buspirone for Sleep Apnea
This trial is investigating ways to better treat central sleep apnea, a breathing disorder which is common in patients with heart failure or those using pain medications. Current treatment for central sleep apnea is positive airway pressure therapy, which is not very effective. The goal of this proposal is to find new, better ways to treat central sleep apnea by testing combination therapies including positive airway pressure and a pharmacological agent. The investigators hope that the findings of this trial will help to improve treatment and quality of life for Veterans suffering from central sleep apnea.
- Sleep Apnea
Study ObjectivesOutcome measures can provide a clearer picture of what you can expect from a treatment.
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Frequently Asked Questions
What conditions or symptoms is buspirone typically employed to manage?
"Usually, salicylate poisoning is managed with the medication buspirone. Additionally, this pharmaceutical agent can be prescribed to address edema, open angle glaucoma (OAG), and other types of glaucoma."
Is buspirone accepted as a safe and efficacious therapeutic for humans?
"Based on the Phase 4 status of buspirone, our team at Power has assessed its safety as a 3. This classification indicates that this pharmaceutical is sanctioned for public use."
What objectives do investigators seek to accomplish with this research endeavor?
"Over the course of 4 months, researchers will be monitoring several indices to ascertain the primary outcome: carbon dioxide reserve. Secondary measurements include % stable breathing (VE/VT coefficient), carotid body function (ventilation in response to 100% oxygen), and controller gain (ventilatory response to end-tidal PCO2)."
What evidence exists for the efficacy of buspirone in other medical studies?
"Currently, 29 studies are being conducted to explore the medical efficacy of buspirone. 4 trials have reached Phase 3 and 43 sites throughout the United States are researching it, particularly in Silver Spring, Maryland."
Is this research endeavor currently recruiting participants?
"According to the information found on clinicaltrials.gov, this research endeavour is open for participation and has been since it was first posted in early July 2021; its latest update date being December 27th of that same year."
What is the scale of participation in this clinical trial?
"Affirmative. Clinicaltrials.gov verifies that this clinical trial is actively searching for participants; the initial post was made on July 1st, 2021 and recently updated on December 27th of the same year. Two hundred patients are sought from a single site."