Your session is about to expire
What is Horizant
Gabapentin enacarbilThe Generic name of this drug
Treatment SummaryHorizant is a drug used to treat Restless Legs Syndrome (RLS) and postherpetic neuralgia (PHN) in adults. It is the brand name for the medication gabapentin enacarbil, which is a prodrug of gabapentin.
Horizantis the brand name
Horizant Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Horizant
Gabapentin enacarbil
2011
6
Approved as Treatment by the FDA
Gabapentin enacarbil, commonly known as Horizant, is approved by the FDA for 2 uses like Postherpetic Neuralgia and Restless Legs Syndrome (RLS) .Postherpetic Neuralgia
Helps manage Postherpetic Neuralgia
Restless Legs Syndrome (RLS)
Helps manage Restless Legs Syndrome (RLS)
Effectiveness
How Horizant Affects PatientsGabapentin enacarbil is a form of gabapentin, and therefore produces the same effects in the body. Specifically, it can help to prevent pain from nerve damage (allodynia and hyperalgesia) associated with postherpetic neuralgia.
How Horizant works in the bodyWe don't know exactly how gabapentin works, but it is thought to reduce nerve pain by activating certain receptors in the spine.
When to interrupt dosage
The proposed dosage of Horizant is contingent upon the determined condition. The quantity of dosage is subject to the technique of delivery (e.g. Oral or Tablet, extended release) recorded in the table beneath.Condition
Dosage
Administration
Postherpetic Neuralgia
300.0 mg, , 600.0 mg
Oral, , Tablet, extended release, Tablet, extended release - Oral
Restless Legs Syndrome (RLS)
300.0 mg, , 600.0 mg
Oral, , Tablet, extended release, Tablet, extended release - Oral
Warnings
Horizant ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Common Horizant Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Gabapentin enacarbil may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ethanol
Major
Gabapentin enacarbil may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Gabapentin enacarbil is combined with Oliceridine.
Thalidomide
Major
Gabapentin enacarbil may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Acrivastine
Minor
Gabapentin enacarbil may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Horizant Toxicity & Overdose RiskThe most common side effects of this drug are headaches, dizziness, and feeling sleepy.
Horizant Novel Uses: Which Conditions Have a Clinical Trial Featuring Horizant?
One active trial is currently exploring the potential of Horizant in relieving Postherpetic Neuralgia.Condition
Clinical Trials
Trial Phases
Postherpetic Neuralgia
0 Actively Recruiting
Restless Legs Syndrome (RLS)
1 Actively Recruiting
Not Applicable
Horizant Reviews: What are patients saying about Horizant?
5Patient Review
8/31/2017 I'm amazed that it took this long to find a medication that would alleviate my restless leg syndrome. Now, I only need to take one tablet of Horizant at dinner and I feel so much better. I no longer have the constant urge to move around at night and can finally enjoy a good night's sleep.
5Patient Review
9/23/2015 I've found that the best results happen when I take this medication 4-5 hours before bedtime. Otherwise, I wake up feeling groggy and disoriented. Additionally, taking more than two pills can result in Restless Leg Syndrome, so it's important to be mindful of dosage.
5Patient Review
1/12/2018 I was initially worried after reading other reviews about the possibility of being in a "stupor" or not getting pain relief. However, I followed the instructions to take it at 5PM with food, and I'm glad I did! My RLS pain is now controlled.
5Patient Review
2/18/2019 This drug has been amazing for treating my RLS. I've had it since I was a child, and it's only gotten worse as I've gotten older. Horizant has been a godsend.
5Patient Review
4/20/2018 I had no idea that I had RLS for years, because my doctors misdiagnosed it as arthritis. But after taking Horizant, I finally found some relief.
5Patient Review
6/24/2017 Despite no relief from my pain, I appreciate how this pill helps me manage my condition.
4.7Patient Review
8/19/2018 This medication makes it much easier to wake up in the morning without feeling groggy. I've only been taking it for a week and most of my pain has gone away.
4Patient Review
2/19/2020 I've been taking this treatment for four months to help with the pain medication I'm already on, and it's been working great. No side effects that I've noticed, just make sure you take it with food.
4Patient Review
7/5/2013 I got a sample bottle of this medication from my doctor, and it was such a relief! I felt a little bit dizzy in the morning if I took it after 5pm, but I slept so soundly. The Requip was doing a good job, but this is a lot better. I have had RLS for 8 years and to finally get a good night's sleep is a blessing.
2.7Patient Review
2/9/2015 Unfortunately, this medication made my vision double and blurry.
1Patient Review
12/7/2016 I really love this treatment! It's helped me so much.
Patient Q&A Section about horizant
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of the drug Horizant?
"The text lists symptoms which may include feeling tired, uncoordinated, or having blurred vision."
Answered by AI
Is Horizant and gabapentin the same?
"It's not clear how Horizant (gabapentin enacarbil) treats restless legs syndrome or nerve pain caused by shingles, but it may affect certain chemicals and nerves in the body to produce pain relief."
Answered by AI