out, until my MD did an exam and determined it might be joint related. He ordered an MRI, but in the meantime prescribed Indocin. Within two hours of taking the first dose, my pain completely subsided. I've been on the prescription regimen for two days now with zero side effects and zero pain.
5Patient Review
4/3/2013
Indocin for Gout
I'm currently taking this medication to help with the pain of my intracranial hypertension (or pseudotumor cerebri), however since starting this medication my headaches have actually gotten worse. Has anyone else had a similar experience? If so, I may stop taking this altogether.
5Patient Review
7/26/2014
Indocin for Rheumatoid Arthritis
I was prescribed this for an extremely painful ankle, which the doctor said was likely gout. He said it would help the pain quickly, but 12 hours later I'm still in agony. A shorter dose of a stronger pain medication would have been much better than this.
5Patient Review
2/21/2013
Indocin for Joint Damage causing Pain and Loss of Function
My blood pressure has increased since taking this medication, which I don't see listed as a side effect. Has anyone else experienced something similar?
4.3Patient Review
7/8/2016
Indocin for Gout
I had a severe outbreak of gout and my doctor prescribed Indocin. You must take this drug with food, or else you'll get dizzy and likely have diarrhea. I've only taken two pills so far but it has definitely reduced the pain and swelling. Another great thing for reducing swelling is Turmeric; it's a natural herb that works well with no side effects!
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about indocin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Indocin the same as ibuprofen?

"Indocin and ibuprofen are both effective at relieving pain in arthritis patients, with Indocin being the preferred option according to a study. It is unclear why patients preferred Indocin in the study."

Answered by AI

Is Indocin a narcotic?

"Indomethacin (Indocin) is not classified as a controlled substance."

Answered by AI

What are the side effects of Indocin?

"Side effects that may indicate a more serious issue are heart attack, stroke, skin changes, weight gain, swelling, shortness of breath, tachycardia, unusual bleeding, jaundice, stomach pain, pain with urination, bloody urine, blurry vision, and back pain. If you experience any of these, please seek medical attention immediately."

Answered by AI

What is Indocin used for?

"Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and swelling associated with arthritis or gout. It may also be used to relieve symptoms of mild to moderate acute pain."

Answered by AI

Clinical Trials for Indocin

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