300 Participants Needed

APAP for Obstructive Sleep Apnea in Mental Illness

AH
EL
SI
Overseen ByStephanie Ibrahim
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of California, San Diego
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

What is the purpose of this trial?

This trial is testing a treatment called Positive Airway Pressure (PAP) for adults with serious mental illnesses like schizophrenia and bipolar disorder who also have sleep apnea. PAP treatment uses a machine to help keep the airways open during sleep by providing a steady stream of air through a mask. The study aims to see if this treatment can improve cognitive function and overall health in these patients over several months. Positive Airway Pressure (PAP) is the standard and most effective treatment for obstructive sleep apnea (OSA).

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. However, if you are already receiving treatment for obstructive sleep apnea, you may not be eligible to participate.

What data supports the effectiveness of the treatment Automatic Positive Airway Pressure (APAP) for Obstructive Sleep Apnea in people with mental illness?

Research shows that treating obstructive sleep apnea (OSA) with Continuous Positive Airway Pressure (CPAP), which is similar to APAP, can improve cognitive function and reduce psychiatric symptoms in people with schizophrenia. This suggests that APAP might also help improve sleep and mental health in people with mental illness who have OSA.12345

Is APAP safe for treating obstructive sleep apnea in people with mental illness?

Continuous Positive Airway Pressure (CPAP), a similar treatment to APAP, has been shown to be safe and effective in treating obstructive sleep apnea in people with mental illness, improving sleep and cognitive function without major safety concerns.13678

How does the APAP treatment for obstructive sleep apnea in mental illness differ from other treatments?

APAP (Automatic Positive Airway Pressure) is a unique treatment for obstructive sleep apnea because it automatically adjusts the air pressure to the patient's needs throughout the night, unlike CPAP (Continuous Positive Airway Pressure) which provides a constant pressure. This can be particularly beneficial for individuals with mental illness, as it may offer a more comfortable and adaptable solution to managing their sleep apnea symptoms.12349

Eligibility Criteria

This trial is for adults aged 40-70 with serious mental illnesses like schizophrenia or bipolar disorder, who may also have or be at risk for obstructive sleep apnea. Participants should not have other major psychiatric conditions and must not be under conservatorship.

Inclusion Criteria

I am at risk for or have been diagnosed with obstructive sleep apnea.
I have been diagnosed with schizophrenia, schizoaffective disorder, or bipolar disorder.
You have never had a serious mental illness in your life.
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Timeline

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks
1 visit (in-person or at home)

Treatment

Participants receive a 3-month treatment with an automatic Positive Airway Pressure (PAP) device

12 weeks
Weekly check-ins (virtual or in-person), monthly detailed assessments

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

  • Automatic Positive Airway Pressure (APAP)
Trial OverviewThe study is testing the use of Automatic Positive Airway Pressure (APAP) machines to treat obstructive sleep apnea in individuals with serious mental illnesses, assessing how it might improve their cognitive function.
Participant Groups
1Treatment groups
Experimental Treatment
Group I: Automatic Positive Airway Pressure (APAP) deviceExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of California, San Diego

Lead Sponsor

Trials
1,215
Recruited
1,593,000+

References

Cognition in schizophrenia improves with treatment of severe obstructive sleep apnoea: A pilot study. [2020]
Treatment outcome of obstructive sleep apnea syndrome in a patient with schizophrenia: case report. [2017]
Obstructive Sleep Apnea Is Treatable With Continuous Positive Airway Pressure in People With Schizophrenia and Other Psychotic Disorders. [2022]
Neuropsychiatric manifestations of obstructive sleep apnea: a review. [2019]
[Treatment of psychiatric symptoms in schizophrenia spectrum disorders with comorbid sleep apnea syndrome: a case report]. [2013]
Screening for obstructive sleep apnoea in patients with serious mental illness. [2022]
Obstructive sleep apnea: management considerations in psychiatric patients. [2020]
Screening for obstructive sleep apnoea in high-risk patients with mood disorders. [2023]
Acute psychosis after CPAP treatment in a schizophrenic patient with sleep apnoea-hypopnoea syndrome. [2019]