Probenecid And Colchicine

Postcommissurotomy Syndrome, Pericarditis, Postpericardiotomy Syndrome + 4 more

Treatment

4 FDA approvals

2 Active Studies for Probenecid And Colchicine

Treatment for

Postcommissurotomy Syndrome

What is Probenecid And Colchicine

Colchicine

The Generic name of this drug

Treatment Summary

Colchicine is a drug used to treat gout and Familial Mediterranean Fever (FMF). It was first approved by the FDA in 1961 and is derived from a plant called Colchicum autumnale, or “autumn crocus”. It works by reducing the inflammation and pain caused by the buildup of uric acid crystals in the joints. Colchicine is a commonly used and effective treatment for gout and FMF.

Probenecid and Colchicine

is the brand name

Probenecid And Colchicine Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Probenecid and Colchicine

Colchicine

1982

Approved as Treatment by the FDA

Colchicine, commonly known as Probenecid and Colchicine, is approved by the FDA for 4 uses which include prophylaxis of Gout Flares and Gout Flares .

prophylaxis of Gout Flares

Gout Flares

Familial Mediterranean Fever (FMF )

Familial Mediterranean Fever

Effectiveness

How Probenecid And Colchicine Affects Patients

Colchicine helps to reduce the pain of gout and can help to prevent flare-ups of Familial Mediterranean fever. However, people must be careful with this drug because the dose needs to be precise in order for it to be effective.

How Probenecid And Colchicine works in the body

Colchicine is thought to reduce inflammation by interfering with pathways that cause inflammation, like neutrophil adhesion and the RhoA/ROCK pathway. On a molecular level, colchicine works by blocking the activity of cells in the metaphase part of the cell cycle. It does this by binding to tubulin, forming complexes that bind to microtubules, preventing them from growing or depolymerizing them.

When to interrupt dosage

The portion of Probenecid And Colchicine is contingent upon the determined condition, such as Gout Flares, Pericarditis and Postcommissurotomy Syndrome. The measure of dosage also relies on the method of delivery featured in the table beneath.

Condition

Dosage

Administration

Familial Mediterranean Fever

0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg

, Tablet, Tablet - Oral, Oral, Tablet, film coated - Oral, Tablet, film coated, Capsule - Oral, Ointment, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Topical

prophylaxis of Gout Flares

0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg

Postcommissurotomy Syndrome

0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg

Pericarditis

0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg

Postpericardiotomy Syndrome

0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg

Behcet Syndrome

0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg

Gout Flares

0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg

Warnings

Probenecid And Colchicine has one contraindication. It should not be taken in situations where the conditions in the following table are present.

Probenecid And Colchicine Contraindications

Condition

Risk Level

Notes

Liver Disease

Do Not Combine

Liver Disease

Do Not Combine

There are 20 known major drug interactions with Probenecid And Colchicine.

Common Probenecid And Colchicine Drug Interactions

Drug Name

Risk Level

Description

Choline C 11

Major

The therapeutic efficacy of Choline C 11 can be decreased when used in combination with Colchicine.

Eliglustat

Major

The metabolism of Eliglustat can be decreased when combined with Colchicine.

Fentanyl

Major

The metabolism of Fentanyl can be decreased when combined with Colchicine.

Aclidinium

Minor

Colchicine may decrease the excretion rate of Aclidinium which could result in a higher serum level.

Acrivastine

Minor

Colchicine may decrease the excretion rate of Acrivastine which could result in a higher serum level.

Probenecid And Colchicine Toxicity & Overdose Risk

Colchicine is toxic if taken in large amounts. The lethal dose in mice is 5.87 mg/kg. Signs of an overdose can appear within 24 hours, such as abdominal pain, nausea, vomiting, diarrhea, and low blood cells. After 24 to 72 hours, more serious complications may occur, such as organ failure and respiratory depression, which can lead to death. If someone has overdosed on colchicine, stomach pumping and supportive treatment should be given and there is no antidote. Make sure to keep colchicine out of reach of children. Dialysis does not remove colchicine from the blood

Probenecid And Colchicine Novel Uses: Which Conditions Have a Clinical Trial Featuring Probenecid And Colchicine?

Presently, 3 active studies are investigating the potential of Probenecid And Colchicine to provide prophylaxis of Gout Flares, Behcet's Syndrome and Postpericardiotomy Syndrome.

Condition

Clinical Trials

Trial Phases

prophylaxis of Gout Flares

0 Actively Recruiting

Behcet Syndrome

0 Actively Recruiting

Gout Flares

1 Actively Recruiting

Phase 2

Pericarditis

2 Actively Recruiting

Phase 2, Phase 3

Familial Mediterranean Fever

0 Actively Recruiting

Postpericardiotomy Syndrome

0 Actively Recruiting

Postcommissurotomy Syndrome

0 Actively Recruiting

Probenecid And Colchicine Reviews: What are patients saying about Probenecid And Colchicine?

Patient Review

1/20/2010

Probenecid And Colchicine for Chronic Inflammation of the Joints due to Gout

Even though the stomach and diarrhea side effects are really tough to deal with, this medication completely got rid of my gout. So, when I have a bad attack again in the future, I'll definitely take it again.

