Hyperoxia/oxygen for Sleep Apnea

Phase-Based Progress Estimates
3
Effectiveness
3
Safety
Sleep Apnea+1 MoreHyperoxia/oxygen - Other
Eligibility
60 - 89
All Sexes
What conditions do you have?
Select

Study Summary

This trial will test whether oxygen, finasteride, and acetazolamide can be effective in reducing unstable breathing and eliminating sleep apnea in the elderly via different mechanisms.

Eligible Conditions
  • Sleep Apnea
  • Elderly Adults

Treatment Effectiveness

Effectiveness Progress

3 of 3
This is further along than 93% of similar trials

Study Objectives

4 Primary · 1 Secondary · Reporting Duration: 2 days to 30 days

Day 30
Apnea hypopnea index
Apneic threshold- a measure of breathing instability
Carbon -dioxide reserve
Ventilatory responsiveness
7 days
Cerebrovascular responsiveness to carbon-dioxide

Trial Safety

Safety Progress

3 of 3
This is further along than 85% of similar trials

Trial Design

3 Treatment Groups

Hyperoxia
1 of 3
Acetazolamide (ACZ)
1 of 3
Finasteride
1 of 3

Experimental Treatment

100 Total Participants · 3 Treatment Groups

Primary Treatment: Hyperoxia/oxygen · No Placebo Group · Phase 4

Hyperoxia
Other
Experimental Group · 1 Intervention: Hyperoxia/oxygen · Intervention Types: Other
Acetazolamide (ACZ)
Drug
Experimental Group · 1 Intervention: Acetazolamide · Intervention Types: Drug
Finasteride
Drug
Experimental Group · 1 Intervention: Finasteride · Intervention Types: Drug
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Finasteride
FDA approved
Acetazolamide
FDA approved

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 2 days to 30 days

Who is running the clinical trial?

VA Office of Research and DevelopmentLead Sponsor
1,485 Previous Clinical Trials
2,742,178 Total Patients Enrolled
8 Trials studying Sleep Apnea
1,128 Patients Enrolled for Sleep Apnea
Susmita Chowdhuri, MDPrincipal InvestigatorJohn D. Dingell VA Medical Center, Detroit, MI
4 Previous Clinical Trials
600 Total Patients Enrolled
3 Trials studying Sleep Apnea
492 Patients Enrolled for Sleep Apnea

Eligibility Criteria

Age 60 - 89 · All Participants · 2 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
For the finasteride protocol, men aged 60 years or older will be enrolled.

Who else is applying?

What state do they live in?
New Jersey50.0%
Michigan50.0%
How old are they?
18 - 65100.0%
What portion of applicants met pre-screening criteria?
Did not meet criteria50.0%
Met criteria50.0%
What site did they apply to?
John D. Dingell VA Medical Center, Detroit, MI100.0%

How responsive is this trial?

Typically responds via
Email100.0%
Average response time
  • < 2 Days
Most responsive sites:
  1. John D. Dingell VA Medical Center, Detroit, MI: < 48 hours