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What is Nuvigil
ArmodafinilThe Generic name of this drug
Treatment SummaryArmodafinil is a prescription medication used to treat excessive sleepiness associated with obstructive sleep apnea, narcolepsy, or shift work disorder. It is the R-enantiomer of the wakefulness-promoting agent modafinil and has been approved by the FDA since 2007. Armodafinil has been shown to help improve driving simulator performance in people with shift work disorder. The drug is manufactured by Cephalon Inc (a subsidiary of Teva Pharmaceutical Industries Ltd).
Nuvigilis the brand name
Nuvigil Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Nuvigil
Armodafinil
2009
66
Approved as Treatment by the FDA
Armodafinil, commonly known as Nuvigil, is approved by the FDA for 3 uses which include Sleepiness and Narcolepsy .Sleepiness
Helps manage Somnolence
Narcolepsy
Helps manage Narcolepsy
Shift-work related sleep disturbance
Helps manage Shift-work related sleep disturbance
Effectiveness
How Nuvigil works in the bodyNuvigil (armodafinil) is a stimulant that helps people stay awake and alert for longer periods of time. We don't know exactly how it works, but it does not interact with several key receptors and enzymes that are related to wake/sleep regulation. Armodafinil does bind to the dopamine transporter and stops dopamine from being reabsorbed, which likely plays a role in its effects.
When to interrupt dosage
The prescribed measure of Nuvigil is contingent upon the recognized condition, including Narcolepsy, Shift-work related sleep disturbance and Somnolence. The amount of dosage is contingent upon the approach of administration outlined in the below table.Condition
Dosage
Administration
Sleepiness
, 250.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral
Narcolepsy
, 250.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral
Shift-work related sleep disturbance
, 250.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral
Warnings
There are 20 known major drug interactions with Nuvigil.Common Nuvigil Drug Interactions
Drug Name
Risk Level
Description
Anagrelide
Major
The metabolism of Anagrelide can be increased when combined with Armodafinil.
Bendamustine
Major
The metabolism of Bendamustine can be increased when combined with Armodafinil.
Cabozantinib
Major
The metabolism of Cabozantinib can be decreased when combined with Armodafinil.
Capecitabine
Major
The metabolism of Capecitabine can be decreased when combined with Armodafinil.
Capmatinib
Major
The serum concentration of Capmatinib can be decreased when it is combined with Armodafinil.
Nuvigil Novel Uses: Which Conditions Have a Clinical Trial Featuring Nuvigil?
Currently, 13 trials are underway to assess the potential of Nuvigil to alleviate Shift-work related sleep disturbance, Somnolence and Narcolepsy.Condition
Clinical Trials
Trial Phases
Narcolepsy
10 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 4, Phase 1
Shift-work related sleep disturbance
6 Actively Recruiting
Not Applicable, Phase 4, Phase 2
Sleepiness
1 Actively Recruiting
Phase 4
Nuvigil Reviews: What are patients saying about Nuvigil?
5Patient Review
9/30/2016 This medication has been a life-saver, helping me to stay awake and alert while driving at early morning hours during the week. I have experienced no adverse side effects from taking Nuvigol for over a year, and my sleep patterns have also dramatically improved.
5Patient Review
10/5/2019 I've only taken the nuvigil twice and both times I experienced anxiety, sweating, and more anxiety. I'm hoping this is just a normal side effect that will pass with time. So far, it's keeping me awake which is great. But I worry about the other effects.
5Patient Review
6/1/2017 The pro of this drug is that it really helped me stay awake during the day. The con was that I got horrible headaches and felt exhausted by the end of the day.
5Patient Review
1/17/20165Patient Review
7/21/2016 This medication has helped me a lot. It's easy to remember to take it in the morning, and I haven't had any problems with side effects.
5Patient Review
6/9/2017 I take this medication a half hour before my night shift, and it allows me to stay fully alert and focused for the entire duration.
4.3Patient Review
7/1/2016 Nuvigil is great for me because I'm very sensitive to stimulants. It doesn't make me anxious or give me palpitations like other drugs do; instead it just keeps me more awake and full of energy.
4Patient Review
7/13/2018 Though it's a bit pricey, I found this treatment completely worth the investment.
3.7Patient Review
2/6/2016 I experienced great results for the first two days of taking this medication. However, after that I started having migraines, dizziness, breathing difficulties, and an irregular heartbeat. Needless to say, I won't be continuing to take it.
3.3Patient Review
5/7/2019 I started taking this once daily, but then began experiencing heart palpitations, chest tightness and shortness of breath. My cardiologist ruled out any underlying cardiac conditions, but all of my symptoms were related to this medication. I'm now much more careful about when I take it and have had no further problems.
3.3Patient Review
12/7/2020 I've been using this medication for about a month now, and it seems to be working well. I have noticed that I'm not as emotionally stable as I used to be, and I get easily triggered when someone interrupts me. Also started getting headaches about a week ago, but those could be unrelated.
1.7Patient Review
4/5/2016 I find that this medication is most effective on the days when I don't take it and just sleep all day.
1Patient Review
9/25/2021 I didn't have a good experience with this medication. It made me feel jittery, angry, and extremely sleepy, and I also got headaches from it.
1Patient Review
10/22/2020 Nuvigil was helpful for me at first, but it's stopped being effective in the last year or so. I'm currently discussing alternatives with my doctor.
1Patient Review
1/11/2016Patient Q&A Section about nuvigil
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Nuvigil used to treat?
"Armodafinil helps to reduce extreme sleepiness that is caused by narcolepsy and other sleep disorders, like when you stop breathing during sleep (obstructive sleep apnea)."
Answered by AI
Is Nuvigil the same as Adderall?
"What is the difference between Armodafinil and Adderall?
Armodafinil is similar to Adderall in that they can both improve wakefulness and alertness; however, they work differently in the brain and affect different chemicals. Armodafinil is classified as a controlled medication differently than Adderall."
Answered by AI
What does Nuvigil do to the brain?
"Nuvigil and Provigil help to Wake people up by stimulating certain areas of the brain. These drugs can be used to treat narcolepsy, Sleep apnea, and shift work disorder."
Answered by AI