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What is Scopolamine
Methscopolamine bromideThe Generic name of this drug
Treatment SummaryScopolamine is a medication used to reduce nausea and vomiting caused by motion sickness or surgery. It works by blocking the activity of a neurotransmitter called acetylcholine in the body. Scopolamine was first developed in 1959 and was approved by the FDA in 1979. It is available as both a pill and a patch applied to the skin, called Scopoderm TTS®. Scopolamine can cause serious side effects, so it is important to follow your doctor’s instructions when taking this medication.
Pamineis the brand name
Scopolamine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Pamine
Methscopolamine bromide
1953
17
Approved as Treatment by the FDA
Methscopolamine bromide, also known as Pamine, is approved by the FDA for 1 uses like Peptic Ulcer .Peptic Ulcer
Effectiveness
How Scopolamine Affects PatientsScopolamine is a medication used to reduce nerve activity in the body, help with motion sickness, and treat digestive problems. It is typically released as a patch over three days and can be detected in the body for up to 108 hours. It should be used with caution in people with glaucoma, women with severe preeclampsia, and those with gastrointestinal or urinary disorders. Scopolamine may cause blurred vision, skin burns during an MRI, and interfere with gastric secretion testing. It can also lead to dependence and withdrawal symptoms when it is stopped.
How Scopolamine works in the bodyAcetylcholine is a neurotransmitter that signals through different types of receptors. It helps control muscle contractions, glandular secretions, and heart rate. Scopolamine is a drug that blocks acetylcholine from binding to its receptors. This has therapeutic effects such as reducing nausea and vomiting, but it can also have adverse effects. Scopolamine also affects the nervous system by decreasing the release of certain neurotransmitters, which can help with stress, depression, and other neurological conditions. It is unclear how scopolamine helps with nausea and vomiting specifically, but it likely has to do with its anticholinergic effect
When to interrupt dosage
The prescribed dose of Scopolamine is contingent upon the acknowledged condition, including Preanesthetic Medication, Nausea and Motion Sickness. The measure of dosage relies on the method of delivery (e.g. Oral or Elixir) specified in the table beneath.Condition
Dosage
Administration
Peptic Ulcer
, 2.5 mg, 5.0 mg
, Oral, Tablet, Tablet - Oral
Warnings
Scopolamine ContraindicationsCondition
Risk Level
Notes
Myasthenia Gravis
Do Not Combine
Paralytic Ileus
Do Not Combine
Ulcerative Colitis
Do Not Combine
Ulcerative Colitis
Do Not Combine
Arterial Occlusive Diseases
Do Not Combine
Uterine Inertia
Do Not Combine
Uropathy Obstructive
Do Not Combine
Uterine Inertia
Do Not Combine
Hemorrhage
Do Not Combine
Open-angle glaucoma
Do Not Combine
Common Scopolamine Drug Interactions
Drug Name
Risk Level
Description
Aclidinium
Major
The risk or severity of adverse effects can be increased when Methscopolamine bromide is combined with Aclidinium.
Cimetropium
Major
The risk or severity of adverse effects can be increased when Methscopolamine bromide is combined with Cimetropium.
Eluxadoline
Major
The risk or severity of constipation can be increased when Methscopolamine bromide is combined with Eluxadoline.
Glycopyrronium
Major
The risk or severity of adverse effects can be increased when Methscopolamine bromide is combined with Glycopyrronium.
Ipratropium
Major
The risk or severity of adverse effects can be increased when Methscopolamine bromide is combined with Ipratropium.
Scopolamine Toxicity & Overdose RiskAn overdose on scopolamine may cause drowsiness, confusion, agitation, hallucinations, convulsions, dry skin, dry mouth, decreased bowel sounds, difficulty urinating, rapid heart rate, high blood pressure, and abnormal heart rhythms. Symptoms of overdose are similar to those of withdrawal, but withdrawal symptoms such as headache, nausea, abdominal cramps, and sweating can help distinguish between them. Treating an overdose usually involves removing any transdermal patch systems, maintaining an airway, giving oxygen, establishing intravenous access, and continuous monitoring. If the patient has swallowed one or more patch systems, they may need to be removed
Scopolamine Novel Uses: Which Conditions Have a Clinical Trial Featuring Scopolamine?
At present, there are four active trials investigating the potential of Scopolamine in relieving Motion Sickness, Nausea and Airsickness.Condition
Clinical Trials
Trial Phases
Peptic Ulcer
2 Actively Recruiting
Not Applicable, Phase 4
Scopolamine Reviews: What are patients saying about Scopolamine?
5Patient Review
9/3/2013Patient Q&A Section about scopolamine
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is scopolamine a sedative?
"Intranasal scopolamine could be a better option than promethazine for reducing space motion sickness, because it doesn't cause drowsiness and doesn't affect cognitive performance."
Answered by AI
Is scopolamine over the counter?
"Scopolamine (Transderm Scop) is only available with a prescription from a healthcare provider, because it can cause serious side effects if you have certain medical conditions or take other medications."
Answered by AI
What is the side effect of scopolamine?
"You may experience dry mouth, drowsiness, dizziness, decreased sweating, constipation, and mild itching/redness on the application site. If you experience any of these effects, speak to your doctor or pharmacist."
Answered by AI
What does the drug scopolamine do?
"The scopolamine transdermal patch is a medication used to prevent nausea and vomiting. It is typically used after anesthesia, narcotic pain medication, or surgery. It can also be used to prevent nausea and vomiting caused by motion sickness. The patch is worn for up to three days."
Answered by AI