Oxytocin
Uterine Contraction, Negative Reinforcement, Abortion, Spontaneous + 7 more
Treatment
4 FDA approvals
5 Active Studies for Oxytocin
Treatment for
Uterine Contraction
What is Oxytocin
Oxytocin
The Generic name of this drug
Treatment Summary
Oxytocin is a hormone first discovered in 1906 that helps with the contraction of the uterus. In the 1950s, it was successfully made synthetically, which earned a Nobel Prize for the biochemist who created it. It is frequently used in obstetrics to help with labor and post-birth bleeding, and is used in around 10% of births globally. It should be used cautiously, though, since there can be risks associated with its use in childbirth. Oxytocin also has other roles in pair-bonding, social functioning, fear conditioning, metabolic balance and heart health.
Oxytocin
is the brand name
Oxytocin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Oxytocin
Oxytocin
1980
23
Approved as Treatment by the FDA
Oxytocin, also known as Oxytocin, is approved by the FDA for 4 uses such as Postpartum Bleeding and Uterine Contraction .
Postpartum Bleeding
Helps manage Postpartum Bleeding
Uterine Contraction
Hemorrhage
Helps manage Postpartum Bleeding
Uterine Contractions
Effectiveness
How Oxytocin Affects Patients
Oxytocin is a hormone that has many different effects on the body. It is most commonly associated with childbirth and breastfeeding, but it also influences metabolism, cardiac health, sexual behavior, social behavior, and fear responses. Oxytocin receptors are found not only in the reproductive system, but in many other tissues, including the brain stem and amygdala.
How Oxytocin works in the body
Oxytocin is a hormone released during childbirth that helps induce labor. It is produced in the brain and sent to the uterus, where it stimulates the uterine muscles to contract. As the baby's head pushes against the cervix, more oxytocin is released and the contractions increase as a result. Synthetic oxytocin can be used to help induce labor or increase the effectiveness of uterine contractions.
When to interrupt dosage
The recommended measure of Oxytocin is contingent upon the recognized disorder, including Incomplete Abortion, Induction of Labour and Inevitable abortion. The quantity of dosage differs as per the administration technique (e.g. Injection - Intramuscular; Intravenous or Injection, solution) expressed in the table beneath.
Condition
Dosage
Administration
Uterine Contraction
10.0 [USP'U]/mL, , 10.0 [iU]/mL, 0.01 [USP'U]/mL, 0.02 [USP'U]/mL, 0.3 [USP'U]/mL, 0.2 [USP'U]/mL, 0.03 [USP'U]/mL, 0.1 [USP'U]/mL, 10.0 units/mL
, Injection, Injection - Intramuscular; Intravenous, Intramuscular; Intravenous, Intravenous, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Solution, Liquid - Intramuscular; Intravenous, Liquid, Intramuscular; Intravascular, Injection - Intramuscular; Intravascular
Negative Reinforcement
10.0 [USP'U]/mL, , 10.0 [iU]/mL, 0.01 [USP'U]/mL, 0.02 [USP'U]/mL, 0.3 [USP'U]/mL, 0.2 [USP'U]/mL, 0.03 [USP'U]/mL, 0.1 [USP'U]/mL, 10.0 units/mL
, Injection, Injection - Intramuscular; Intravenous, Intramuscular; Intravenous, Intravenous, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Solution, Liquid - Intramuscular; Intravenous, Liquid, Intramuscular; Intravascular, Injection - Intramuscular; Intravascular
Abortion, Spontaneous
10.0 [USP'U]/mL, , 10.0 [iU]/mL, 0.01 [USP'U]/mL, 0.02 [USP'U]/mL, 0.3 [USP'U]/mL, 0.2 [USP'U]/mL, 0.03 [USP'U]/mL, 0.1 [USP'U]/mL, 10.0 units/mL
