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Ischemic Conditioning for Stroke Recovery

N/A

Waitlist Available

Research Sponsored by Medical College of Wisconsin

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18-85 years of age

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up years 3-5

Awards & highlights

Study Summary

This trial will study how to reduce fatigue in stroke survivors' muscles to help them perform activities longer. They will use an intervention called ischemic conditioning to improve blood flow.

Who is the study for?

This trial is for English-speaking adults aged 18-85 who had a stroke at least 6 months ago and can consent to participate. It's not suitable for those with blood clot history, chronic pain that affects testing, recent heart attack, pregnancy, other neurological disorders or certain health conditions.Check my eligibility

What is being tested?

The study tests ischemic conditioning—a non-invasive method thought to improve blood flow and reduce muscle fatigue in the leg of stroke survivors. Researchers want to see if this intervention helps people post-stroke perform tasks longer without getting tired.See study design

What are the potential side effects?

While the description doesn't list specific side effects, ischemic conditioning generally involves restricting and then restoring blood flow which could cause discomfort or temporary numbness in the treated area.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am between 18 and 85 years old.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ years 3-5

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~years 3-5

This trial's timeline: 3 weeks for screening, Varies for treatment, and years 3-5 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Functional Sympatholysis Magnitude

Secondary outcome measures

Change in motor unit firing rates

Change in muscle metabolite accumulation

Change in muscle metabolite accumulation will include muscle pH

+1 more

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Ischemic ConditioningExperimental Treatment1 Intervention

Ischemic conditioning is a well-defined, non-invasive procedure which consists of inflating a blood pressure cuff around a limb (in our study, the paretic leg), inflating the cuff to 225 mmHg to occlude blood flow to the limb for 5 minutes, releasing the cuff for 5 minutes, and repeating 5 times. In our study, participants will receive six sessions of ischemic conditioning over the course of two weeks.

Group II: Ischemic Conditioning ShamPlacebo Group1 Intervention

There will also be an IC Sham group which is identical to the IC intervention, except the cuff will only be inflated to 10 mmHg, which is not a high enough pressure to occlude arterial blood flow.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Ischemic Conditioning

2019

N/A

~90

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Medical College of WisconsinLead Sponsor

610 Previous Clinical Trials

1,162,673 Total Patients Enrolled

17 Trials studying Stroke

1,390 Patients Enrolled for Stroke

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any age limitations on participation for this trial?

"This medical experiment will accept applicants aged 18 to 85."

Answered by AI

What criteria do individuals need to meet in order to be eligible for this trial?

"Possessors of stroke who are between 18 and 85 years old can register to be included in this trial, which has the capacity for around 40 participants."

Answered by AI

Are new participants being admitted for this research project?

"According to clinicaltrials.gov, the trial is not currently accepting new participants. The posting began on October 1st 2023 and was last updated on September 6th 2023; however, there are still 1120 other medical studies recruiting patients at this time."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Blood Flow Regulation and Neuromuscular Function Post-Stroke

Matthew J. Durand 2023. "Blood Flow Regulation and Neuromuscular Function Post-Stroke". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06027294.