This trial will study if a mild diuretic drug, acetazolamide, can improve sleep apnea & cardiovascular health in young adults, offering an alternative treatment for millions of OSA patients who are unable to tolerate current treatments.
- Obstructive Sleep Apnea
2 Primary · 8 Secondary · Reporting Duration: 14 days
2 Treatment Groups
Acetazolamide, then Placebo, then optional open-label CPAP-therapy
1 of 2
Placebo, then Acetazolamide, then optional open-label CPAP-therapy
1 of 2
46 Total Participants · 2 Treatment Groups
Primary Treatment: Treatment · Has Placebo Group · Phase 2
Who is running the clinical trial?
Age 18 - 50 · All Participants · 1 Total Inclusion CriteriaMark “Yes” if the following statements are true for you:
Frequently Asked Questions
What criteria is necessary to qualify for this research program?
"Candidates satisfying the criteria of 18-50 years old and having been diagnosed with obstructive sleep apnea (OSA) may be approved for this study. The trial is presently enrolling around 46 participants." - Anonymous Online Contributor
Could this treatment prove detrimental to the wellbeing of participants?
"The safety of this therapeutic intervention has been evaluated and deemed a 2, as the trial is in Phase 2; which suggests that there are some data supporting its security but none demonstrating its utility." - Anonymous Online Contributor
What are the purposes of this investigation?
"Over a two-week period, the researchers aim to track and assess Apnea Hypopnea Index (AHI) as well as measure sleep disturbance using Patient-Reported Outcomes Measurement Information System's Sleep Disturbance Assessment scale with T-scores indicating levels of disruption. Additionally, they will evaluate Sleep Related Impairment (SRI) via PROMIS 8 item instrument also scored on T-scale for comparative analysis against baseline values in US general population. Lastly, Epworth Sleepiness Scale is used to gauge likelihood of dozing off in various scenarios ranging from 0 to 3 points per activity summed up for an overall" - Anonymous Online Contributor
Is this research enrolling senior citizens?
"This trial is limited to individuals aged 18-50 years old. On the other hand, 48 medical studies are available for minors and 237 research opportunities exist for those over 65." - Anonymous Online Contributor
Are there any opportunities to join this experiment?
"Per the information posted on clinicaltrials.gov, this investigation is no longer recruiting individuals as it was last updated on November 14th 2022. However, 293 other studies are currently searching for volunteers to partake in them." - Anonymous Online Contributor