, Injection, Injection - Intramuscular; Intravenous, Intramuscular; Intravenous, Intravenous, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Solution, Liquid - Intramuscular; Intravenous, Liquid, Intramuscular; Intravascular, Injection - Intramuscular; Intravascular
reinforcement of labor
10.0 [USP'U]/mL, , 10.0 [iU]/mL, 0.01 [USP'U]/mL, 0.02 [USP'U]/mL, 0.3 [USP'U]/mL, 0.2 [USP'U]/mL, 0.03 [USP'U]/mL, 0.1 [USP'U]/mL, 10.0 units/mL
, Injection, Injection - Intramuscular; Intravenous, Intramuscular; Intravenous, Intravenous, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Solution, Liquid - Intramuscular; Intravenous, Liquid, Intramuscular; Intravascular, Injection - Intramuscular; Intravascular
Induction of Labour
10.0 [USP'U]/mL, , 10.0 [iU]/mL, 0.01 [USP'U]/mL, 0.02 [USP'U]/mL, 0.3 [USP'U]/mL, 0.2 [USP'U]/mL, 0.03 [USP'U]/mL, 0.1 [USP'U]/mL, 10.0 units/mL
, Injection, Injection - Intramuscular; Intravenous, Intramuscular; Intravenous, Intravenous, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Solution, Liquid - Intramuscular; Intravenous, Liquid, Intramuscular; Intravascular, Injection - Intramuscular; Intravascular
Abortion, Incomplete
10.0 [USP'U]/mL, , 10.0 [iU]/mL, 0.01 [USP'U]/mL, 0.02 [USP'U]/mL, 0.3 [USP'U]/mL, 0.2 [USP'U]/mL, 0.03 [USP'U]/mL, 0.1 [USP'U]/mL, 10.0 units/mL
, Injection, Injection - Intramuscular; Intravenous, Intramuscular; Intravenous, Intravenous, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Solution, Liquid - Intramuscular; Intravenous, Liquid, Intramuscular; Intravascular, Injection - Intramuscular; Intravascular
Third Stage of Labour
10.0 [USP'U]/mL, , 10.0 [iU]/mL, 0.01 [USP'U]/mL, 0.02 [USP'U]/mL, 0.3 [USP'U]/mL, 0.2 [USP'U]/mL, 0.03 [USP'U]/mL, 0.1 [USP'U]/mL, 10.0 units/mL
, Injection, Injection - Intramuscular; Intravenous, Intramuscular; Intravenous, Intravenous, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Solution, Liquid - Intramuscular; Intravenous, Liquid, Intramuscular; Intravascular, Injection - Intramuscular; Intravascular
Hemorrhage
10.0 [USP'U]/mL, , 10.0 [iU]/mL, 0.01 [USP'U]/mL, 0.02 [USP'U]/mL, 0.3 [USP'U]/mL, 0.2 [USP'U]/mL, 0.03 [USP'U]/mL, 0.1 [USP'U]/mL, 10.0 units/mL
, Injection, Injection - Intramuscular; Intravenous, Intramuscular; Intravenous, Intravenous, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Solution, Liquid - Intramuscular; Intravenous, Liquid, Intramuscular; Intravascular, Injection - Intramuscular; Intravascular
Labour
10.0 [USP'U]/mL, , 10.0 [iU]/mL, 0.01 [USP'U]/mL, 0.02 [USP'U]/mL, 0.3 [USP'U]/mL, 0.2 [USP'U]/mL, 0.03 [USP'U]/mL, 0.1 [USP'U]/mL, 10.0 units/mL
, Injection, Injection - Intramuscular; Intravenous, Intramuscular; Intravenous, Intravenous, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Solution, Liquid - Intramuscular; Intravenous, Liquid, Intramuscular; Intravascular, Injection - Intramuscular; Intravascular
Uterine Contractions
10.0 [USP'U]/mL, , 10.0 [iU]/mL, 0.01 [USP'U]/mL, 0.02 [USP'U]/mL, 0.3 [USP'U]/mL, 0.2 [USP'U]/mL, 0.03 [USP'U]/mL, 0.1 [USP'U]/mL, 10.0 units/mL
, Injection, Injection - Intramuscular; Intravenous, Intramuscular; Intravenous, Intravenous, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Solution - Intramuscular; Intravenous, Solution, Liquid - Intramuscular; Intravenous, Liquid, Intramuscular; Intravascular, Injection - Intramuscular; Intravascular
Warnings
Oxytocin has nine contraindications, so it should not be utilized in the presence of the conditions detailed in the following table.
