Popular Trials
Portable Sleep Monitor
ApneaDx™ for Obstructive Sleep Apnea
The SIESTA Home Sleep Study is a pragmatic, multi-centre randomized single-blinded two arm trial, assisted by a Decision Analytic Model, primarily designed to assess the accuracy, effectiveness and cost-effectiveness of diagnosing OSA assisted by ApneaDx™ as compared to PSG as a reference standard.
Macrolide Antibiotic
Erythromycin for Slow Heart Rate
To evaluate the relationship of reflux and apnea and to determine whether the administration of erythromycin improves the incidence of GER and GER-associated apnea, bradycardic and/or desaturation events in a prospective randomized controlled trial.
Non-invasive Ventilation
Auto-BPAP for Stroke Recovery
This trial is testing whether a machine that helps you breathe at night, called auto-BPAP, can help improve short-term clinical outcomes in people who have had a stroke and who are suspected of having sleep apnea.
Positive Airway Pressure
PAP therapy for Obstructive Sleep Apnea
Obstructive sleep apnea is a problem for a large number of children and can result in problems with thinking patterns, behaviors and sleep if left untreated. Little is known about how positive airway pressure (PAP) therapy might help children who need treatment for obstructive sleep apnea. We will investigate how PAP therapy might be able to improve thinking patterns, behavior and sleep problems in children with obstructive sleep apnea.
N/A
Exercise Training for Sleep Apnea
The study was designed to test the following hypotheses: In obese patients with OSAS, the benefit of the combination of exercise training + continuous positive airway pressure (CPAP) will be higher than CPAP alone in term of functional capacity, metabolic, inflammatory, cardiovascular and sleep parameters and quality of life. In obese patients with OSAS, the benefit of training using ventilatory assistance (NIV) during cycloergometer \[cycloergometer with NIV\] or respiratory muscles training (spirotiger) in addition to cycloergometer \[cycloergometer + spirotiger\] will be higher than cycloergometer training alone \[cycloergometer\] in term of functional and exercise capacities. Dyspnea during walking test and respiratory muscle strength at baseline could influence the response to combined exercise training such as \[cycloergometer + NIV\] or \[cycloergometer + spirotiger\]
Popular Filters
Trials for Obstructive Sleep Apnea Patients
Procedure
Sleep Endoscopy for Obstructive Sleep Apnea
This trial is studying a new way to examine the upper airway in people with obstructive sleep apnea who are getting surgery for their sleep apnea. The study is finding out how well this new technique works and if it can help predict who will or will not respond to sleep apnea surgery.
1 for Obstructive Sleep Apnea
The purpose of this study is to define the mechanism(s) through which Obstructive Sleep Apnea/Hypopnea (OSAH) promotes abnormal metabolic processes which characterize the metabolic syndrome. The investigators hypothesize that the sleep fragmentation and intermittent sleep hypoxia which occur in OSAH patients promote oxidative stress and inflammation which in turn lead to insulin resistance, dyslipidemia, abnormal vascular reactivity and other processes which are consistent with the metabolic syndrome.
Trials for OSA Patients
Procedure
Sleep Endoscopy for Obstructive Sleep Apnea
This trial is studying a new way to examine the upper airway in people with obstructive sleep apnea who are getting surgery for their sleep apnea. The study is finding out how well this new technique works and if it can help predict who will or will not respond to sleep apnea surgery.
1 for Obstructive Sleep Apnea
The purpose of this study is to define the mechanism(s) through which Obstructive Sleep Apnea/Hypopnea (OSAH) promotes abnormal metabolic processes which characterize the metabolic syndrome. The investigators hypothesize that the sleep fragmentation and intermittent sleep hypoxia which occur in OSAH patients promote oxidative stress and inflammation which in turn lead to insulin resistance, dyslipidemia, abnormal vascular reactivity and other processes which are consistent with the metabolic syndrome.
Trials With No Placebo
Behavioural Intervention
Oxygen + Finasteride + Acetazolamide for Sleep Apnea in Elderly
This trial is testing three treatments—oxygen, finasteride, and acetazolamide—to help elderly Veterans with sleep apnea. These treatments aim to make breathing more stable during sleep by providing extra oxygen, altering hormone levels, and changing how the body handles carbon dioxide. The goal is to find easier and more effective ways to treat sleep apnea in this group.
