Blephamide

Trachoma, Pink Eye, Conjunctivitis + 1 more
Treatment
4 Active Studies for Blephamide

What is Blephamide

SulfacetamideThe Generic name of this drug
Treatment SummaryPrednisolone acetate is a type of steroid medication that was approved by the FDA in 1955. It works by blocking certain chemical processes in the body to reduce inflammation and swelling.
Blephamideis the brand name
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Blephamide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Blephamide
Sulfacetamide
1961
61

Effectiveness

How Blephamide Affects PatientsPrednisolone acetate is a type of corticosteroid that works by blocking signals in the body that cause inflammation, and promoting signals that reduce inflammation. Its effects last for a few hours, and patients often take doses much higher than the body naturally produces. Taking corticosteroids can suppress the body's ability to respond to stress and make it more likely to get infections, so patients should be aware of these risks.
How Blephamide works in the bodyCorticosteroids can help reduce inflammation by decreasing blood vessel widening and the flow of white blood cells to sites of inflammation. They also change gene expression in the body, reducing the production of substances linked to inflammation and increasing substances that reduce inflammation. Low doses reduce inflammation, while higher doses can suppress your immune system. In high doses over an extended period, corticosteroids also cause sodium levels to rise and potassium levels to drop.

When to interrupt dosage

The prescribed dosage of Blephamide is contingent upon the determined condition, for example Ocular Infections, Irritations and Inflammations, Ocular Inflammation and Inflammatory Conditions. The quantity of dosage changes, in light of the technique of delivery (e.g. Ophthalmic or Solution/drops - Ophthalmic) featured in the table beneath.
Condition
Dosage
Administration
Trachoma
0.1 mg/mg, , 100.0 mg/mL, 0.098 mg/mg, 300.0 mg/mL, 80.0 mg/mL, 0.009 mg/mg, 0.9 mg/mL, 0.09 mg/mg, 1000.0 mg/mL, 10.0 mg/mL, 90.0 mg/mL, 10.0 %, 100.0 mg, 0.01 mg/mg, 0.095 mg/mg, 150.0 mg/mL, 98.0 mg/mL, 0.0286 mg/mg, 0.28 mg/mg, 0.08 mg/mg, 0.05 mg/mg, 0.15 mg/mg, 0.0098 mg/mg
, Ophthalmic, Ointment, Ointment - Ophthalmic, Suspension, Topical, Suspension - Topical, Solution, Solution - Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Aerosol, foam, Aerosol, foam - Topical, Solution / drops, Solution / drops - Ophthalmic, Solution - Ophthalmic, Liquid, Liquid - Topical, Swab, Swab - Topical, Cloth, Cloth - Topical, Rinse, Rinse - Topical, Gel, Gel - Topical, Kit, Suspension / drops, Suspension / drops - Ophthalmic, Soap, Soap - Topical, Liquid - Ophthalmic, Suspension - Ophthalmic, Shampoo, Shampoo - Topical, Emulsion, Emulsion - Topical, Ointment - Ophthalmic; Topical, Ophthalmic; Topical, Kit - Topical, Vaginal, Cream - Vaginal, Lotion / shampoo, Lotion / shampoo - Topical
Pink Eye
0.1 mg/mg, , 100.0 mg/mL, 0.098 mg/mg, 300.0 mg/mL, 80.0 mg/mL, 0.009 mg/mg, 0.9 mg/mL, 0.09 mg/mg, 1000.0 mg/mL, 10.0 mg/mL, 90.0 mg/mL, 10.0 %, 100.0 mg, 0.01 mg/mg, 0.095 mg/mg, 150.0 mg/mL, 98.0 mg/mL, 0.0286 mg/mg, 0.28 mg/mg, 0.08 mg/mg, 0.05 mg/mg, 0.15 mg/mg, 0.0098 mg/mg
, Ophthalmic, Ointment, Ointment - Ophthalmic, Suspension, Topical, Suspension - Topical, Solution, Solution - Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Aerosol, foam, Aerosol, foam - Topical, Solution / drops, Solution / drops - Ophthalmic, Solution - Ophthalmic, Liquid, Liquid - Topical, Swab, Swab - Topical, Cloth, Cloth - Topical, Rinse, Rinse - Topical, Gel, Gel - Topical, Kit, Suspension / drops, Suspension / drops - Ophthalmic, Soap, Soap - Topical, Liquid - Ophthalmic, Suspension - Ophthalmic, Shampoo, Shampoo - Topical, Emulsion, Emulsion - Topical, Ointment - Ophthalmic; Topical, Ophthalmic; Topical, Kit - Topical, Vaginal, Cream - Vaginal, Lotion / shampoo, Lotion / shampoo - Topical
Conjunctivitis
0.1 mg/mg, , 100.0 mg/mL, 0.098 mg/mg, 300.0 mg/mL, 80.0 mg/mL, 0.009 mg/mg, 0.9 mg/mL, 0.09 mg/mg, 1000.0 mg/mL, 10.0 mg/mL, 90.0 mg/mL, 10.0 %, 100.0 mg, 0.01 mg/mg, 0.095 mg/mg, 150.0 mg/mL, 98.0 mg/mL, 0.0286 mg/mg, 0.28 mg/mg, 0.08 mg/mg, 0.05 mg/mg, 0.15 mg/mg, 0.0098 mg/mg
, Ophthalmic, Ointment, Ointment - Ophthalmic, Suspension, Topical, Suspension - Topical, Solution, Solution - Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Aerosol, foam, Aerosol, foam - Topical, Solution / drops, Solution / drops - Ophthalmic, Solution - Ophthalmic, Liquid, Liquid - Topical, Swab, Swab - Topical, Cloth, Cloth - Topical, Rinse, Rinse - Topical, Gel, Gel - Topical, Kit, Suspension / drops, Suspension / drops - Ophthalmic, Soap, Soap - Topical, Liquid - Ophthalmic, Suspension - Ophthalmic, Shampoo, Shampoo - Topical, Emulsion, Emulsion - Topical, Ointment - Ophthalmic; Topical, Ophthalmic; Topical, Kit - Topical, Vaginal, Cream - Vaginal, Lotion / shampoo, Lotion / shampoo - Topical
Acne Vulgaris
0.1 mg/mg, , 100.0 mg/mL, 0.098 mg/mg, 300.0 mg/mL, 80.0 mg/mL, 0.009 mg/mg, 0.9 mg/mL, 0.09 mg/mg, 1000.0 mg/mL, 10.0 mg/mL, 90.0 mg/mL, 10.0 %, 100.0 mg, 0.01 mg/mg, 0.095 mg/mg, 150.0 mg/mL, 98.0 mg/mL, 0.0286 mg/mg, 0.28 mg/mg, 0.08 mg/mg, 0.05 mg/mg, 0.15 mg/mg, 0.0098 mg/mg
, Ophthalmic, Ointment, Ointment - Ophthalmic, Suspension, Topical, Suspension - Topical, Solution, Solution - Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Aerosol, foam, Aerosol, foam - Topical, Solution / drops, Solution / drops - Ophthalmic, Solution - Ophthalmic, Liquid, Liquid - Topical, Swab, Swab - Topical, Cloth, Cloth - Topical, Rinse, Rinse - Topical, Gel, Gel - Topical, Kit, Suspension / drops, Suspension / drops - Ophthalmic, Soap, Soap - Topical, Liquid - Ophthalmic, Suspension - Ophthalmic, Shampoo, Shampoo - Topical, Emulsion, Emulsion - Topical, Ointment - Ophthalmic; Topical, Ophthalmic; Topical, Kit - Topical, Vaginal, Cream - Vaginal, Lotion / shampoo, Lotion / shampoo - Topical