Oxytocin Contraindications
Condition
Risk Level
Notes
Cephalopelvic Disproportion
Do Not Combine
unfavorable fetal presentations
Do Not Combine
Obstetrical Emergency Situations
Do Not Combine
Breech Presentation
Do Not Combine
unsatisfactory progress from adequate uterine activity
Do Not Combine
Obstetric Delivery
Do Not Combine
hyperactive or hypertonic uterus
Do Not Combine
Vaginal Delivery Contraindicated
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Oxytocin may interact with Pulse Frequency
There are 20 known major drug interactions with Oxytocin.
Common Oxytocin Drug Interactions
Drug Name
Risk Level
Description
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Oxytocin is combined with Hydroxyzine.
Mobocertinib
Major
The risk or severity of QTc prolongation can be increased when Oxytocin is combined with Mobocertinib.
Ziprasidone
Major
The risk or severity of QTc prolongation can be increased when Oxytocin is combined with Ziprasidone.
Abexinostat
Minor
The risk or severity of QTc prolongation can be increased when Oxytocin is combined with Abexinostat.
Aceprometazine
Minor
The risk or severity of QTc prolongation can be increased when Oxytocin is combined with Aceprometazine.
Oxytocin Toxicity & Overdose Risk
Taking too much oxytocin can cause a lack of blood to the heart, rapid heartbeat, and irregular heartbeat. It can also cause strong contractions of the uterus, which can be dangerous. Taking large doses of oxytocin daily can lead to water intoxication which may result in seizures, coma, or death. If fluids are taken orally the risk is even greater.
Oxytocin Novel Uses: Which Conditions Have a Clinical Trial Featuring Oxytocin?
At present, 3 active trials are evaluating the potential of Oxytocin to provide Negative Reinforcement, induce labor and treat Inevitable abortions.
Condition
Clinical Trials
Trial Phases
Abortion, Incomplete
0 Actively Recruiting
Uterine Contractions
1 Actively Recruiting
Not Applicable
Uterine Contraction
1 Actively Recruiting
Not Applicable
Negative Reinforcement
0 Actively Recruiting
Third Stage of Labour
0 Actively Recruiting
reinforcement of labor
0 Actively Recruiting
Hemorrhage
0 Actively Recruiting
Induction of Labour
1 Actively Recruiting
Phase 4
Labour
2 Actively Recruiting
Phase 4, Phase 3
Abortion, Spontaneous
0 Actively Recruiting
Patient Q&A Section about oxytocin
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Does oxytocin increase love?
"The "love hormone" oxytocin is responsible for some of the positive emotions associated with attraction and sexual desire."
Answered by AI
What stimulates oxytocin?
"The physical affection shown between adults can cause oxytocin to be released, which can in turn make the bond between them stronger. Oxytocin is known as one of the happy hormones because it has such a positive effect on emotions and mood, so it's no wonder that it's often thought of in a positive light."
Answered by AI
What does oxytocin do in love?
"When you hug or kiss a loved one, your pituitary gland releases oxytocin, which is especially important for pair bonding, like in romantic relationships, as it elevates your mood and makes you feel more "attached" to your romantic partner."
Answered by AI
What are 4 roles of oxytocin?
"In the brain, oxytocin works as a chemical messenger and plays an important role in many human behaviors, such as sexual arousal, recognition, trust, and romantic attachment. It also plays a role in mother-infant bonding."
Answered by AI
Why is oxytocin called the love drug?
"Oxytocin is sometimes called the "love hormone" or the "cuddle hormone" because it is released when people fall in love or hug. Oxytocin is also released during sexual activity and childbirth."
Answered by AI
What triggers oxytocin release?
"Oxytocin is released by the body in response to various stimuli, such as during labor, breastfeeding, sexual activity, or even just simple things like touching or being touched."
Answered by AI