Automatic Positive Airway Pressure (APAP) for Manic Disorder

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
UCSD, La Jolla, CA
Manic Disorder+9 More
Automatic Positive Airway Pressure (APAP) - Device
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

Serious mental illnesses (SMI) like schizophrenia and bipolar disorder are two of the most disabling and costly chronic illnesses worldwide. A high proportion of adults with schizophrenia and bipolar disorder have sleep disorders, like obstructive sleep apnea (OSA), but tend to be underdiagnosed and undertreated compared to the general population. This study aims to examine feasibility, acceptance, and impact of OSA treatment and how it affects cognitive function in people with SMI.

Eligible Conditions

  • Manic Disorder
  • Sleep Apnea, Obstructive
  • Schizophrenia
  • Schizoaffective Disorder

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

5 Primary · 0 Secondary · Reporting Duration: 3 months

3 months
Acceptance of PAP trial
Cognitive Functioning
Monitoring Slow Wave Sleep and Sleep Spindle Density
OSA self-efficacy using the SEMSA
PAP usage

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Trial Design

1 Treatment Group

Automatic Positive Airway Pressure (APAP) device
1 of 1
Experimental Treatment

300 Total Participants · 1 Treatment Group

Primary Treatment: Automatic Positive Airway Pressure (APAP) · No Placebo Group · Phase 2

Automatic Positive Airway Pressure (APAP) device
Device
Experimental Group · 1 Intervention: Automatic Positive Airway Pressure (APAP) · Intervention Types: Device

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 3 months
Closest Location: UCSD · La Jolla, CA
Photo of La Jolla 1Photo of La Jolla 2Photo of La Jolla 3
1996First Recorded Clinical Trial
0 TrialsResearching Manic Disorder
51 CompletedClinical Trials

Who is running the clinical trial?

University of California, San DiegoLead Sponsor
1,007 Previous Clinical Trials
1,792,864 Total Patients Enrolled

Eligibility Criteria

Age 18+ · All Participants · 7 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
You have a diagnosis of schizophrenia, schizoaffective disorder, or bipolar disorder.
You are 40 to 70 years old.
You have not been conservatized.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.