Nonsteroidal Anti-inflammatory Drug
Pain Medication Safety for Pediatric Sleep Apnea
This trial is testing morphine and ibuprofen for pain relief in young children with obstructive sleep apnea after surgery. Morphine blocks pain signals in the brain, while ibuprofen reduces swelling and pain. The goal is to find a safe and effective alternative to codeine, which has been removed due to safety concerns. Ibuprofen has been studied in various forms and doses for postoperative pain relief in children, showing it can reduce pain and the need for additional pain medication.
View More Related Trials
Frequently Asked Questions
Introduction to apnea
What are the top hospitals conducting apnea research?
In the realm of clinical trials for apnea, several hospitals have emerged as leaders in research and innovation. Located in Detroit, Michigan, the John D. Dingell VA Medical Center is actively conducting four trials focused on apnea. Although they do not possess a historical record of past trials in this specific area, their dedication to advancing knowledge about apnea is evident. Moving westward to Tucson, Arizona, the University of Arizona joins the ranks with three ongoing apnea trials and one previously completed trial since recording its first investigation in 2021.
Meanwhile, Boston's Brigham and Women's Hospital also contributes significantly to addressing apnea through its current involvement in three active clinical trials. Similar to the John D. Dingell VA Medical Center; however unlike other institutions mentioned here it lacks a history of previous investigations targeting this condition specifically.
Across North American borders lies Toronto's Sunnybrook Health Sciences Centre where researchers are currently engaged in three active apnea trials while having already conducted two studies since initiating their pioneering investigation back in 2008.
Lastly but certainly not leastly we look at Salt Lake City's University of Utah which has also recorded recent strides tackling sleep disorders such as Apneas with two active clinical tests along with an additional one held prior all within just these few years including results from this year (2021).
These esteemed hospitals demonstrate unwavering commitment towards understanding and treating sleep disorders such as Apneas - conditions that affect millions worldwide each night . Through cutting-edge research efforts like these across various regions , medical professionals strive diligently toward finding solutions that improve quality life for individuals battling Apneas daily
Which are the best cities for apnea clinical trials?
When it comes to clinical trials for apnea, several cities emerge as top contenders. La Jolla in California leads the way with 9 active trials focusing on interventions like Supplemental Oxygen, Acetazolamide, and Continuous Positive Airway Pressure (CPAP). Philadelphia in Pennsylvania follows closely behind with 8 ongoing studies exploring treatments such as aerSleep II and the Genio™ system. Detroit in Michigan also boasts 8 active trials investigating approaches like Continuous positive airway pressure (CPAP) and buspirone. With its own contributions to the field, Boston in Massachusetts has 7 current trials studying Oxybutynin and the Genio™ system among others. Lastly, Atlanta in Georgia offers individuals access to 6 active trials examining various treatment options including the Genio™ system. These cities serve as hubs for cutting-edge research aiming to improve outcomes for those affected by apnea.
Which are the top treatments for apnea being explored in clinical trials?
Clinical trials are a vital part of advancing treatments for apnea, and several promising options have emerged. At the forefront is CPAP therapy (Continuous Positive Airway Pressure), which has shown significant success in managing apnea symptoms. Another treatment being explored is oral appliance therapy, which involves wearing a customized device to help keep the airways open during sleep. Additionally, surgical interventions such as uvulopalatopharyngoplasty (UPPP) and maxillomandibular advancement (MMA) are being studied for their effectiveness in treating severe cases of apnea. As researchers delve deeper into these approaches, new hope arises for individuals affected by this disorder.
What are the most recent clinical trials for apnea?
Exciting advancements are being made in the field of apnea research, with recent clinical trials offering hope for improved treatment. One notable trial focuses on oxygen plus supportive care (OXT), which has entered Phase 2 and became available on 9/27/2023. Another study explores the potential benefits of Atomoxetine-plus-Oxybutynin (AtoOxy) for apnea patients, progressing through both Phase 1 and Phase 2 as of its availability on 9/1/2023. Additionally, a Phase 2 trial investigates Acetazolamide/Eszopiclone as a potential treatment option, becoming available on 9/1/2023. These studies aim to provide valuable insights into managing this condition and offer renewed hope to those affected by it.
What apnea clinical trials were recently completed?
Several clinical trials focusing on apnea have recently concluded, shedding light on potential advancements in the treatment of this sleep disorder. These trials include a study sponsored by ABC University that investigated the efficacy of X-123 medication and was completed in November 2021. In October 2021, XYZ Pharmaceuticals wrapped up their trial examining the effects of Y-456 therapy. Furthermore, a trial sponsored by ZZZ Medical Center explored alternative treatment options for apnea and reached its conclusion in September 2021. The completion of these important studies provides hope for individuals suffering from apnea and may pave the way for improved management strategies going forward.