Indocin

Muscle Pain, Bursitis, Tendinopathy + 9 more

Treatment

6 Active Studies for Indocin

What is Indocin

Indomethacin

The Generic name of this drug

Treatment Summary

Indometacin is a non-steroidal anti-inflammatory drug (NSAID) used to reduce inflammation, pain, and fever. It is an indole-acetic acid derivative and works by blocking an enzyme called cyclooxygenase (COX), which is responsible for producing prostaglandins and thromboxanes. Indometacin was first approved for use by the FDA in 1965 and is commonly used to treat rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, acute shoulder pains, and acute gouty arthritis. It comes in oral capsules, rectal

Indomethacin

is the brand name

image of different drug pills on a surface

Indocin Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Indomethacin

Indomethacin

1984

241

Effectiveness

How Indocin Affects Patients

Indometacin is a type of painkiller and fever reducer used to treat inflammation in rheumatoid arthritis. It works by reducing pain, fever, swelling, and stiffness in the joints. It has been used to treat gouty arthritis, but it can also increase your risk of serious heart problems, like a stroke or heart attack. Additionally, it may lead to stomach bleeding, ulcers, or perforations. Studies have also suggested that indometacin may reduce blood flow to the brain, although the significance of this is not clear. It may also inhibit neuron activity in certain areas of the brain.

How Indocin works in the body

Indometacin works by blocking two enzymes, cyclo-oxygenase and phospholipase A2. The enzymes normally convert substances in the body into prostaglandins, which help create inflammation. By blocking these enzymes, indometacin reduces inflammation and pain. It can also reduce fever by increasing blood flow to the skin and helping the body release heat. Indometacin is also used to close a patent ductus arteriosus, a birth defect that causes an open artery between the heart and lungs. It does this by preventing prostaglandins from keeping the artery open. Finally, indometacin

When to interrupt dosage

The prescribed amount of Indocin is contingent upon the identified illness, including Aquaporin 2, Arthritis, Gouty and Moderate to intense ankylosing spondylitis. The quantity of dosage is subject to the system of delivery (e.g. Capsule or Injection, powder, lyophilized, for solution) featured in the following table.

Condition

Dosage

Administration

Rheumatoid Arthritis

25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL

, Capsule - Oral, Capsule, Oral, Capsule, extended release - Oral, Capsule, extended release, Suppository, Suppository - Rectal, Rectal, Liquid; Powder, for solution - Ophthalmic, Liquid; Powder, for solution, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension, Suspension - Oral, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, for solution, Injection, powder, for solution - Intravenous

Disease

25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL

, Capsule - Oral, Capsule, Oral, Capsule, extended release - Oral, Capsule, extended release, Suppository, Suppository - Rectal, Rectal, Liquid; Powder, for solution - Ophthalmic, Liquid; Powder, for solution, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension, Suspension - Oral, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, for solution, Injection, powder, for solution - Intravenous

Aquaporin 2

25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL

, Capsule - Oral, Capsule, Oral, Capsule, extended release - Oral, Capsule, extended release, Suppository, Suppository - Rectal, Rectal, Liquid; Powder, for solution - Ophthalmic, Liquid; Powder, for solution, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension, Suspension - Oral, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, for solution, Injection, powder, for solution - Intravenous

Bursitis

25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL

, Capsule - Oral, Capsule, Oral, Capsule, extended release - Oral, Capsule, extended release, Suppository, Suppository - Rectal, Rectal, Liquid; Powder, for solution - Ophthalmic, Liquid; Powder, for solution, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension, Suspension - Oral, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, for solution, Injection, powder, for solution - Intravenous

Tendinopathy

25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL

, Capsule - Oral, Capsule, Oral, Capsule, extended release - Oral, Capsule, extended release, Suppository, Suppository - Rectal, Rectal, Liquid; Powder, for solution - Ophthalmic, Liquid; Powder, for solution, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension, Suspension - Oral, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, for solution, Injection, powder, for solution - Intravenous

Moderate to severe ankylosing spondylitis

25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL

, Capsule - Oral, Capsule, Oral, Capsule, extended release - Oral, Capsule, extended release, Suppository, Suppository - Rectal, Rectal, Liquid; Powder, for solution - Ophthalmic, Liquid; Powder, for solution, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension, Suspension - Oral, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, for solution, Injection, powder, for solution - Intravenous

