Intervention group 1: Lower-body positive-pressure supported low-load treadmill walking exercise for Arthritis

Shirley Ryan AbilityLab, Chicago, IL
Arthritis+6 More ConditionsExercise for Knee Osteoarthritis -(LBPP supported low-load treadmill Walking) - Other
Eligibility
50 - 75
All Sexes
What conditions do you have?
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Study Summary

This trial will compare 3 exercise protocols to see how they affect knee pain & joint function in people with knee pathology.

Eligible Conditions
  • Arthritis
  • Musculoskeletal Disorders
  • Osteoarthritis of the Knee
  • Osteoarthritis
  • Rheumatic Diseases

Treatment Effectiveness

Phase-Based Effectiveness

1 of 3
N/A

Study Objectives

2 Primary · 11 Secondary · Reporting Duration: Baseline, and 30 minutes of walking within session and also as a comparison between day 0, week 4, and week 8

Week 8
Analysis of cardiovascular parameters
Change in Cardiometabolic (serum adiponectin) concentrations
Change in Cartilage oligomeric matrix protein (COMP) serum concentration
Change in Inflammatory cytokine (IL-1B) concentration
Change in Inflammatory cytokine (IL-6) concentration
Change in Inflammatory cytokine (TNF-A) concentration
Week 8
Function
Impact of Osteoarthritis on Quality of Life
Quality of life measured using the EQ5D survey
Symptoms
Week 8
Pain subscore on the Knee injury and Osteoarthritis Score (KOOS Survey)
Week 8
Questionnaire on Non-steroidal anti-inflammatory drugs (NSAID) use
Strength measure of the quadriceps and hamstring muscles

Trial Safety

Awards & Highlights

No Placebo Group
All patients enrolled in this trial will receive the new treatment.

Trial Design

3 Treatment Groups

Control group: Standard of care land-based walking exercise
1 of 3
Intervention group 1: Lower-body positive-pressure supported low-load treadmill ...
1 of 3
Intervention group 2: Aquatic Walking exercise
1 of 3

Active Control

Experimental Treatment

45 Total Participants · 3 Treatment Groups

Primary Treatment: Intervention group 1: Lower-body positive-pressure supported low-load treadmill walking exercise · No Placebo Group · N/A

Intervention group 1: Lower-body positive-pressure supported low-load treadmill walking exercise
Other
Experimental Group · 1 Intervention: Exercise for Knee Osteoarthritis -(LBPP supported low-load treadmill Walking) · Intervention Types: Other
Intervention group 2: Aquatic Walking exercise
Other
Experimental Group · 1 Intervention: Exercise for Knee Osteoarthritis - (Aquatic Walking) · Intervention Types: Other
Control group: Standard of care land-based walking exercise
Other
ActiveComparator Group · 1 Intervention: Exercise for Knee Osteoarthritis -(Land Based Treadmill or Community Walking) · Intervention Types: Other

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: baseline, and 30 minutes of walking within session and also as a comparison between day 0, week 4, and week 8

Who is running the clinical trial?

Shirley Ryan AbilityLabLead Sponsor
177 Previous Clinical Trials
13,788 Total Patients Enrolled
2 Trials studying Arthritis
52 Patients Enrolled for Arthritis
Northwestern UniversityOTHER
1,504 Previous Clinical Trials
866,667 Total Patients Enrolled
4 Trials studying Arthritis
1,046 Patients Enrolled for Arthritis
Prakash Jayabalan, MD, PhDPrincipal InvestigatorShirley Ryan AbilityLab
3 Previous Clinical Trials
118 Total Patients Enrolled
1 Trials studying Arthritis
28 Patients Enrolled for Arthritis

Eligibility Criteria

Age 50 - 75 · All Participants · 8 Total Inclusion Criteria

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Frequently Asked Questions

How many people have been enrolled in this experiment so far?

"Indeed, according to clinicaltrials.gov this trial is actively recruiting its participants. The initial posting of the study was on March 1st 2023 and it has been most recently updated on May 2nd 2023. 45 patients are being sought from a single medical site for enrolment in the experiment." - Anonymous Online Contributor

Unverified Answer

Is the age range for this clinical experiment limited to those over 35 years old?

"This medical trial is open to individuals aged 50 to 75. Meanwhile, there are 115 studies catering to those under 18 years old and 1082 investigations available for people above 65." - Anonymous Online Contributor

Unverified Answer

Could I potentially qualify to participate in this research?

"This scientific study is seeking 45 volunteer candidates who are 50-75 years old and exhibit symptoms of osteoarthritis." - Anonymous Online Contributor

Unverified Answer

Can individuals still join this clinical experiment?

"Based on the available data, this clinical trial is in a state of active recruitment. The study was initially posted to clinicaltrials.gov on March 1st 2023 and had its most recent update on May 2nd 2023." - Anonymous Online Contributor

Unverified Answer

What are the desired outcomes of this examination?

"The primary purpose of this investigation, which will be assessed between baseline and 8 weeks later, is to evaluate the Pain subscore on the Knee injury and Osteoarthritis Score (KOOS Survey). Secondary objectives encompass Functionality through KOOS subscales from day 0 up until week 8; Symptoms understood by means of KOOS's specified criteria over a similar period frame; as well as Impact of Osteoarthritis on Quality of Life determined by scores ranging from 0-100 with lower numbers denoting more severe issues." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.