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Lipid Management Interventions for Cardiovascular Disease Risk

N/A

Recruiting

Led By Michael Farkouh, MD, FRCPC, FACC, FAHA

Research Sponsored by Institute for Clinical Evaluative Sciences

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 3 years

Awards & highlights

Study Summary

This trial aims to increase the use of cholesterol-lowering statin drugs to prevent heart attack and stroke in high-risk health regions across Ontario using a 'toolbox' of interventions.

Who is the study for?

This trial is for communities in Ontario with higher-than-average cardiovascular disease rates, a certain number of family physicians, and specific population sizes of adults aged 40-75. It's not for patients who already have established heart conditions.Check my eligibility

What is being tested?

The CHOICES study is testing how 'big data' can be used in clinical trials to improve cholesterol management using a toolbox of informational strategies aimed at both doctors and patients to prevent heart attacks and strokes.See study design

What are the potential side effects?

Since the interventions involve informational strategies rather than medications or procedures, traditional side effects are not applicable. However, there may be indirect effects on healthcare practices within the community.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 3 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~3 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Number of 66 -75 year old patients who filled a statin prescription

Secondary outcome measures

Incidence of Acute Myocardial Infarction (AMI), stroke or CVD death (major CVD outcome)

Incidence of Diabetes Mellitus (DM)

Cerebrovascular accident

+3 more

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Intervention ArmExperimental Treatment1 Intervention

The 14 communities that are in the intervention arm of the trial will receive a multicomponent intervention that provides both physicians and patients with access to a 'toolbox' of lipid management resources. The components planned for the 'toolbox' are all evidence-based interventions and chosen after consultations with Canadian family physicians and implementation science experts based on their potential for scalability to the entire population, cost and practicality. Online tools will be used and the trial will leverage pre-existing implementation initiatives (e.g., newsletters, listservs) wherever possible to minimize study costs and increase accessibility.

Group II: Control ArmActive Control1 Intervention

The 14 communities that are in the control arm of the trial will receive usual standard of care. The usual standard of care will follow clinical daily practice patterns provided by family physicians in Ontario for CVD prevention. This follows the periodic standard of care provided by Canadian cholesterol, hypertension, and diabetes best practice guideline recommendations utilized based on each physician's clinical judgement, physical assessment, and discretion. Patients also typically have access to existing cardiovascular prevention materials offered online through publicly available websites.

Do I qualify?Apply below to find out

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Who is running the clinical trial?

Heart and Stroke Foundation of OntarioOTHER

66 Previous Clinical Trials

331,925 Total Patients Enrolled

1 Trials studying Cardiovascular Risk

200,000 Patients Enrolled for Cardiovascular Risk

Heart & Stroke Richard Lewar Centres of Excellence in Cardiovascular ResearchUNKNOWN

The Ontario Spor Support UnitOTHER

5 Previous Clinical Trials

8,174 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any openings available in this clinical exploration for participants?

"According to the data available on clinicaltrials.gov, this medical experiment is currently seeking volunteers. The trial was initially made public on October 1st 2019 and has recently undergone an update as of August 24th 2021."

Answered by AI

How many people have signed up to participate in this clinical trial?

"Affirmative. The information on clinicaltrials.gov verifies that this experiment is actively recruiting subjects, having been first published October 1st 2019 and most recently updated on August 24th 2021. 500000 individuals need to be sourced from a single location for the trial's completion."

Answered by AI

Am I eligible to be a participant in this research?

"This health research is open to 500,000 individuals aged between 40 and 75 who suffer from cardiovascular diseases. It is essential that eligible candidates also come from a community with at least 5,000 inhabitants in the same age range, CVD rates higher than Ontario's average, 1,000 elderly people (66-75 years old) and 20-130 active family doctors."

Answered by AI