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CPAP treatment for Depression

N/A
Waitlist Available
Led By Ruzica Jokic, MD
Research Sponsored by Queen's University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline and 6 weeks
Awards & highlights

Study Summary

The purpose of the study is to determine the effect on mood and anxiety symptoms of adding CPAP to the psychiatric treatment of patients with TRD (treatment resistant depression) and associated OSA (obstructive sleep apnea).

Eligible Conditions
  • Depression
  • Obstructive Sleep Apnea

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline and 6 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and 6 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Montgomery Asberg Depression Rating Scale (MADRS)
Secondary outcome measures
Beck Anxiety Inventory (BAI)
Epworth Sleepiness Score (ESS)
HAM-D21
+6 more

Side effects data

From 2008 Phase 2 trial • 68 Patients • NCT00047463
9%
skin irritation
5%
GI discomfort
5%
tachycardia or chest tightness
5%
nasal congestion
100%
80%
60%
40%
20%
0%
Study treatment Arm
Placebo Continuous Positive Airway Pressure
Continuous Positive Airway Pressure

Trial Design

3Treatment groups
Experimental Treatment
Active Control
Group I: CPAP treatmentExperimental Treatment1 Intervention
Continuous Positive Airway Pressure (CPAP)for 4 weeks
Group II: No CPAPActive Control1 Intervention
routine psychiatric care for 4 weeks followed by CPAP titration and initiation after followup measures.
Group III: Control groupActive Control1 Intervention
No obstructive sleep apnea detected.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
continuous positive airway pressure (CPAP)
2008
Completed Phase 4
~240

Find a Location

Who is running the clinical trial?

Queen's UniversityLead Sponsor
365 Previous Clinical Trials
120,297 Total Patients Enrolled
32 Trials studying Depression
7,033 Patients Enrolled for Depression
Ruzica Jokic, MDPrincipal InvestigatorQueen's University

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Treatment Resistant Depression and Obstructive Sleep Apnea, Effect of Continuous Positive Airway Pressure (CPAP)
Dr. Ruzica Jokic 2007. "Treatment Resistant Depression and Obstructive Sleep Apnea, Effect of Continuous Positive Airway Pressure (CPAP)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00441636.
All > Apnea > Sleep
~7 spots leftby Apr 2025
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