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What is Probenecid And Colchicine
ColchicineThe Generic name of this drug
Treatment SummaryColchicine is a drug used to treat gout and Familial Mediterranean Fever (FMF). It was first approved by the FDA in 1961 and is derived from a plant called Colchicum autumnale, or “autumn crocus”. It works by reducing the inflammation and pain caused by the buildup of uric acid crystals in the joints. Colchicine is a commonly used and effective treatment for gout and FMF.
Probenecid and Colchicineis the brand name
Probenecid And Colchicine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Probenecid and Colchicine
Colchicine
1982
59
Approved as Treatment by the FDA
Colchicine, commonly known as Probenecid and Colchicine, is approved by the FDA for 3 uses which include prophylaxis of Gout Flares and Gout Flares .prophylaxis of Gout Flares
Gout Flares
Familial Mediterranean Fever
Effectiveness
How Probenecid And Colchicine Affects PatientsColchicine helps to reduce the pain of gout and can help to prevent flare-ups of Familial Mediterranean fever. However, people must be careful with this drug because the dose needs to be precise in order for it to be effective.
How Probenecid And Colchicine works in the bodyColchicine is thought to reduce inflammation by interfering with pathways that cause inflammation, like neutrophil adhesion and the RhoA/ROCK pathway. On a molecular level, colchicine works by blocking the activity of cells in the metaphase part of the cell cycle. It does this by binding to tubulin, forming complexes that bind to microtubules, preventing them from growing or depolymerizing them.
When to interrupt dosage
The portion of Probenecid And Colchicine is contingent upon the determined condition, such as Gout Flares, Pericarditis and Postcommissurotomy Syndrome. The measure of dosage also relies on the method of delivery featured in the table beneath.Condition
Dosage
Administration
Postcommissurotomy Syndrome
0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release
prophylaxis of Gout Flares
0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release
Behcet's Syndrome
0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release
Gout Flares
0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release
Familial Mediterranean Fever
0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release
Pericarditis
0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release
Postpericardiotomy Syndrome
0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release
Warnings
Probenecid And Colchicine has one contraindication. It should not be taken in situations where the conditions in the following table are present.Probenecid And Colchicine ContraindicationsCondition
Risk Level
Notes
Liver Disease
Do Not Combine
Liver Disease
Do Not Combine
Common Probenecid And Colchicine Drug Interactions
Drug Name
Risk Level
Description
Choline C 11
Major
The therapeutic efficacy of Choline C 11 can be decreased when used in combination with Colchicine.
Eliglustat
Major
The metabolism of Eliglustat can be decreased when combined with Colchicine.
Fentanyl
Major
The metabolism of Fentanyl can be decreased when combined with Colchicine.
Aclidinium
Minor
Colchicine may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Minor
Colchicine may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Probenecid And Colchicine Toxicity & Overdose RiskColchicine is toxic if taken in large amounts. The lethal dose in mice is 5.87 mg/kg. Signs of an overdose can appear within 24 hours, such as abdominal pain, nausea, vomiting, diarrhea, and low blood cells. After 24 to 72 hours, more serious complications may occur, such as organ failure and respiratory depression, which can lead to death. If someone has overdosed on colchicine, stomach pumping and supportive treatment should be given and there is no antidote. Make sure to keep colchicine out of reach of children. Dialysis does not remove colchicine from the blood
Probenecid And Colchicine Novel Uses: Which Conditions Have a Clinical Trial Featuring Probenecid And Colchicine?
Presently, 3 active studies are investigating the potential of Probenecid And Colchicine to provide prophylaxis of Gout Flares, Behcet's Syndrome and Postpericardiotomy Syndrome.Condition
Clinical Trials
Trial Phases
Postcommissurotomy Syndrome
0 Actively Recruiting
Postpericardiotomy Syndrome
0 Actively Recruiting
Gout Flares
0 Actively Recruiting
Behcet's Syndrome
1 Actively Recruiting
Phase 2
Pericarditis
2 Actively Recruiting
Phase 2, Phase 3
Familial Mediterranean Fever
0 Actively Recruiting
prophylaxis of Gout Flares
0 Actively Recruiting
Probenecid And Colchicine Reviews: What are patients saying about Probenecid And Colchicine?
