Nuvigil

Sleepiness, Narcolepsy, Sleep Disorders, Circadian Rhythm
Treatment
5 FDA approvals
13 Active Studies for Nuvigil

What is Nuvigil

ArmodafinilThe Generic name of this drug
Treatment SummaryArmodafinil is a prescription medication used to treat excessive sleepiness associated with obstructive sleep apnea, narcolepsy, or shift work disorder. It is the R-enantiomer of the wakefulness-promoting agent modafinil and has been approved by the FDA since 2007. Armodafinil has been shown to help improve driving simulator performance in people with shift work disorder. The drug is manufactured by Cephalon Inc (a subsidiary of Teva Pharmaceutical Industries Ltd).
Nuvigilis the brand name
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Nuvigil Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Nuvigil
Armodafinil
2009
66

Approved as Treatment by the FDA

Armodafinil, commonly known as Nuvigil, is approved by the FDA for 5 uses which include Somnolence and Shift-work related sleep disturbance .
Somnolence
Helps manage Somnolence
Shift-work related sleep disturbance
Helps manage Shift-work related sleep disturbance
Narcolepsy
Helps manage Narcolepsy
Sleep Disorders, Circadian Rhythm
Helps manage Shift-work related sleep disturbance
Sleepiness
Helps manage Somnolence

Effectiveness

How Nuvigil works in the bodyNuvigil (armodafinil) is a stimulant that helps people stay awake and alert for longer periods of time. We don't know exactly how it works, but it does not interact with several key receptors and enzymes that are related to wake/sleep regulation. Armodafinil does bind to the dopamine transporter and stops dopamine from being reabsorbed, which likely plays a role in its effects.

When to interrupt dosage

The prescribed measure of Nuvigil is contingent upon the recognized condition, including Narcolepsy, Shift-work related sleep disturbance and Somnolence. The amount of dosage is contingent upon the approach of administration outlined in the below table.
Condition
Dosage
Administration
Sleepiness
, 250.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral
Narcolepsy
, 250.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral
Sleep Disorders, Circadian Rhythm
, 250.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral

Warnings

There are 20 known major drug interactions with Nuvigil.
Common Nuvigil Drug Interactions
Drug Name
Risk Level
Description
Anagrelide
Major
The metabolism of Anagrelide can be increased when combined with Armodafinil.
Bendamustine
Major
The metabolism of Bendamustine can be increased when combined with Armodafinil.
Cabozantinib
Major
The metabolism of Cabozantinib can be decreased when combined with Armodafinil.
Capecitabine
Major
The metabolism of Capecitabine can be decreased when combined with Armodafinil.
Capmatinib
Major
The serum concentration of Capmatinib can be decreased when it is combined with Armodafinil.
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Nuvigil Novel Uses: Which Conditions Have a Clinical Trial Featuring Nuvigil?

Currently, 13 trials are underway to assess the potential of Nuvigil to alleviate Shift-work related sleep disturbance, Somnolence and Narcolepsy.
Condition
Clinical Trials
Trial Phases
Sleep Disorders, Circadian Rhythm
6 Actively Recruiting
Not Applicable, Phase 2, Phase 3
Narcolepsy
1 Actively Recruiting
Phase 1
Sleepiness
7 Actively Recruiting
Not Applicable, Phase 3

Nuvigil Reviews: What are patients saying about Nuvigil?

5Patient Review
9/30/2016
Nuvigil for Sleepiness Due To Obstructive Sleep Apnea
This medication has been a life-saver, helping me to stay awake and alert while driving at early morning hours during the week. I have experienced no adverse side effects from taking Nuvigol for over a year, and my sleep patterns have also dramatically improved.
5Patient Review
10/5/2019
Nuvigil for Recurring Sleep Episodes During the Day
I've only taken the nuvigil twice and both times I experienced anxiety, sweating, and more anxiety. I'm hoping this is just a normal side effect that will pass with time. So far, it's keeping me awake which is great. But I worry about the other effects.
5Patient Review
6/1/2017
Nuvigil for Sleepiness Due To Shift Work Sleep Disorder
The pro of this drug is that it really helped me stay awake during the day. The con was that I got horrible headaches and felt exhausted by the end of the day.
5Patient Review
1/17/2016
Nuvigil for Sleepiness Due To Obstructive Sleep Apnea
5Patient Review
7/21/2016
Nuvigil for Sleepiness Due To Shift Work Sleep Disorder
This medication has helped me a lot. It's easy to remember to take it in the morning, and I haven't had any problems with side effects.
View All Reviews
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Patient Q&A Section about nuvigil

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How does Nuvigil make you feel?

"The doctor warned me that Nuvigil could make me feel "jittery". As someone who is naturally jittery and takes an anti-anxiety medication, I was skeptical. I decided to do a sleep study to see if the drug would help me."

Answered by AI

What is Nuvigil used to treat?

"Armodafinil helps to reduce extreme sleepiness that is caused by narcolepsy and other sleep disorders, like when you stop breathing during sleep (obstructive sleep apnea)."

Answered by AI

Is Nuvigil the same as Adderall?

"What is the difference between Armodafinil and Adderall?

Armodafinil is similar to Adderall in that they can both improve wakefulness and alertness; however, they work differently in the brain and affect different chemicals. Armodafinil is classified as a controlled medication differently than Adderall."

Answered by AI

What does Nuvigil do to the brain?

"Nuvigil and Provigil help to Wake people up by stimulating certain areas of the brain. These drugs can be used to treat narcolepsy, Sleep apnea, and shift work disorder."

Answered by AI

Clinical Trials for Nuvigil

Have you considered Nuvigil clinical trials? We made a collection of clinical trials featuring Nuvigil, we think they might fit your search criteria.
Have you considered Nuvigil clinical trials? We made a collection of clinical trials featuring Nuvigil, we think they might fit your search criteria.
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