← Back to Search

Behavioural Intervention

Continuous theta burst stimulation to the intraparietal sulcus for Post-Traumatic Stress Disorder

N/A

Recruiting

Led By Lily A Brown, PhD

Research Sponsored by University of Pennsylvania

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up days 4, 5, 34 and 35

Awards & highlights

Study Summary

"This trial will be the first to study the effects of continuous theta burst stimulation on a specific brain region in patients with posttraumatic stress disorder. The researchers aim to show that this stimulation can reduce arousal

Who is the study for?

This trial is for right-handed adults aged 18-60 with PTSD, as diagnosed by the DSM-5 criteria. Participants must not have any metal implants in their body.Check my eligibility

What is being tested?

The study tests if a brain stimulation technique called Continuous Theta Burst Stimulation (cTBS) to the Intraparietal Sulcus can reduce arousal symptoms in PTSD patients compared to sham (fake) treatment.See study design

What are the potential side effects?

Possible side effects of cTBS may include discomfort at the stimulation site, headache, lightheadedness, or temporary changes in thinking or mood.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ days 4, 5, 34 and 35

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~days 4, 5, 34 and 35

This trial's timeline: 3 weeks for screening, Varies for treatment, and days 4, 5, 34 and 35 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Electromyography startle response

Secondary outcome measures

Negative outcome expectancy

Subjective Units of Distress (SUDS)

fMRI

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Continuous theta burst stimulation to the intraparietal sulcusExperimental Treatment1 Intervention

Continuous theta burst stimulation will be delivered to the individually targeted intraparietal sulcus site at 100% RMT.

Group II: Sham continuous theta burst stimulationPlacebo Group1 Intervention

We will use the coil's electric stimulation functionality that allows for the delivery of a brief electric pulse to the scalp simultaneous to the pulse to mimic actual stimulation.

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University of PennsylvaniaLead Sponsor

2,009 Previous Clinical Trials

42,894,533 Total Patients Enrolled

Lily A Brown, PhDPrincipal InvestigatorUniversity of Pennsylvania

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this study include individuals older than 50 years of age as participants?

"To be considered for this trial, individuals must be between 18 and 60 years old."

Answered by AI

Who would be considered the ideal candidates to participate in this research investigation?

"In search of 120 individuals aged between 18 and 60 diagnosed with post-traumatic stress disorder, this clinical trial necessitates candidates to fulfill specific prerequisites: dominant use of the right hand, adulthood spanning from 18 to 60 years old, absence of metallic implants, compliance with Diagnostic and Statistical Manual of Mental Disorders (DSM-5) guidelines for PTSD as per the Clinician-Administered PTSD Scale designed for DSM-5 assessment."

Answered by AI

What is the current number of participants involved in this research trial?

"Indeed, the details outlined on clinicaltrials.gov specify that this particular research study is currently in search of suitable candidates. Originally published on April 4th, 2024, with the most recent update made on April 15th, 2024. The trial aims to recruit a total of 120 participants from one designated site."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

A Mechanistic Trial of the Neurobiology of Extinction Learning and Intraparietal Sulcus Stimulation

2024. "A Mechanistic Trial of the Neurobiology of Extinction Learning and Intraparietal Sulcus Stimulation". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06234969.

All > Ptsd New York