CPAP Therapy for Alzheimer's Disease
Trial Summary
What is the purpose of this trial?
Obstructive sleep apnea (OSA) is common in older adults and has recently been implicated in pathogenesis of Alzheimer's disease (AD). Research has shown that sleep disruptions have caused memory impairment. Sleep apnea is a form of sleep disruption. We would like to examine how obstructive sleep apnea may contribute to the progression of Alzheimer's disease.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. Please consult with the trial coordinators for more details.
What data supports the effectiveness of CPAP treatment for Alzheimer's disease?
Is CPAP therapy safe for use in humans?
How does CPAP treatment for Alzheimer's differ from other treatments?
CPAP (Continuous Positive Airway Pressure) treatment is unique for Alzheimer's patients as it addresses sleep-disordered breathing, which is common in these patients, by providing a steady flow of air to keep airways open during sleep. This treatment not only improves sleep quality but also helps slow cognitive decline and reduces daytime sleepiness, which are not typically targeted by standard Alzheimer's treatments.13457
Eligibility Criteria
This trial is for men and women aged 65-85 who live independently, can drive, have a MOCA score over 26, and either have obstructive sleep apnea (AHI ≥ 15/h) or do not. They must be non-smokers without neuromuscular disease, COPD, asthma, severe heart issues or uncontrolled hypertension. Participants cannot have contraindications to MRI scans.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either supplemental oxygen or PAP therapy for OSA over a 12-week period, with weekly adherence monitoring
Follow-up
Participants are monitored for safety and effectiveness after treatment, including neuroimaging and sleep assessments
Neuroimaging
MRI and PET scans to assess brain structure and function in relation to OSA and AD risk
Treatment Details
Interventions
- Continuous Positive Airway Pressure Machine
- Room Air
- Supplemental Oxygen
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, San Diego
Lead Sponsor