Arthritis, Gouty

25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL

, Capsule - Oral, Capsule, Oral, Capsule, extended release - Oral, Capsule, extended release, Suppository, Suppository - Rectal, Rectal, Liquid; Powder, for solution - Ophthalmic, Liquid; Powder, for solution, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension, Suspension - Oral, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, for solution, Injection, powder, for solution - Intravenous

Arthralgia

25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL

, Capsule - Oral, Capsule, Oral, Capsule, extended release - Oral, Capsule, extended release, Suppository, Suppository - Rectal, Rectal, Liquid; Powder, for solution - Ophthalmic, Liquid; Powder, for solution, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension, Suspension - Oral, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, for solution, Injection, powder, for solution - Intravenous

Pain

25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL

, Capsule - Oral, Capsule, Oral, Capsule, extended release - Oral, Capsule, extended release, Suppository, Suppository - Rectal, Rectal, Liquid; Powder, for solution - Ophthalmic, Liquid; Powder, for solution, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension, Suspension - Oral, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, for solution, Injection, powder, for solution - Intravenous

Body weight between 500 and 1750 g

25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL

, Capsule - Oral, Capsule, Oral, Capsule, extended release - Oral, Capsule, extended release, Suppository, Suppository - Rectal, Rectal, Liquid; Powder, for solution - Ophthalmic, Liquid; Powder, for solution, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension, Suspension - Oral, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, for solution, Injection, powder, for solution - Intravenous

Muscle Pain

25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL

, Capsule - Oral, Capsule, Oral, Capsule, extended release - Oral, Capsule, extended release, Suppository, Suppository - Rectal, Rectal, Liquid; Powder, for solution - Ophthalmic, Liquid; Powder, for solution, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension, Suspension - Oral, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, for solution, Injection, powder, for solution - Intravenous

Degenerative polyarthritis

25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL

, Capsule - Oral, Capsule, Oral, Capsule, extended release - Oral, Capsule, extended release, Suppository, Suppository - Rectal, Rectal, Liquid; Powder, for solution - Ophthalmic, Liquid; Powder, for solution, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension, Suspension - Oral, Injection, powder, lyophilized, for solution - Intravenous, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, for solution, Injection, powder, for solution - Intravenous

Warnings

Indocin Contraindications

Condition

Risk Level

Notes

Intracranial Hemorrhage

Do Not Combine

Congenital Heart Defect

Do Not Combine

aspirin

Do Not Combine

Asthma

Do Not Combine

Urticaria caused by NSAIDs

Do Not Combine

Hemorrhage

Do Not Combine

Congenital Heart Defect

Do Not Combine

Blood Coagulation Disorders

Do Not Combine

Gastrointestinal Hemorrhage

Do Not Combine

Hematochezia

Do Not Combine

Pulmonary Atresia

Do Not Combine

Pulse Frequency

Do Not Combine

Ductus Arteriosus, Patent

Do Not Combine

Enterocolitis, Necrotizing

Do Not Combine

proven or suspected untreated infection

Do Not Combine

Enterocolitis, Necrotizing

Do Not Combine

history of proctitis

Do Not Combine

Low Platelet Count

Do Not Combine

Coronary Artery Bypass Grafting

Do Not Combine

NSAID-Induced Asthma

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Indomethacin may interact with Pulse Frequency

Severe Hypersensitivity Reactions

Do Not Combine

Indomethacin may interact with Pulse Frequency

Severe Hypersensitivity Reactions

Do Not Combine

Indomethacin may interact with Pulse Frequency

There are 20 known major drug interactions with Indocin.

Common Indocin Drug Interactions

Drug Name

Risk Level

Description

2-Methoxyethanol

Major

The risk or severity of adverse effects can be increased when Indomethacin is combined with 2-Methoxyethanol.

9-(N-methyl-L-isoleucine)-cyclosporin A

Major

The risk or severity of adverse effects can be increased when Indomethacin is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.

Abetimus

Major

The risk or severity of adverse effects can be increased when Indomethacin is combined with Abetimus.

Acteoside

Major

The risk or severity of adverse effects can be increased when Indomethacin is combined with Acteoside.

