Sleep Apnea Clinical Trials 2022

Browse 108 Sleep Apnea Medical Studies Across 147 Cities

4 Phase 3 Trial · 325 Sleep Apnea Clinics

Reviewed by Michael Gill, B. Sc.
Phase-Based Progress Estimates

Mild Intermittent Hypoxia (MIH)for Obstructive Sleep Apnea (OSA)

Detroit, MI
18 - 65
All Sexes
The prevalence of obstructive sleep apnea (OSA) is high in the United States and is a major health concern. This disorder is linked to numerous heart, blood vessel and nervous system abnormalities, along with increased tiredness while performing exercise likely because of a reduced blood supply to skeletal muscles. The gold standard treatment of OSA with continuous positive airway pressure (CPAP) in many cases does not lead to significant improvements in health outcomes because the recommended number of hours of treatment per night is often not achieved. Thus, development of novel treatments to eliminate apnea and lessen the occurrence of associated health conditions is important. The investigators will address this mandate by determining if repeated exposure to mild intermittent hypoxia (MIH) reduces heart and blood vessel dysfunction and tiredness/ fatigue experienced while exercise performance. The investigators propose that exposure to MIH has a multipart effect. MIH directly targets heart and blood vessel associated conditions, while simultaneously increasing upper airway stability and improving sleep quality. These modifications may serve to directly decrease breathing episodes and may also serve to improve usage of CPAP. Independent of its effect, MIH may serve as an adjunctive therapy which provides another path to reducing heart and blood vessel abnormalities that might ultimately result in improvements in exercise capacity and reverse performance fatigue in individuals with OSA.
Phase 1 & 2
Waitlist Available
25 Sleep Apnea Clinical Trials Near Me
Detroit, MI
Toronto, Canada
Toronto, Canada
Rochester, MN
More Trial Locations
An interactive map to display trial locations for John D. Dingell VA Medical Center, Detroit, MI, KITE Toronto Research Institute, Hospital for Sick Children, Mayo Clinic in Rochester, and 38 more locations.
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Altman Clinical and Translational Research Institute Building
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About The Author

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 12th, 2021

Last Reviewed: August 22nd, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.