Pramine

Nocturnal Enuresis (bedwetting), Bulimia Nervosa, Panic Disorder + 3 more
Treatment
20 Active Studies for Pramine

What is Pramine

ImipramineThe Generic name of this drug
Treatment SummaryImipramine, the prototypical tricyclic antidepressant (TCA), is a dibenzazepine-derivative TCA. TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, imipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, imipramine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as imipramine and amitriptyline, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline and desipramine. TCAs also block histamine H<sub>1</sub> receptors, &alpha;<sub>1</sub>-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively [A6584]. Imipramine has less sedative and anticholinergic effects than the tertiary amine TCAs, amitriptyline and clomipramine. Imipramine may be used to treat depression and nocturnal enuresis in children [FDA Label]. Unlabeled indications include chronic and neuropathic pain (including diabetic neuropathy), panic disorder, attention-deficit/hyperactivity disorder (ADHD), and post-traumatic stress disorder (PTSD) [L1349,L1348,A31900,L1351,L1352,L1353,A31904].
Tofranilis the brand name
Pramine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tofranil
Imipramine
1959
103

When to interrupt dosage

The proposed dosage of Pramine is contingent upon the diagnosed condition. The degree of dosage is dependent on the method of administration outlined in the table beneath.
Condition
Dosage
Administration
Neuropathic Pain
10.0 mg, , 75.0 mg, 100.0 mg, 125.0 mg, 150.0 mg, 50.0 mg, 25.0 mg, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Intramuscular, Injection, solution, Injection, solution - Intramuscular
Nocturnal Enuresis (bedwetting)
10.0 mg, , 75.0 mg, 100.0 mg, 125.0 mg, 150.0 mg, 50.0 mg, 25.0 mg, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Intramuscular, Injection, solution, Injection, solution - Intramuscular
Bulimia Nervosa
10.0 mg, , 75.0 mg, 100.0 mg, 125.0 mg, 150.0 mg, 50.0 mg, 25.0 mg, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Intramuscular, Injection, solution, Injection, solution - Intramuscular
Panic Disorder
10.0 mg, , 75.0 mg, 100.0 mg, 125.0 mg, 150.0 mg, 50.0 mg, 25.0 mg, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Intramuscular, Injection, solution, Injection, solution - Intramuscular
Depression
10.0 mg, , 75.0 mg, 100.0 mg, 125.0 mg, 150.0 mg, 50.0 mg, 25.0 mg, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Intramuscular, Injection, solution, Injection, solution - Intramuscular
Attention Deficit Hyperactivity Disorder
10.0 mg, , 75.0 mg, 100.0 mg, 125.0 mg, 150.0 mg, 50.0 mg, 25.0 mg, 25.0 mg/mL
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Intramuscular, Injection, solution, Injection, solution - Intramuscular

Warnings

Pramine Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Myocardial Infarction
Do Not Combine
There are 20 known major drug interactions with Pramine.
Common Pramine Drug Interactions
Drug Name
Risk Level
Description
Acepromazine
Major
Imipramine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Imipramine is combined with Aclidinium.
Alfuzosin
Major
Imipramine may increase the hypotensive activities of Alfuzosin.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Imipramine.
Amoxapine
Major
Imipramine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Amoxapine.

Pramine Novel Uses: Which Conditions Have a Clinical Trial Featuring Pramine?

Currently, there are no clinical trials evaluating the utility of Pramine for any particular condition.
Condition
Clinical Trials
Trial Phases
Attention Deficit Hyperactivity Disorder
64 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Phase 2, Phase 1
Nocturnal Enuresis (bedwetting)
1 Actively Recruiting
Not Applicable
Depression
330 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 4, Phase 3
Panic Disorder
11 Actively Recruiting
Not Applicable
Bulimia Nervosa
0 Actively Recruiting
Neuropathic Pain
4 Actively Recruiting
Not Applicable, Phase 1, Phase 2

Patient Q&A Section about pramine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How often can you take Pramin?

"It is best to take Pramin 30 minutes before nausea or vomiting is likely to occur, or 30 minutes before meals. doses of Pramin should be spaced evenly throughout the day, and it is only necessary to take Pramin when required for each occasion of nausea or vomiting."

Answered by AI

Does Pramin make you sleepy?

"Pramin could lead to drowsiness, dizziness, or lightheadedness for some individuals. If you experience any of these symptoms, do not operate any machinery or do anything else that could be harmful."

Answered by AI

What is the drug Paxlovid used for?

"Paxlovid is an oral antiviral pill that is taken at home to help keep high-risk patients from getting so sick that they need to be hospitalized."

Answered by AI

What is Pramine used for?

"Pramine 25 MG Tablet is an antidepressant medicine that is used to treat psychological conditions like obsessive-compulsive disorder, depression, and anxiety disorders like panic attacks. It is also used to treat muscle weakness associated with a sleep disorder called narcolepsy."

Answered by AI

Clinical Trials for Pramine

Have you considered Pramine clinical trials? We made a collection of clinical trials featuring Pramine, we think they might fit your search criteria.
Have you considered Pramine clinical trials? We made a collection of clinical trials featuring Pramine, we think they might fit your search criteria.
Have you considered Pramine clinical trials? We made a collection of clinical trials featuring Pramine, we think they might fit your search criteria.
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