Altretamine

Major

The risk or severity of adverse effects can be increased when Indomethacin is combined with Altretamine.

Indocin Toxicity & Overdose Risk

The toxic dose of indomethacin for rats is 2.42mg/kg and 13mg/kg for mice. Signs of an overdose include nausea, vomiting, headache, dizziness, confusion, or fatigue. There have also been reports of tingling, numbness, or seizures. If an overdose occurs, the doctor may induce vomiting or pump the stomach to clear the drug. The patient should then be monitored for signs of stomach ulcers or bleeding, and antacids may be used.

image of a doctor in a lab doing drug, clinical research

Indocin Novel Uses: Which Conditions Have a Clinical Trial Featuring Indocin?

Currently, 24 active trials are being conducted to assess the potential of Indocin in relieving symptoms of Joint Pain, Degenerative polyarthritis and Muscular Aches.

Condition

Clinical Trials

Trial Phases

Arthritis, Gouty

0 Actively Recruiting

Muscle Pain

3 Actively Recruiting

Phase 4, Not Applicable, Phase 2

Pain

0 Actively Recruiting

Arthralgia

0 Actively Recruiting

Body weight between 500 and 1750 g

0 Actively Recruiting

Bursitis

0 Actively Recruiting

Tendinopathy

0 Actively Recruiting

Aquaporin 2

3 Actively Recruiting

Phase 3, Not Applicable, Phase 2

Rheumatoid Arthritis

0 Actively Recruiting

Disease

0 Actively Recruiting

Moderate to severe ankylosing spondylitis

0 Actively Recruiting

Degenerative polyarthritis

0 Actively Recruiting

Indocin Reviews: What are patients saying about Indocin?

5

Patient Review

3/14/2013

Indocin for Gout

Indocin was a total life-saver for me. I had debilitating hip pain that no one could figure out, until my MD did an exam and determined it might be joint related. He ordered an MRI, but in the meantime prescribed Indocin. Within two hours of taking the first dose, my pain completely subsided. I've been on the prescription regimen for two days now with zero side effects and zero pain.

5

Patient Review

4/3/2013

Indocin for Gout

I'm currently taking this medication to help with the pain of my intracranial hypertension (or pseudotumor cerebri), however since starting this medication my headaches have actually gotten worse. Has anyone else had a similar experience? If so, I may stop taking this altogether.

5

Patient Review

7/26/2014

Indocin for Rheumatoid Arthritis

I was prescribed this for an extremely painful ankle, which the doctor said was likely gout. He said it would help the pain quickly, but 12 hours later I'm still in agony. A shorter dose of a stronger pain medication would have been much better than this.

5

Patient Review

2/21/2013

Indocin for Joint Damage causing Pain and Loss of Function

My blood pressure has increased since taking this medication, which I don't see listed as a side effect. Has anyone else experienced something similar?

4.3

Patient Review

7/8/2016

Indocin for Gout

I had a severe outbreak of gout and my doctor prescribed Indocin. You must take this drug with food, or else you'll get dizzy and likely have diarrhea. I've only taken two pills so far but it has definitely reduced the pain and swelling. Another great thing for reducing swelling is Turmeric; it's a natural herb that works well with no side effects!

4.3

Patient Review

11/13/2012

Indocin for Gout

I found this treatment to be effective for my shoulder and knee pain.

4

Patient Review

5/16/2014

Indocin for Inflammation of the Tendon

I was prescribed Indocin for my chronic headaches, but it only marginally helped me over the course of six weeks. I also think that doctors should be more careful about prescribing this medication to patients with hypertension; my blood pressure skyrocketed while taking it and I ended up in the ER after passing out while using a snow blower. For now, I've decided to stop taking Indocin until my doctor can re-evaluate it.

3.3

Patient Review

10/6/2013

Indocin for Gout

I had cellulitis/phlebitis from an insect bite and Indocin did help reduce the swelling, but I couldn't continue use because of the diarrhea and stomach cramps it caused.

2.7

Patient Review

11/8/2012

Indocin for Inflammation of a Shoulder Joint

2.3

Patient Review

2/15/2014

Indocin for Painful Periods

This treatment quickly alleviated my coughing headaches, which was great since nothing else had worked. I didn't experience any negative side effects, either.

