Abdominal Lavage for Resectable Pancreatic Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This randomized clinical trial studies how well high volume washing of the abdomen works in increasing survival after surgery in patients with pancreatic cancer that can be removed by surgery. High volume washings may remove free floating cancers present after surgery and help prolong survival in patients with pancreatic cancer.
Do I need to stop my current medications for this trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
How is abdominal lavage different from other treatments for resectable pancreatic cancer?
Abdominal lavage for resectable pancreatic cancer is unique because it involves washing out the abdominal cavity to check for cancer cells, which helps predict the patient's prognosis and guide treatment decisions. This approach is different from standard treatments that focus on directly removing or targeting the tumor itself.12345
What data supports the effectiveness of the treatment Abdominal Lavage for Resectable Pancreatic Cancer?
Peritoneal lavage has been shown to help decrease pain and amylase levels (an enzyme related to the pancreas) in patients with severe acute pancreatitis, although it did not improve survival rates significantly. However, its effectiveness in preventing complications or improving outcomes in pancreatic cancer surgery is not well-supported by current evidence.12367
Who Is on the Research Team?
Harish Lavu, MD
Principal Investigator
Thomas Jefferson University
Are You a Good Fit for This Trial?
This trial is for adults with suspected pancreatic or periampullary cancer who need surgery (pancreatectomy) and have no medical reasons to avoid it. Patients must be willing to be randomly assigned to different washing procedures after surgery. Those with benign tumors, other cancers within the last five years, or metastatic disease cannot join.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Surgery and Treatment
Patients undergo pancreaticoduodenectomy, distal pancreatectomy, or total pancreatectomy. Depending on the arm, they receive either EIPL-S lavage, EIPL-D lavage, or no lavage.
Follow-up
Participants are monitored for overall survival, disease-free survival, and complications every 3 months.
What Are the Treatments Tested in This Trial?
Interventions
- Lavage
Find a Clinic Near You
Who Is Running the Clinical Trial?
Sidney Kimmel Cancer Center at Thomas Jefferson University
Lead Sponsor
National Cancer Institute (NCI)
Collaborator