Probenecid And Colchicine

Postcommissurotomy Syndrome, Pericarditis, Postpericardiotomy Syndrome + 4 more
Treatment
4 FDA approvals
0 Active Studies for Probenecid And Colchicine

What is Probenecid And Colchicine

ColchicineThe Generic name of this drug
Treatment SummaryColchicine is a drug used to treat gout and Familial Mediterranean Fever (FMF). It was first approved by the FDA in 1961 and is derived from a plant called Colchicum autumnale, or “autumn crocus”. It works by reducing the inflammation and pain caused by the buildup of uric acid crystals in the joints. Colchicine is a commonly used and effective treatment for gout and FMF.
Probenecid and Colchicineis the brand name
Probenecid And Colchicine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Probenecid and Colchicine
Colchicine
1982
59

Approved as Treatment by the FDA

Colchicine, commonly known as Probenecid and Colchicine, is approved by the FDA for 4 uses which include Gout Flares and Familial Mediterranean Fever (FMF ) .
Gout Flares
Familial Mediterranean Fever (FMF )
prophylaxis of Gout Flares
Familial Mediterranean Fever

Effectiveness

How Probenecid And Colchicine Affects PatientsColchicine helps to reduce the pain of gout and can help to prevent flare-ups of Familial Mediterranean fever. However, people must be careful with this drug because the dose needs to be precise in order for it to be effective.
How Probenecid And Colchicine works in the bodyColchicine is thought to reduce inflammation by interfering with pathways that cause inflammation, like neutrophil adhesion and the RhoA/ROCK pathway. On a molecular level, colchicine works by blocking the activity of cells in the metaphase part of the cell cycle. It does this by binding to tubulin, forming complexes that bind to microtubules, preventing them from growing or depolymerizing them.

When to interrupt dosage

The portion of Probenecid And Colchicine is contingent upon the determined condition, such as Gout Flares, Pericarditis and Postcommissurotomy Syndrome. The measure of dosage also relies on the method of delivery featured in the table beneath.
Condition
Dosage
Administration
Familial Mediterranean Fever
0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release
prophylaxis of Gout Flares
0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release
Postcommissurotomy Syndrome
0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release
Pericarditis
0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release
Postpericardiotomy Syndrome
0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release
Behcet Syndrome
0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release
Gout Flares
0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release

Warnings

Probenecid And Colchicine has one contraindication. It should not be taken in situations where the conditions in the following table are present.Probenecid And Colchicine Contraindications
Condition
Risk Level
Notes
Liver Disease
Do Not Combine
Liver Disease
Do Not Combine
There are 20 known major drug interactions with Probenecid And Colchicine.
Common Probenecid And Colchicine Drug Interactions
Drug Name
Risk Level
Description
Choline C 11
Major
The therapeutic efficacy of Choline C 11 can be decreased when used in combination with Colchicine.
Eliglustat
Major
The metabolism of Eliglustat can be decreased when combined with Colchicine.
Fentanyl
Major
The metabolism of Fentanyl can be decreased when combined with Colchicine.
Aclidinium
Minor
Colchicine may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Minor
Colchicine may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Probenecid And Colchicine Toxicity & Overdose RiskColchicine is toxic if taken in large amounts. The lethal dose in mice is 5.87 mg/kg. Signs of an overdose can appear within 24 hours, such as abdominal pain, nausea, vomiting, diarrhea, and low blood cells. After 24 to 72 hours, more serious complications may occur, such as organ failure and respiratory depression, which can lead to death. If someone has overdosed on colchicine, stomach pumping and supportive treatment should be given and there is no antidote. Make sure to keep colchicine out of reach of children. Dialysis does not remove colchicine from the blood

Probenecid And Colchicine Novel Uses: Which Conditions Have a Clinical Trial Featuring Probenecid And Colchicine?

Presently, 3 active studies are investigating the potential of Probenecid And Colchicine to provide prophylaxis of Gout Flares, Behcet's Syndrome and Postpericardiotomy Syndrome.
Condition
Clinical Trials
Trial Phases
prophylaxis of Gout Flares
0 Actively Recruiting
Behcet Syndrome
0 Actively Recruiting
Gout Flares
0 Actively Recruiting
Pericarditis
0 Actively Recruiting
Familial Mediterranean Fever
0 Actively Recruiting
Postpericardiotomy Syndrome
0 Actively Recruiting
Postcommissurotomy Syndrome
0 Actively Recruiting

Probenecid And Colchicine Reviews: What are patients saying about Probenecid And Colchicine?

5Patient Review
1/20/2010
Probenecid And Colchicine for Chronic Inflammation of the Joints due to Gout
Even though the stomach and diarrhea side effects are really tough to deal with, this medication completely got rid of my gout. So, when I have a bad attack again in the future, I'll definitely take it again.
5Patient Review
1/11/2018
Probenecid And Colchicine for Chronic Inflammation of the Joints due to Gout
I had my first gout attack and this medication provided relief within 12 days. The only downside was that I experienced loose stools for a couple of days.
5Patient Review
4/21/2009
Probenecid And Colchicine for Chronic Inflammation of the Joints due to Gout
Unfortunately, this medication caused me a lot of gastric distress. Additionally, I found myself unusually fatigued while taking it; this is not at all in line with my typical experience when taking medication. Pain levels also remain high.
4.3Patient Review
2/15/2010
Probenecid And Colchicine for Chronic Inflammation of the Joints due to Gout
This medication has been passed down through generations of my family to treat gout flare-ups. It's incredibly effective, usually working within a day. The only downside is that if I take more than the prescribed amount, I get severe diarrhea.
4.3Patient Review
12/4/2008
Probenecid And Colchicine for Chronic Inflammation of the Joints due to Gout
I unfortunately had an allergic reaction to this drug that resulted in itching, shortness of breath, and a rash.
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about probenecid and colchicine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are probenecid and colchicine the same thing?

"Probenecid is a uricosuric drug, meaning it helps remove uric acid from the body by increasing the rate at which the kidneys remove it. This decreases the amount of uric acid in the blood. Colchicine works by decreasing swelling and reducing the build-up of uric acid crystals that cause pain in the affected joint or joints."

Answered by AI

What are the side effects of probenecid colchicine?

"The text lists various medical symptoms, including headaches, dizziness, diarrhea, vomiting, nausea, stomach pain, gout attacks, and kidney stones."

Answered by AI

Can you take probenecid and colchicine together?

"The combination of probenecid and colchicine does not cure gout, it only helps to prevent attacks as long as the patient continues to take the medication. A prescription from a doctor is required to obtain this medication."

Answered by AI

What is colchicine probenecid used for?

"This medicine is a combination of probenecid and colchicine and is used to treat gout or gouty arthritis. The probenecid component helps to prevent gout attacks by removing excess uric acid from the body, while the colchicine also helps to prevent gout attacks."

Answered by AI
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top