Sequential vs Concurrent Chemotherapy with Radiation for Breast Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
In a small study at Johns Hopkins, women were treated with partial breast irradiation and chemotherapy given at the same time.We are now testing in a bigger study whether giving partial breast irradiation and chemotherapy at the same time (our new method) has the same side effects and outcomes as giving partial breast irradiation and chemotherapy at different times(older method). In this study women who had their breast cancer removed but need radiation to the breast will be randomized to partial breast irradiation at the same time as chemotherapy or partial breast radiation at a different time than chemotherapy. Randomization is like flipping a coin but in this study about 2 of every 3 women will get the new method.
Will I have to stop taking my current medications?
The trial protocol does not specify if you need to stop taking your current medications. It's best to discuss your specific situation with the study team or your doctor.
Is accelerated partial breast irradiation (APBI) safe for breast cancer patients?
How is the treatment Partial Breast Irradiation (PBI) different from other breast cancer treatments?
Partial Breast Irradiation (PBI) is unique because it targets only the part of the breast where cancer was removed, allowing for a shorter treatment time of 1 to 5 days compared to the 5-6 weeks required for whole-breast irradiation. This approach can reduce exposure to healthy tissue and may be more convenient for patients.26789
What data supports the effectiveness of the treatment Sequential vs Concurrent Chemotherapy with Radiation for Breast Cancer?
Who Is on the Research Team?
Richard Zellars, MD
Principal Investigator
Indiana University School of Medicine, Indiana University Simon Comprehensive Cancer Center
Are You a Good Fit for This Trial?
This trial is for women over 18 who've had breast cancer surgery with no remaining margins, have a performance status indicating they can carry out light activity, and need chemotherapy. They must not be pregnant, use effective birth control if of child-bearing potential, and have invasive adenocarcinoma of the breast treatable with specific chemo regimens.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive partial breast irradiation and chemotherapy, either concurrently or sequentially
Follow-up
Participants are monitored for safety and effectiveness after treatment
Long-term follow-up
Participants are monitored for long-term toxicities and tumor recurrence
What Are the Treatments Tested in This Trial?
Interventions
- Concurrent Chemotherapy
- Partial Breast Irradiation
- Sequential Chemotherapy
Partial Breast Irradiation is already approved in United States, European Union for the following indications:
- Early-stage invasive breast cancer
- Ductal carcinoma in situ (DCIS)
- Early-stage invasive breast cancer
- Ductal carcinoma in situ (DCIS)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Richard Zellars
Lead Sponsor