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What is Viorele
DesogestrelThe Generic name of this drug
Treatment SummaryDesogestrel is a hormone-based drug used to treat reproductive health conditions. It is a synthetic form of the naturally occurring hormones found in plants and was first developed in 1972. Desogestrel is only available in combination with ethinyl estradiol in the US, and was approved by the FDA in 1992.
Desogenis the brand name
Viorele Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Desogen
Desogestrel
1992
68
Effectiveness
How Viorele Affects PatientsDesogestrel affects many areas of the body, including the reproductive system (it can delay the start of a period, change hormone levels, and make the vaginal fluid thicker), metabolism (increase insulin secretion and resistance, increase lipase activity, and increase fat deposition), and more. It mainly works by stopping ovulation in 97% of cases. Desogestrel has also been linked to an increased risk of blood clotting, but it does not typically have a significant effect on total cholesterol levels.
How Viorele works in the bodyDesogestrel works by entering cells and attaching to the progesterone receptor. This switches on certain genes that cause changes in the production of mRNA. The active metabolite of desogestrel, etonogestrel, also has strong progestational activity with very little androgenic effects.
When to interrupt dosage
The proposed dose of Viorele is contingent upon the indicated condition, such as Birth Control, Nursing Women and Hormonal Contraception. The measure of dosage depends upon the technique of administration (e.g. Kit or Kit; Tablet - Oral), as delineated in the table below.Condition
Dosage
Administration
Hormonal Contraception
, 0.15 mg, 0.1 mg, 0.125 mg, 0.375 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Birth Control
, 0.15 mg, 0.1 mg, 0.125 mg, 0.375 mg
, Kit, Oral, Tablet, Tablet - Oral, Kit - Oral
Warnings
Viorele has twenty-five contraindications and should not be taken in alliance with the disorders indicated in the following table.Viorele ContraindicationsCondition
Risk Level
Notes
Cerebrovascular Diseases
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Liver Cancer
Do Not Combine
Endometrial Carcinoma
Do Not Combine
Thromboembolism
Do Not Combine
Thromboembolism
Do Not Combine
Major Surgery
Do Not Combine
benign hepatic adenoma
Do Not Combine
Breast Cancer
Do Not Combine
hepatocellular disease
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
Breast
Do Not Combine
Type 2 Diabetes
Do Not Combine
Coronary Artery Disease (CAD)
Do Not Combine
Thrombophlebitis
Do Not Combine
Thrombophilia
Do Not Combine
Diastolic blood pressure
Do Not Combine
> 160 mm Hg systolic blood pressure
Do Not Combine
Jaundice, Obstructive
Do Not Combine
history of deep vein thrombophlebitis
Do Not Combine
Icterus
Do Not Combine
focal neurological symptoms
Do Not Combine
valvular heart disease with complications
Do Not Combine
estrogen-dependent neoplasia
Do Not Combine
Common Viorele Drug Interactions
Drug Name
Risk Level
Description
Axitinib
Major
The metabolism of Axitinib can be increased when combined with Desogestrel.
Belinostat
Major
The metabolism of Belinostat can be increased when combined with Desogestrel.
Binimetinib
Major
The metabolism of Binimetinib can be increased when combined with Desogestrel.
Enasidenib
Major
The metabolism of Enasidenib can be increased when combined with Desogestrel.
Etoposide
Major
The metabolism of Etoposide can be increased when combined with Desogestrel.
Viorele Toxicity & Overdose RiskTaking a large amount of desogestrel may cause strong hormonal effects but not long-term harm. In rats, the toxic dose was found to be higher than 2000mg/kg. Overdosing on desogestrel may cause nausea and stop menstruation, but it is not known to increase the risk of breast cancer. Some studies suggest a potential increased risk of cervical intra-epithelial neoplasia, but this has yet to be proven.
Viorele Novel Uses: Which Conditions Have a Clinical Trial Featuring Viorele?
38 active clinical trials are evaluating the potential of Viorele to provide Nursing Women, Birth Control and Hormonal Contraception for the treatment of certain disorders.Condition
Clinical Trials
Trial Phases
Birth Control
31 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Early Phase 1
Hormonal Contraception
0 Actively Recruiting
Viorele Reviews: What are patients saying about Viorele?
5Patient Review
4/25/2020 I've been on this prescription for over two years and it's never given me any problems. My skin is clear, my hormones are under control, and most importantly- I'm not pregnant. Every drug works differently for different people, but this one works for me. I recommend the pill to all my friends who are looking for contraception. I also skip my periods; the last time I had a period was about five months ago. I love being on the pill!
4.7Patient Review
8/6/2019 Viorele has been my go-to for a few years now. Prior to taking this medication, my periods were incredibly painful to the point where I would feel nauseous and have heavy bleeding that would last for days on end. Viorele has helped immensely with both cramping and acne, though I have noticed a significant decrease in libido.
2.3Patient Review
1/15/2019 I started taking this medication and saw an unfortunate uptick in the number of pimples, as well as their severity. It was all over my face, painful, and made me very insecure. Additionally, it caused difficulty sleeping and increased moodiness.
2.3Patient Review
2/28/2020 CVS's change from Kariva to Viorele has really messed with my head twice now. I had mood swings and felt depressed both times.
2.3Patient Review
4/2/2017 I've been on this pill for 12 days and have found myself to be much more moody than usual. I'm going back to my old pill immediately.
1Patient Review
2/22/2018 Do not take this medication! I have experienced bloating, nausea, weight/appetite gain (it's been 12 days), extreme rage, breast tenderness and lumps. I have probably gained 5 pounds in less than two weeks.
Patient Q&A Section about viorele
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What type of birth control is Viorele?
"The Viorele birth control pill contains female hormones that prevent ovulation (the release of an egg from an ovary). Viorele also causes changes in your cervical mucus and uterine lining, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus."
Answered by AI
What is Viorele used for?
"This medication, which contains a combination of two hormones (a progestin and an estrogen), is used to prevent pregnancy."
Answered by AI
Does Viorele cause weight gain?
"Can Viorele cause weight gain? Some women worry about this when taking Viorele and other birth control pills. While it might make you feel hungrier, it's mostly water retention (and not actual fat) that's to blame."
Answered by AI
Does Viorele make you depressed?
"I wouldn't recommend it.”
I had a terrible experience with Viorele, and it only took a couple days for the anxiety and depression to set in. It's been just over a week now, and the drug has caused me anxiety attacks and problems in my relationships, as well as abdominal cramps. It made me feel dizzy and out of it, too. I wouldn't recommend it to anyone."
Answered by AI