30 Participants Needed

Partial Sleep Deprivation for Sleep

BC
MO
Overseen ByMichael Ormsbee
Age: 18 - 65
Sex: Any
Trial Phase: Academic
Sponsor: Florida State University
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

What is the purpose of this trial?

The goal of this interventional study is to differentiate the effects of an acute partial sleep deprivation intervention on markers of cardiovascular health, cardio-autonomic function, physical and cognitive performance, as well as overall wellbeing in active vs sedentary individuals. The main aims of the project are: * To differentiate the effects of partial sleep deprivation on central hemodynamics (i.e., central blood pressure and arterial stiffness) in active vs sedentary individuals. * To differentiate the effects of partial sleep deprivation on physical (i.e., handgrip strength and reactive strength index) and cognitive performance (i.e., reaction time and impulse control) in active vs sedentary individuals. * To differentiate the effects of partial sleep deprivation on overall wellbeing (i.e., cardio-autonomic function, inflammation levels, and psychological mood states) in active vs sedentary individuals. Participants will be divided into two groups based on aerobic activity level - active or sedentary - and assessed for markers of cardiovascular health, cardio-autonomic function, physical and cognitive performance, as well as overall wellbeing before and after three days of normal sleep and three days of partially deprived sleep (i.e., 30% reduction in total time in bed).

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications.

What data supports the effectiveness of the treatment Partial Sleep Deprivation for sleep?

Research shows that partial sleep deprivation, where patients are kept awake for part of the night, can significantly reduce symptoms of depression. In several studies, many patients experienced a noticeable improvement in their mood after undergoing this treatment, suggesting it can be an effective short-term therapy for depression.12345

Is partial sleep deprivation safe for humans?

Partial sleep deprivation can lead to negative effects on health, such as impaired cognitive performance, increased fatigue, and potential long-term health issues like cardiovascular disease and diabetes. However, it has been used as a therapy for depression, showing some positive effects, but the safety and impact can vary among individuals.678910

How is partial sleep deprivation treatment different from other sleep treatments?

Partial sleep deprivation is unique because it involves intentionally reducing sleep time, which can temporarily improve mood and alertness, unlike other treatments that aim to increase sleep duration or quality. This approach is different from standard treatments like positive airway pressure (PAP) therapy, which focuses on treating sleep-disordered breathing by maintaining open airways during sleep.1112131415

Eligibility Criteria

This trial is for individuals who are either physically active or sedentary, to study how not getting enough sleep affects heart health, physical and mental performance, and overall wellbeing. Participants will be assessed before and after having normal sleep and then less sleep than usual.

Inclusion Criteria

Chronically active (≥150 minutes of moderate- and/or ≥75 minutes of vigorous-intensity aerobic exercise per week for the last 3 months)
Sedentary (≤60 minutes of aerobic exercise per week for the last 3 months)

Exclusion Criteria

Pregnant
Poor sleep (regularly achieving <7 hours of sleep per night)
I am significantly overweight.
See 2 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Baseline Assessment

Participants are assessed for markers of cardiovascular health, cardio-autonomic function, physical and cognitive performance, as well as overall wellbeing before the sleep intervention

1 week
1 visit (in-person)

Intervention

Participants undergo three days of normal sleep followed by three days of partial sleep deprivation (30% reduction in total time in bed)

6 days
Daily monitoring

Post-Intervention Assessment

Participants are assessed immediately and 3 days after the intervention for changes in cardiovascular health, cardio-autonomic function, physical and cognitive performance, and overall wellbeing

1 week
2 visits (in-person)

Follow-up

Participants are monitored for any long-term effects of the intervention

4 weeks

Treatment Details

Interventions

  • Partial Sleep Deprivation
Trial Overview The study looks at the impact of cutting down on sleep by 30% over three days on various aspects like blood pressure, muscle strength, reaction time, mood states, inflammation levels in both active people and those with a sedentary lifestyle.
Participant Groups
2Treatment groups
Experimental Treatment
Active Control
Group I: Acute Partial Sleep DeprivationExperimental Treatment1 Intervention
30% reduction in habitual time in bed
Group II: Normal SleepActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Florida State University

Lead Sponsor

Trials
234
Recruited
41,100+

Findings from Research

In a 25-day trial involving 18 patients with treatment-resistant depression, periodic sleep deprivation combined with ongoing medication showed better results than medication alone, suggesting a potential enhancement in treatment efficacy.
Some patients experienced rapid recovery after just one or a few sessions of sleep deprivation, indicating that this approach may accelerate remission from depressive episodes.
Periodic sleep deprivation in drug-refractory depression.Dessauer, M., Goetze, U., Tölle, R.[2018]
In a study of 23 unmedicated patients with major depressive disorder, it was found that lower baseline REM density in sleep correlated with a greater antidepressant response to late-night partial sleep deprivation, suggesting REM density may be a marker for treatment response.
The study indicates that increased REM density could be linked to poorer prognosis in psychiatric disorders, highlighting its potential role in understanding depression and treatment outcomes.
Preliminary evidence of an association between increased REM density and poor antidepressant response to partial sleep deprivation.Clark, C., Dupont, R., Golshan, S., et al.[2019]
Sleep deprivation is linked to serious health issues such as increased risk of all-cause mortality, diabetes, and cardiovascular disease, highlighting the importance of addressing sleep disorders for public health.
Treating obstructive sleep apnea is a cost-effective healthcare intervention, providing significant quality-adjusted life years gained compared to other medical therapies, making it a valuable focus for improving patient outcomes.
The public health and safety consequences of sleep disorders.Sigurdson, K., Ayas, NT.[2007]

References

The timing of partial sleep deprivation in depression. [2019]
Serial partial sleep deprivation in depression--clinical effects and dexamethasone suppression test results. [2017]
Periodic sleep deprivation in drug-refractory depression. [2018]
Partial sleep deprivation as therapy for depression. [2019]
Preliminary evidence of an association between increased REM density and poor antidepressant response to partial sleep deprivation. [2019]
The public health and safety consequences of sleep disorders. [2007]
Neurocognitive consequences of sleep deprivation. [2022]
A sleep intervention study comparing effects of sleep restriction and fragmentation on sleep and vigilance and the need for recovery. [2021]
Partial sleep deprivation: impact on the architecture and quality of sleep. [2022]
10.United Statespubmed.ncbi.nlm.nih.gov
Sleep deprivation therapy. [2019]
Advanced prostate cancer treated with intermittent or continuous androgen deprivation in the randomised FinnProstate Study VII: quality of life and adverse effects. [2022]
12.United Statespubmed.ncbi.nlm.nih.gov
New Protocol of Intermittent Androgen Deprivation Therapy for Patients With Metastatic Prostate Cancer: A Retrospective Study. [2020]
13.United Statespubmed.ncbi.nlm.nih.gov
Intermittent androgen suppression in the management of prostate cancer. [2019]
14.United Statespubmed.ncbi.nlm.nih.gov
Applying adherent DBT Principles to treatment in a partial hospital setting: An analysis over 5-years of outcomes from intake to discharge. [2021]
15.United Statespubmed.ncbi.nlm.nih.gov
Advances in Treatment of Sleep-Disordered Breathing. [2021]
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