Eligibility
18+
All Sexes
What conditions do you have?
Select
Study Summary
The purpose of this research study is to see if obstructive sleep apnea (OSA) is associated with abnormalities in fat metabolism. Through this research study, the Investigator will evaluate how fat is metabolized in people with and without sleep apnea, what substances the fat tissue releases, and how these substances might change the way the body uses energy and sugar.
Eligible Conditions
- Metabolism Disorder, Lipid
- Obstructive Sleep Apnea (OSA)
Treatment Effectiveness
Effectiveness Progress
Other trials for Metabolism Disorder, Lipid
Study Objectives
1 Primary · 8 Secondary · Reporting Duration: Up to 3 months
Up to 3 months
Acute insulin response to glucose
Adipocyte insulin resistance
Free Fatty Acids (FFA) Oxidation Rate
Free fatty acid insulin sensitivity parameter
Free fatty acid rebound slope
Glucose effectiveness
Insulin sensitivity
Lipolysis suppression slope
Whole body lipolysis rate
Trial Safety
Safety Progress
Other trials for Metabolism Disorder, Lipid
Trial Design
3 Treatment Groups
No Intervention (Aim 1) Group
1 of 3
Lifestyle Intervention Only (Aim 2) Group
1 of 3
PAP Therapy and Lifestyle Intervention (Aim 2) Group
1 of 3
Active Control
Experimental Treatment
100 Total Participants · 3 Treatment Groups
Primary Treatment: PAP Therapy · No Placebo Group · N/A
Lifestyle Intervention Only (Aim 2) Group
Behavioral
Experimental Group · 1 Intervention: Lifestyle Counseling Intervention · Intervention Types: BehavioralPAP Therapy and Lifestyle Intervention (Aim 2) GroupExperimental Group · 2 Interventions: Lifestyle Counseling Intervention, PAP Therapy · Intervention Types: Behavioral, Device
No Intervention (Aim 1) GroupNoIntervention Group · 1 Intervention: No Intervention (Aim 1) Group · Intervention Types:
Trial Logistics
Trial Timeline
Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: up to 3 months
Closest Location: University of Miami · Miami, FL
1991First Recorded Clinical Trial
1 TrialsResearching Metabolism Disorder, Lipid
621 CompletedClinical Trials
Who is running the clinical trial?
University of MiamiLead Sponsor
780 Previous Clinical Trials
381,662 Total Patients Enrolled
National Heart, Lung, and Blood Institute (NHLBI)NIH
3,555 Previous Clinical Trials
46,915,089 Total Patients Enrolled
Naresh Punjabi, MDPrincipal InvestigatorUniversity of Miami
3 Previous Clinical Trials
275 Total Patients Enrolled
Eligibility Criteria
Age 18+ · All Participants · 2 Total Inclusion Criteria
Mark “yes” if the following statements are true for you:You are between the ages of 18 and 70 years.
You have the ability to give informed consent.\n
About The Reviewer
Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.
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