Patient Review

1/11/2018

Probenecid And Colchicine for Chronic Inflammation of the Joints due to Gout

I had my first gout attack and this medication provided relief within 12 days. The only downside was that I experienced loose stools for a couple of days.

Patient Review

4/21/2009

Probenecid And Colchicine for Chronic Inflammation of the Joints due to Gout

Unfortunately, this medication caused me a lot of gastric distress. Additionally, I found myself unusually fatigued while taking it; this is not at all in line with my typical experience when taking medication. Pain levels also remain high.

4.3

Patient Review

2/15/2010

Probenecid And Colchicine for Chronic Inflammation of the Joints due to Gout

This medication has been passed down through generations of my family to treat gout flare-ups. It's incredibly effective, usually working within a day. The only downside is that if I take more than the prescribed amount, I get severe diarrhea.

4.3

Patient Review

12/4/2008

Probenecid And Colchicine for Chronic Inflammation of the Joints due to Gout

I unfortunately had an allergic reaction to this drug that resulted in itching, shortness of breath, and a rash.

3.3

Patient Review

12/5/2007

Probenecid And Colchicine for Chronic Inflammation of the Joints due to Gout

There's a potential for liver and kidney problems with this drug.

Patient Review

3/22/2021

Probenecid And Colchicine for Chronic Inflammation of the Joints due to Gout

Unfortunately, this medication caused me a lot of itching and discomfort.

Patient Review

3/15/2010

Probenecid And Colchicine for Osteoporosis

This treatment is effective.

2.3

Patient Review

5/11/2017

Probenecid And Colchicine for Chronic Inflammation of the Joints due to Gout

This was my first time using this prescription, and I had a pretty severe gout attack. The swelling was so bad I couldn't walk on my foot. Unfortunately, this medication did not help to reduce the swelling or pain at all, even after taking it for three days.

Patient Review

4/6/2012

Probenecid And Colchicine for Chronic Inflammation of the Joints due to Gout

Colchicine caused me severe vomiting and diarrhea. I would have rather dealt with the pain, which was horrendous. Allopurinol has done the job for me. I wouldn't recommend colchicine to anyone.

Patient Review

11/17/2009

Probenecid And Colchicine for Chronic Inflammation of the Joints due to Gout

This drug unfortunately caused a whole range of gastrointestinal issues like diarrhea, cramping and vomiting. I also got headaches.

1.7

Patient Review

9/3/2013

Probenecid And Colchicine for Chronic Inflammation of the Joints due to Gout

My doctor prescribed colchicine for my second flare up and it was terrible. I didn't experience any side effects, but it felt like the medication had no effect whatsoever on my pain.

1.7

Patient Review

7/8/2009

Probenecid And Colchicine for Chronic Inflammation of the Joints due to Gout

I've had gout for fifteen years now, and this medication has helped to reduce the frequency and severity of attacks.

1.7

Patient Review

10/13/2007

Probenecid And Colchicine for Chronic Inflammation of the Joints due to Gout

1.3

Patient Review

12/8/2007

Probenecid And Colchicine for Chronic Inflammation of the Joints due to Gout

The primary issue I experienced was a loss of short-term memory, and an increased likelihood of falling asleep. However, these symptoms went away after I stopped taking the medication and the gout attack subsided.

1.3

Patient Review

2/22/2009

Probenecid And Colchicine for Chronic Inflammation of the Joints due to Gout

I've had gout for over a decade and a half, but since switching to this medication from allopurinol, I've only had a handful of attacks. And none of them have been nearly as bad as they were before.

Patient Review

12/19/2011

Probenecid And Colchicine for Chronic Inflammation of the Joints due to Gout

The intensity of the vomiting and diarrhea this medication caused was really scary. I would have much rather dealt with the pain of gout than go through that again.

Patient Review

9/11/2008

Probenecid And Colchicine for Chronic Inflammation of the Joints due to Gout

This didn't work for me at all.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about probenecid and colchicine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are probenecid and colchicine the same thing?

"Probenecid is a uricosuric drug, meaning it helps remove uric acid from the body by increasing the rate at which the kidneys remove it. This decreases the amount of uric acid in the blood. Colchicine works by decreasing swelling and reducing the build-up of uric acid crystals that cause pain in the affected joint or joints."

Answered by AI

What are the side effects of probenecid colchicine?

"The text lists various medical symptoms, including headaches, dizziness, diarrhea, vomiting, nausea, stomach pain, gout attacks, and kidney stones."

Answered by AI

Can you take probenecid and colchicine together?

"The combination of probenecid and colchicine does not cure gout, it only helps to prevent attacks as long as the patient continues to take the medication. A prescription from a doctor is required to obtain this medication."

Answered by AI

What is colchicine probenecid used for?

"This medicine is a combination of probenecid and colchicine and is used to treat gout or gouty arthritis. The probenecid component helps to prevent gout attacks by removing excess uric acid from the body, while the colchicine also helps to prevent gout attacks."

Answered by AI