5Patient Review
1/20/2010 Even though the stomach and diarrhea side effects are really tough to deal with, this medication completely got rid of my gout. So, when I have a bad attack again in the future, I'll definitely take it again.
5Patient Review
1/11/2018 I had my first gout attack and this medication provided relief within 12 days. The only downside was that I experienced loose stools for a couple of days.
5Patient Review
4/21/2009 Unfortunately, this medication caused me a lot of gastric distress. Additionally, I found myself unusually fatigued while taking it; this is not at all in line with my typical experience when taking medication. Pain levels also remain high.
4.3Patient Review
2/15/2010 This medication has been passed down through generations of my family to treat gout flare-ups. It's incredibly effective, usually working within a day. The only downside is that if I take more than the prescribed amount, I get severe diarrhea.
4.3Patient Review
12/4/2008 I unfortunately had an allergic reaction to this drug that resulted in itching, shortness of breath, and a rash.
3.3Patient Review
12/5/2007 There's a potential for liver and kidney problems with this drug.
3Patient Review
3/22/2021 Unfortunately, this medication caused me a lot of itching and discomfort.
3Patient Review
3/15/2010 This treatment is effective.
2.3Patient Review
5/11/2017 This was my first time using this prescription, and I had a pretty severe gout attack. The swelling was so bad I couldn't walk on my foot. Unfortunately, this medication did not help to reduce the swelling or pain at all, even after taking it for three days.
2Patient Review
4/6/2012 Colchicine caused me severe vomiting and diarrhea. I would have rather dealt with the pain, which was horrendous. Allopurinol has done the job for me. I wouldn't recommend colchicine to anyone.
2Patient Review
11/17/2009 This drug unfortunately caused a whole range of gastrointestinal issues like diarrhea, cramping and vomiting. I also got headaches.
1.7Patient Review
9/3/2013 My doctor prescribed colchicine for my second flare up and it was terrible. I didn't experience any side effects, but it felt like the medication had no effect whatsoever on my pain.
1.7Patient Review
7/8/2009 I've had gout for fifteen years now, and this medication has helped to reduce the frequency and severity of attacks.
1.7Patient Review
10/13/20071.3Patient Review
12/8/2007 The primary issue I experienced was a loss of short-term memory, and an increased likelihood of falling asleep. However, these symptoms went away after I stopped taking the medication and the gout attack subsided.
1.3Patient Review
2/22/2009 I've had gout for over a decade and a half, but since switching to this medication from allopurinol, I've only had a handful of attacks. And none of them have been nearly as bad as they were before.
1Patient Review
12/19/2011 The intensity of the vomiting and diarrhea this medication caused was really scary. I would have much rather dealt with the pain of gout than go through that again.
1Patient Review
9/11/2008 This didn't work for me at all.
Patient Q&A Section about probenecid and colchicine
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Are probenecid and colchicine the same thing?
"Probenecid is a uricosuric drug, meaning it helps remove uric acid from the body by increasing the rate at which the kidneys remove it. This decreases the amount of uric acid in the blood. Colchicine works by decreasing swelling and reducing the build-up of uric acid crystals that cause pain in the affected joint or joints."
Answered by AI
Can you take probenecid and colchicine together?
"The combination of probenecid and colchicine does not cure gout, it only helps to prevent attacks as long as the patient continues to take the medication. A prescription from a doctor is required to obtain this medication."
Answered by AI
What is colchicine probenecid used for?
"This medicine is a combination of probenecid and colchicine and is used to treat gout or gouty arthritis. The probenecid component helps to prevent gout attacks by removing excess uric acid from the body, while the colchicine also helps to prevent gout attacks."
Answered by AI