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Proton Beam Therapy

Proton Radiation Therapy for Brain Tumor

N/A

Recruiting

Led By Helen A Shih, MD

Research Sponsored by Massachusetts General Hospital

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Participants indicated for proton radiation therapy

Biopsy-proven benign or malignant brain tumor requiring tumor bed or tumor irradiation, including low-grade or favorable high-grade glioma, pituitary adenoma, vestibular schwannoma, and meningioma as common diagnoses

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 2 years

Awards & highlights

Study Summary

This trial is looking at whether or not proton radiation can be used to treat brain tumors.

Who is the study for?

Adults over 18 with benign or low-grade brain tumors who need radiation therapy can join this trial. They must be able to understand English, sign consent, use contraception if needed, and have a life expectancy of at least 6 months. People with severe illnesses, heart problems, psychiatric conditions that affect compliance, or pregnant/lactating women cannot participate.Check my eligibility

What is being tested?

The study is testing Proton Radiation as a treatment for various types of brain tumors including glioma, pituitary adenoma, schwannoma, and meningioma. It's designed to see how well it controls tumor growth while assessing the impact on patients' quality of life and any side effects.See study design

What are the potential side effects?

Proton Radiation may cause skin irritation at the treatment site, fatigue, headaches or hair loss in the treated area. Some people might experience nausea or difficulty with memory and concentration after treatment.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am recommended to undergo proton radiation therapy.

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I have a diagnosed brain tumor that needs radiation, such as glioma or meningioma.

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I am 18 years old or older.

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I can care for myself but may need occasional help.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 2 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~2 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Duration of Local Control

Secondary outcome measures

Alopecia

CD4 count

Neurocognitive effects

+6 more

Trial Design

1Treatment groups

Experimental Treatment

Group I: Proton RadiationExperimental Treatment1 Intervention

Radiation therapy will be delivered typically five (5) days per week on weekdays Proton Radiation dose be determine by histology

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Proton Radiation

2009

N/A

~170

0 / 4Eligibility criteria met

Find a Location

Who is running the clinical trial?

Massachusetts General HospitalLead Sponsor

2,933 Previous Clinical Trials

13,198,401 Total Patients Enrolled

Helen A Shih, MDPrincipal InvestigatorMassachusetts General Hospital

3 Previous Clinical Trials

167 Total Patients Enrolled

Media Library

Proton Radiation (Proton Beam Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT03286335 — N/A

Brain Tumor Research Study Groups: Proton Radiation

Brain Tumor Clinical Trial 2023: Proton Radiation Highlights & Side Effects. Trial Name: NCT03286335 — N/A

Proton Radiation (Proton Beam Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03286335 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the cap on enrollment for this research project?

"Affirmative. The data hosted on clinicaltrials.gov reveals that, with its original posting being made on September 26th 2018, this trial is still seeking participants. 1 medical site will be recruiting 100 patients in total for the study."

Answered by AI

Could you please provide information about the current enrolment status for this trial?

"As documented on clinicaltrials.gov, this trial is searching for suitable candidates to join their medical study; it was initiated in September 2018 and has been subsequently amended August 2020."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Local Control, Quality of Life and Toxicities in Adults With Benign or Indolent Brain Tumors Undergoing Proton Radiation Therapy

Helen A. Shih, MD 2018. "Local Control, Quality of Life and Toxicities in Adults With Benign or Indolent Brain Tumors Undergoing Proton Radiation Therapy". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03286335.

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