Xulane

Transdermal contraception therapy, Polycystic Ovarian Syndrome
Treatment
7 Active Studies for Xulane

What is Xulane

NorelgestrominThe Generic name of this drug
Treatment SummaryNorelgestromin is a medication used to prevent pregnancy. It is the active hormone in the ORTHO EVRA patch, which is applied to the skin to release the medication over time.
Ortho Evrais the brand name
image of different drug pills on a surface
Xulane Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ortho Evra
Norelgestromin
2001
7

Effectiveness

How Xulane Affects PatientsNorelgestromin is used as a form of birth control and in menopausal hormonal therapy. To work properly, it needs to be applied to the skin or taken with ethinyl estradiol in the form of a vaginal ring. Norelgestromin works by stopping gonadotropins, which inhibits ovulation.
How Xulane works in the bodyNorelgestromin prevents pregnancy by blocking the conversion of hormones in the body that create estrogen. It also binds to both estrogen and progesterone receptors, which helps to stop follicular development, make the uterus less likely to accept an egg, thicken cervical mucus and slow sperm from swimming into the uterus.

When to interrupt dosage

The degree of Xulane is contingent upon the specified disorder. The amount of dosage is contingent upon the technique of administration detailed in the table below.
Condition
Dosage
Administration
Polycystic Ovarian Syndrome
, 0.015 mg/hour, 6.0 mg, 6.0 mg/[USP'U], 0.06 mg/hour, 0.02 mg/hour
, Patch, extended release, Transdermal, Patch, extended release - Transdermal, Patch - Transdermal, Patch
Transdermal contraception therapy
, 0.015 mg/hour, 6.0 mg, 6.0 mg/[USP'U], 0.06 mg/hour, 0.02 mg/hour
, Patch, extended release, Transdermal, Patch, extended release - Transdermal, Patch - Transdermal, Patch

Warnings

Xulane has fourteen prohibitive contraindications, and it should not be taken for any of the conditions given in the following table.Xulane Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Hereditary Angioedema Type III
Do Not Combine
Liver Neoplasms
Do Not Combine
estrogen-sensitive cancer
Do Not Combine
Pulse Frequency
Do Not Combine
Hypersensitivity
Do Not Combine
Breast Cancer
Do Not Combine
Hypersensitivity
Do Not Combine
Venous Thrombosis
Do Not Combine
Pulse Frequency
Do Not Combine
Uterine hemorrhage
Do Not Combine
Non-alcoholic Fatty Liver Disease
Do Not Combine
high risk of arterial thrombotic disease
Do Not Combine
Liver diseases
Do Not Combine
There are 20 known major drug interactions with Xulane.
Common Xulane Drug Interactions
Drug Name
Risk Level
Description
Tranexamic acid
Major
Norelgestromin may increase the thrombogenic activities of Tranexamic acid.
Acetohexamide
Minor
The therapeutic efficacy of Acetohexamide can be decreased when used in combination with Norelgestromin.
Carbutamide
Minor
The therapeutic efficacy of Carbutamide can be decreased when used in combination with Norelgestromin.
Chlorpropamide
Minor
The therapeutic efficacy of Chlorpropamide can be decreased when used in combination with Norelgestromin.
Flibanserin
Minor
The risk or severity of adverse effects can be increased when Norelgestromin is combined with Flibanserin.

Xulane Novel Uses: Which Conditions Have a Clinical Trial Featuring Xulane?

Nine investigations are currently being conducted to assess the potential of Xulane in providing Transdermal contraception therapy.
Condition
Clinical Trials
Trial Phases
Polycystic Ovarian Syndrome
6 Actively Recruiting
Not Applicable, Phase 1
Transdermal contraception therapy
0 Actively Recruiting

Xulane Reviews: What are patients saying about Xulane?

5Patient Review
4/12/2021
Xulane for Birth Control
I've been using this patch for a while now and I love it. The only issue I ever have is that, because I'm allergic to latex, I sometimes have to clean the area a bit more when I change the patch.
5Patient Review
6/27/2021
Xulane for Birth Control
Xulane has been a great product for me for the past 10 years. After my insurance switched me to Zafemy, I realized just how inferior that product was. Xulane sticks on properly and doesn't slide off, even when I'm sweating from playing tennis. It's also never given me any side effects, which is amazing.
2.3Patient Review
4/10/2022
Xulane for Birth Control
I was on Xulane for seven months and will never use it again. It made me nauseous at first, but that went away after a couple of months. However, the headaches started afterwards and were really bad. I also felt on edge all the time while taking this medication, and it made my skin break out in dark spots. In addition, it caused unwanted hair growth on my body and face. Finally, it made me gain a lot of weight—more than I did after having my baby! I had to stop taking it and switch to another pill. Now I feel so much better; even the mental fog has lifted
2.3Patient Review
7/18/2020
Xulane for Birth Control
I felt great while taking this medication, but I eventually realized that it was the cause of my migraines. I also broke out in hives during the second week.
1.7Patient Review
6/21/2021
Xulane for Birth Control
I was about to give up on the patch until I found Twirla. It sticks great and works. Apparently Twirla is the newest patch on the market and isn't available everywhere yet, but with how good it works, I'm sure it will be soon.
1Patient Review
6/6/2021
Xulane for Birth Control
I had two strokes while taking this medication. I'm only 19 and was very healthy prior to starting on this birth control. Other women have died from using the patch, and I wish I had never started taking it.
1Patient Review
6/14/2021
Xulane for Birth Control
I was really unhappy with this birth control. The packaging and patch changed, and I started having problems. Every time I would get into water, the patch would come off without me touching it at all. I would go through all 3 patches in a week and wouldn’t be able to get any until the next month. This is ridiculous.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about xulane

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Do you gain weight on Xulane?

