Retrograde vs Antegrade Nephrostomy for Kidney Stones

Overseen By Amy Isidahomen

Age: Any Age

Sex: Any

Trial Phase: Academic

Sponsor: The University of Texas Health Science Center, Houston

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 3

Duration: 1 day

50 Participants Needed

Trial Summary

What is the purpose of this trial?

The purpose of this study is to compare relevant clinical outcomes in patients requiring percutaneous nephrostomy for urolithiasis treatment between those who undergo an antegrade approach versus a retrograde approach and to determine which clinical characteristics predict success of lithotomy with anterograde or retrograde percutaneous nephrostomy approaches.

Research Team

Nadeem N Dhanani, MD,MPH

Principal Investigator

The University of Texas Health Science Center, Houston

Eligibility Criteria

This trial is for individuals with large kidney stones (>10 mm) located in the renal pelvis or upper ureter, as confirmed by CT scans. It's not suitable for those who've had previous stone removal from the same kidney, have a current kidney infection, are pregnant, or have an abnormally shaped kidney like Horseshoe or Ectopic kidneys.

Inclusion Criteria

I have kidney stones larger than 10 mm in my renal pelvis or ureter.

Exclusion Criteria

I have an abnormal kidney shape or position.

I am suspected to have a kidney infection.

Pregnancy

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo percutaneous nephrostomy for urolithiasis treatment using either retrograde or antegrade approach

1 day

1 visit (in-person)

Follow-up

Participants are monitored for stone-free status and normal laboratory values

6-12 weeks

2 visits (in-person)

Treatment Details

Interventions

• Antegrade Nephrostomy
• Retrograde Nephrostomy

Trial Overview The study compares two techniques of creating a channel to reach and remove kidney stones: one where access is made going backwards (retrograde) into the urinary system versus another where access is made going forwards (antegrade). The goal is to see which method leads to better outcomes.

Participant Groups

Group I: Treatment (retrograde nephrostomy) Experimental Treatment 1 Intervention

Group II: Control Group ( antegrade nephrostomy) Active Control 1 Intervention

Who Is Running the Clinical Trial?

The University of Texas Health Science Center, Houston

Lead Sponsor

Trials

974

Recruited

361,000+