rTMS + Tai Chi for Osteoarthritis
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores whether combining repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, with Tai Chi can effectively reduce knee pain and depression in people with osteoarthritis. The researchers aim to determine if targeting two brain areas with rTMS, alongside Tai Chi, provides more relief than Tai Chi alone. This trial suits individuals with chronic knee pain from osteoarthritis and moderate to severe depression, who can walk unaided and are willing to participate in Tai Chi sessions. Participants must have internet access for telehealth and no major health issues that would prevent safe exercise. As an Early Phase 1 trial, this research focuses on understanding how the treatment works in people, offering participants a chance to contribute to groundbreaking insights.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but it does require that you haven't changed your psychotropic or pain medications in the past four months. This means you should be stable on your current medications before joining the trial.
What prior data suggests that this rTMS technique is safe for treating knee osteoarthritis and depression?
Research has shown that repetitive transcranial magnetic stimulation (rTMS) is generally safe and well-tolerated. Studies have found that when combined with exercises like strengthening the thigh muscles, people with knee osteoarthritis did not report significant side effects. Many participants noticed improvements in pain and movement without major issues. Another study on a specific type of rTMS, called intermittent theta burst stimulation (iTBS), found that participants handled the treatment well, with no serious safety concerns.
For those considering joining a trial involving rTMS, these findings suggest that the treatment is likely safe. However, as with any medical treatment, individual reactions can vary, so discussing any concerns with the trial team is important.12345Why do researchers think this study treatment might be promising?
Researchers are excited about the use of repetitive transcranial magnetic stimulation (rTMS) and Tai Chi for osteoarthritis because these approaches offer a non-invasive alternative to standard pain management options like NSAIDs and corticosteroid injections. Unlike traditional treatments that primarily address symptoms, rTMS targets the brain's pain processing areas, potentially altering how pain is perceived. Meanwhile, Tai Chi promotes physical activity and joint flexibility without the strain of high-impact exercises. Together, these treatments could offer a holistic approach to managing osteoarthritis pain, reducing reliance on medications and their associated side effects.
What evidence suggests that this trial's treatments could be effective for knee osteoarthritis?
Research has shown that repetitive transcranial magnetic stimulation (rTMS) can help reduce pain in people with knee osteoarthritis. In this trial, participants may receive active rTMS treatment, which stimulates specific brain areas to lessen pain and enhance movement. Studies have found that targeting the brain area controlling movement with rTMS can effectively treat pain linked to knee osteoarthritis. Additionally, research indicates that high-frequency rTMS, combined with exercises for the thigh muscles, can improve pain and movement in those with knee osteoarthritis. While more research is needed, early findings suggest rTMS could be a promising option for managing knee osteoarthritis pain and related symptoms.23678
Are You a Good Fit for This Trial?
This trial is for individuals over 50 with knee osteoarthritis and persistent depression, who can walk unaided and are willing to attend Tai Chi sessions. They must have chronic pain, a high depression score, internet access for telehealth, and no recent medication changes or serious health conditions that would limit participation.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive rTMS treatment combined with Tai Chi intervention for knee OA pain and depression
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Repetitive Transcranial Magnetic Stimulation
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, Los Angeles
Lead Sponsor