"Xulane can sometimes lead to weight gain, which may manifest in the form of increased breast size. Xulane can also cause your body to hold on to more fluid, making your breast tissue more swollen."

Answered by AI

Is Xulane a good birth control?

"It made me gain weight and I had a lot of mood swings. I will never use it again,” said one reviewer.

The average rating for Xulane from all 435 ratings is 5.7 out of 10. 42% of reviewers reported having a positive experience while using Xulane, while 32% reported having a negative experience. One reviewer said, "I don't like Xulane. It made me gain weight and I had a lot of mood swings. I will never use it again.""

Answered by AI

What are the side effects of Xulane?

"You may experience skin irritation, nausea, vomiting, headache, bloating, breast tenderness, or weight change at the application site. You may also experience vaginal bleeding between periods (spotting), especially during the first few months of use."

Answered by AI

What is the weight limit for Xulane patch?

"If your weight is over 198 lbs (90 kg), XULANE may not be as effective and you should speak to your healthcare provider about which method of birth control would be better for you."

Answered by AI

Clinical Trials for Xulane

Image of Center for Human Nutrition in Fayetteville, United States.

Higher Protein Diet for PCOS

18 - 50
Female
Fayetteville, AR
Polycystic ovary syndrome (PCOS) is a significant public health problem and is one of the most common hormonal disturbances affecting women of reproductive age. Women with PCOS are often insulin resistant, increasing their risk for cardiometabolic health problems (e.g., type 2 diabetes, heart disease, high blood pressure, sleep apnea, anxiety, depression, and stroke) especially if they are overweight. Lifestyle modifications, including dietary changes and regular physical activity, may alleviate metabolic dysfunction in women with PCOS and are often the first line of management for patients with PCOS. Several studies have identified protein as a key nutrient for regulation of energy balance, maintenance of skeletal muscle mass, and improving cardiometabolic health across the lifespan. However, the effect of increased protein intake (30% of total energy intake) on cardiometabolic health in women with PCOS has not been well-defined and mechanisms for these effects have not been identified. There is an evident need for well-designed, randomized controlled trials evaluating the efficacy of increased protein intake in women with PCOS on markers of cardiometabolic health. Preliminary data from collaborative projects with the investigators on this proposal suggest that increasing protein in the diet has the potential to improve markers of cardiometabolic health, potentially through improvements in body composition and/or changes in cortisol, energy metabolism, inflammation, and neurological regulators
Recruiting
Has No Placebo
Center for Human Nutrition
Image of Center for Human Nutrition in Fayetteville, United States.

Protein Meals for Polycystic Ovary Syndrome

18 - 50
Female
Fayetteville, AR
Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by insulin resistance, hyperandrogenism, and reproductive dysfunction. Dietary strategies that improve postprandial insulin and glucose responses are central to managing metabolic symptoms in PCOS. Meals higher in protein can attenuate postprandial glycemia and enhance satiety, but the effects may vary by protein source. Animal sources of protein typically have higher essential amino acid content and insulinogenic potential, whereas plant proteins offer fiber and phytochemicals that may influence glycemic dynamics differently. Few studies have directly compared the acute metabolic effects of plant versus animal protein in women with PCOS. Given the distinct pathophysiology of PCOS, extrapolating findings from healthy populations may be misleading. Understanding protein-specific effects on postprandial insulin, glucose, and appetite-regulating hormones in this group is essential for targeted nutrition guidance. Additionally, plant-based diets are increasingly promoted for cardiometabolic health, but their acute effects in insulin-resistant women remain underexplored. This study will assess whether plant and animal protein meals elicit differential postprandial responses in women with PCOS. Findings may inform dietary recommendations aimed at improving metabolic outcomes in this high-risk population.
Recruiting
Has No Placebo
Center for Human NutritionJamie I Baum, PhD
Image of Cardiovascular Health and Autonomic Research Laboratory in Montréal, Canada.

Ketone Supplementation for Polycystic Ovary Syndrome

18 - 40
All Sexes
Montréal, Canada
Polycystic ovary syndrome (PCOS) affects 1 in 5 females of reproductive age. Commonly characterized as a disorder of infertility, PCOS is often accompanied by 3 potent cardiovascular disease (CVD) risk factors: insulin resistance, endothelial dysfunction, and elevated blood pressure. Accordingly, PCOS is associated with the development of CVD, the second leading cause of death in females in Canada. However, effective treatments to improve cardiovascular health in PCOS are lacking. Exogenous ketone monoester (KME) ingestion has been shown to improves outcomes associated with insulin resistance, endothelial function, and blood pressure regulation in healthy individuals and individuals predisposed to CVD. Therefore, oral ketone supplements offer a practical and effective strategy for improving cardiovascular health; however, this treatment has yet to be evaluated in PCOS. Therefore, the overall goal of this project is to employ KME ingestion to improve markers of cardiovascular health in females with PCOS. On two different days, participants will consume either a beverage containing a ketone supplement or a beverage containing a placebo supplement. The objectives are to compare responses between KME and placebo ingestion, and examine all outcomes related to cardiovascular health in females with PCOS in comparison with female controls of similar age and body mass index. The effects of KME ingestion will be quantified on: 1) glycemic control during an oral glucose tolerance test; 2) endothelial function using the flow-mediated dilation test; 3) blood pressure and acute blood pressure regulation; and 4) hemodynamic responses to acute exercise.
Recruiting
Paid Trial
Cardiovascular Health and Autonomic Research Laboratory (+1 Sites)Charlotte Usselman, Ph.D
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