What is Antivert
MeclizineThe Generic name of this drug
Treatment SummaryMeclizine is a medication that helps to reduce the symptoms of motion sickness and vertigo. It works by blocking histamine in the brain, and can also have calming effects on the central nervous system. Meclizine is generally prescribed to be taken orally as tablets, and is available under the brand name Antivert in the U.S.
Meclizine Hydrochlorideis the brand name
Antivert Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Meclizine Hydrochloride
Meclizine
1981
193
Approved as Treatment by the FDA
Meclizine, commonly known as Meclizine Hydrochloride, is approved by the FDA for 3 uses including Disease and Vertigo .Disease
Helps manage diseases affecting vestibular system
Vertigo
Helps manage Vertigo
Airsickness
Effectiveness
How Antivert Affects PatientsMeclizine is used to reduce nausea, vomiting, or dizziness, particularly caused by motion sickness or problems with the vestibular system. It usually starts working within an hour and can last up to 24 hours. Meclizine can cause drowsiness due to its effects on the brain.
How Antivert works in the bodyVomiting is a reflex that is regulated by an area in the brain called the CTZ. This area sends signals to another area called the vomiting center. Different receptors, such as histamine, serotonin, and dopamine, are found in the brainstem and can trigger a vomiting response. Meclizine works by blocking the histamine receptors in the vestibular nuclei and the nucleus of the solitary tract, thus preventing signals from reaching the vomiting center. Meclizine may also reduce stimulation of the area that controls balance and coordination.
When to interrupt dosage
The advised dose of Antivert is contingent upon the determined affliction, such as Disease, Vertigo and Airsickness. The amount of dosage is dependent on the method of delivery outlined in the table below.Condition
Dosage
Administration
Airsickness
, 25.0 mg, 12.5 mg, 25.0 mg/mL, 50.0 mg, 0.25 mg, 30.0 mg
, Oral, Tablet, chewable, Tablet - Oral, Tablet, Tablet, chewable - Oral, Tablet, multilayer, extended release - Oral, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Kit - Oral, Liquid, Tablet, multilayer, extended release, Tablet, film coated, Tablet, film coated - Oral, Film, soluble, Oral; Topical, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Film, soluble - Oral, Liquid - Oral, Kit
Disease
, 25.0 mg, 12.5 mg, 25.0 mg/mL, 50.0 mg, 0.25 mg, 30.0 mg
, Oral, Tablet, chewable, Tablet - Oral, Tablet, Tablet, chewable - Oral, Tablet, multilayer, extended release - Oral, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Kit - Oral, Liquid, Tablet, multilayer, extended release, Tablet, film coated, Tablet, film coated - Oral, Film, soluble, Oral; Topical, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Film, soluble - Oral, Liquid - Oral, Kit
Vertigo
, 25.0 mg, 12.5 mg, 25.0 mg/mL, 50.0 mg, 0.25 mg, 30.0 mg
, Oral, Tablet, chewable, Tablet - Oral, Tablet, Tablet, chewable - Oral, Tablet, multilayer, extended release - Oral, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Kit - Oral, Liquid, Tablet, multilayer, extended release, Tablet, film coated, Tablet, film coated - Oral, Film, soluble, Oral; Topical, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Film, soluble - Oral, Liquid - Oral, Kit
Warnings
Antivert ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Meclizine may interact with Toxoplasma Infections
Common Antivert Drug Interactions
Drug Name
Risk Level
Description
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Meclizine.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Meclizine.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Meclizine.
Azelastine
Major
Meclizine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Clomipramine
Major
The metabolism of Clomipramine can be decreased when combined with Meclizine.
Antivert Toxicity & Overdose RiskThe lowest toxic dose of meclizine in mice has been found to be 1600mg/kg when administered orally and 625mg/kg when administered intraperitoneally. In rats, the lowest toxic dose is 800mg/kg when administered orally. Symptoms of overdose may include extreme drowsiness, coma, seizures, and low blood pressure (especially in the elderly). In children, overdose may produce anticholinergic effects and hallucinations. Treatment for meclizine overdose includes supportive care and, if taken recently, inducing vomiting or using a gastric lavage to limit further absorption. Physostigmine may be used to counteract
Antivert Novel Uses: Which Conditions Have a Clinical Trial Featuring Antivert?
10 active trials are presently investigating the potential of Antivert to mitigate Disease, Airsickness and Vertigo symptoms.Condition
Clinical Trials
Trial Phases
Vertigo
6 Actively Recruiting
Phase 1, Phase 2, Not Applicable
Disease
1 Actively Recruiting
Early Phase 1
Airsickness
5 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Antivert Reviews: What are patients saying about Antivert?
5Patient Review
10/26/2013 I unfortunately did not experience any relief from my vertigo after using this medication.
5Patient Review
2/3/20124.7Patient Review
3/3/20124.7Patient Review
4/26/20124.3Patient Review
2/3/2016 This medication always makes me sleepy, but it's really effective when I'm in a lot of pain and can't walk because of dizziness. I've been using it for 15 years, only as needed.
4.3Patient Review
4/30/2016 I've had vertigo three times now and this medication always seems to help. However, I do get very drowsy after taking it.
4Patient Review
3/31/2013 I have vertigo that comes and goes, and I'm not sure if this drug helps with that or not. However, I do know that it makes me feel incredibly sleepy to the point where I can't function.
4Patient Review
3/29/2013 I have had this problem for 40 years and, unfortunately, this treatment did not help.
3Patient Review
1/25/2016 These pills work well to keep spinning-induced nausea at bay, but they make me very drowsy.
2.3Patient Review
12/13/20112.3Patient Review
7/26/2012 This treatment helps me when I'm feeling vertigo, though it's not a perfect solution.
2Patient Review
11/30/20111.7Patient Review
11/27/2015 Though it does help with vertigo, this medication unfortunately also very significantly impairs my energy levels and motivation.
1Patient Review
10/28/2014 Meclizine did nothing to help with my dizzy spells. If anything, they got worse when I was taking the medication. I only found relief after quitting the meds and flushing them out of my system.
Patient Q&A Section about antivert
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Antivert sold over the counter?
"Antivert and Bonine are both available to purchase, however Antivert is only obtainable through a prescription whereas Bonine can be bought over-the-counter. They have similar side effects such as blurred vision, dry mouth and drowsiness, however Antivert also has constipation, dizziness, headache, vomiting and tiredness as additional side effects."
Answered by AI
How long does it take for Antivert to work for vertigo?
"The bottom line is that meclizine can be used to treat vertigo or nausea and vomiting caused by motion sickness. However, it takes about an hour to start working and may cause drowsiness, although it is less likely to cause drowsiness than some other antihistamines."
Answered by AI
What does Antivert do for vertigo?
"Antivert is a medication used to prevent or treat nausea, vomiting, and dizziness caused by motion sickness. It may also be used to reduce lightheadedness, dizziness, and loss of balance (vertigo) caused by diseases that affect the inner ear."
Answered by AI
What is the medication Antivert used for?
"Meclizine is an antihistamine that is used to prevent and treat nausea, vomiting, and dizziness caused by motion sickness. It may also be used to reduce dizziness and loss of balance (vertigo) caused by inner ear problems."
Answered by AI