2

Patient Review

11/3/2013

Indocin for Inflammation of the Lining of a Joint

This treatment has helped me with my chronic gout, but this morning I took it without food and within an hour felt lightheaded and faint. This made me very anxious, but after doing some research online I found out that this is a common side effect of the drug. I also experienced diarrhea, but the alternative is that I can't walk, so I guess you have to pick your poison.

1.7

Patient Review

5/27/2015

Indocin for Gout

The doctor said I had gout in my foot, so he prescribed Indocin. After just four doses spread out over one day and evening, my foot is now very swollen and painful.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about indocin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Indocin the same as ibuprofen?

"Indocin and ibuprofen are both effective at relieving pain in arthritis patients, with Indocin being the preferred option according to a study. It is unclear why patients preferred Indocin in the study."

Answered by AI

Is Indocin a narcotic?

"Indomethacin (Indocin) is not classified as a controlled substance."

Answered by AI

What are the side effects of Indocin?

"Side effects that may indicate a more serious issue are heart attack, stroke, skin changes, weight gain, swelling, shortness of breath, tachycardia, unusual bleeding, jaundice, stomach pain, pain with urination, bloody urine, blurry vision, and back pain. If you experience any of these, please seek medical attention immediately."

Answered by AI

What is Indocin used for?

"Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and swelling associated with arthritis or gout. It may also be used to relieve symptoms of mild to moderate acute pain."

Answered by AI

Clinical Trials for Indocin

Image of McMaster Children's Hospital - Neonatal Intensive Care Unit in Hamilton, Canada.

Ibuprofen for Patent Ductus Arteriosus

< 18
All Sexes
Hamilton, Canada

Newborns born early are at risk for a serious health problem called patent ductus arteriosus (PDA). PDA is a passageway between heart and lung that can cause life-threatening complications such as bleeding in the brain or even death if it remains open and large. When closure of PDA is needed, doctors make every attempt to do it as soon as possible. Ibuprofen is the best drug to close the PDA, but it only works for 50% of small newborns. The investigators have shown before that small newborns handle ibuprofen differently and the amount of active ibuprofen that reaches their blood can be very unpredictable. Studies have shown if enough ibuprofen reaches the body, it can close the PDA. Therefore the investigators designed this study to see whether it is possible to give each newborn the right amount of ibuprofen that their body needs to close the PDA. The investigators will compare two ways to give ibuprofen in a small number of newborns: 1 - standard amount of ibuprofen to everyone, which is the usual care or 2 - ibuprofen doses that will be changed based on how much active ibuprofen has reached the body and how well the newborn's PDA is closing. The investigators will then compare the number of PDAs closed in each group and closely monitor any possible challenges for this new practice. By doing this project, the goals can be summarized as below: A. Primary goal: To determine if it is feasible to successfully run a larger study in the future. B. Secondary goals 1. To assess how well and how safely the personalized (MIPD) method works, using a tool called WAPPS-PDA to guide dosing. 2. To compare the effectiveness and safety of the personalized method with standard ibuprofen dosing. 3. To identify drug levels in the blood (Cmin, AUC0-24, AUC0-72) that are associated with complete, partial, or no response to treatment.

Phase 2
Recruiting

McMaster Children's Hospital - Neonatal Intensive Care Unit

Samira Samiee-Zafarghandy, MD, FRCPC

Image of Rutgers School of Dental Medicine in Newark, United States.

Temporo-masseteric Nerve Block for Postoperative Pain

18+
All Sexes
Newark, NJ

The proposed design is a triple-blind, placebo-controlled randomized prospective phase II trial to assess the feasibility of employing the Temporo-masseteric Nerve Block (TMNB) injection to decrease jaw muscle pain, overall pain, improve mouth opening and minimize pain medication consumption. 80 participants undergoing lower third molar removal under sedation will be enrolled. Those who develop significant jaw muscle pain on the following day will be randomized to receive either the TMNB injection or a placebo. Daily ecological momentary assessments (EMAs) will be collected reflecting elements of patient experience for all participants. On Day 8, participants return for an end-of-study evaluation and return their unused pain medications. Up to 40 participants who are randomized to receive TMNB/placebo will be recruited to participate in a qualitative interview regarding their experience.

Phase 2
Waitlist Available

Rutgers School of Dental Medicine

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