Warnings

Blephamide Contraindications
Condition
Risk Level
Notes
Chronic Kidney Disease (CKD)
Do Not Combine
There are 17 known major drug interactions with Blephamide.
Common Blephamide Drug Interactions
Drug Name
Risk Level
Description
Vibrio cholerae CVD 103-HgR strain live antigen
Major
The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Sulfacetamide.
Benzylpenicillin
Moderate
Sulfacetamide may decrease the excretion rate of Benzylpenicillin which could result in a higher serum level.
Estetrol
Moderate
The therapeutic efficacy of Estetrol can be decreased when used in combination with Sulfacetamide.
Insulin argine
Moderate
The risk or severity of hypoglycemia can be increased when Sulfacetamide is combined with Insulin argine.
Insulin aspart
Moderate
The risk or severity of hypoglycemia can be increased when Sulfacetamide is combined with Insulin aspart.
Blephamide Toxicity & Overdose RiskThe lowest toxic dose of prednisolone acetate in mice is 1680 mg/kg. Those who overdose onprednisolone acetate may experience more severe side effects of corticosteroids. If the overdose was recent, it can be treated with gastric lavage or inducing vomiting. Chronic overdosing can be managed by reducing the dose or administering the drug every other day. An overdose through eye drops is not expected to cause any problems.
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Blephamide Novel Uses: Which Conditions Have a Clinical Trial Featuring Blephamide?

189 active clinical trials are assessing the effectiveness of Blephamide in treating Inflammation, Inflammatory Conditions and Superficial Ocular Infections.
Condition
Clinical Trials
Trial Phases
Trachoma
1 Actively Recruiting
Phase 4
Acne Vulgaris
3 Actively Recruiting
Phase 1, Phase 2, Early Phase 1
Pink Eye
0 Actively Recruiting
Conjunctivitis
0 Actively Recruiting

Blephamide Reviews: What are patients saying about Blephamide?

5Patient Review
6/21/2014
Blephamide for Bacterial Infection of the Eyelid
I get awful allergies in the spring, and this is the only medication that has given me any relief.
4Patient Review
10/9/2009
Blephamide for Pink Eye from Bacterial Infection
Worked great for about a day, but then the redness came right back. It looks like I have acne on my eyelid now.
2.3Patient Review
9/17/2009
Blephamide for Inflammation of the Eye
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Patient Q&A Section about blephamide

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How do you use Blephamide ointment?

"When applying the medication, tilt your head back and look up. Squeeze the tube gently to place a 1/2 inch (1.3 centimeter) strip of ointment into the pouch created by pulling down your lower eyelid. Close your eyes gently for 1-2 minutes, rolling your eyeball in all directions to spread the medication."

Answered by AI

What is Blephamide used to treat?

"It will not work for other types of eye infections.

This medication is used to both prevent and treat eye infections, as well as to treat swelling in the eye. It contains sulfacetamide, an antibiotic that stops the growth of bacteria, and prednisolone, a corticosteroid that reduces inflammation. However, this medication will only work on bacterial eye infections, and not other types of eye infections."

Answered by AI

Is Blephamide a steroid?

"BLEPHAMIDE® ophthalmic suspension is a steroid/anti-infective combination drug that is indicated for treating steroid-responsive inflammatory ocular conditions when a corticosteroid is needed and when there is a risk of superficial bacterial ocular infection."

Answered by AI

What is the generic for Blephamide?

"There is no FDA-approved generic version of Blephamide available in the United States. Some online pharmacies may sell a counterfeit or unapproved version of the drug, which could be dangerous."

Answered by AI

Clinical Trials for Blephamide

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PF-07905428 for Acne

18 - 40
All Sexes
Montreal, Canada
The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called PF-07905428) for the potential treatment of acne vulgaris. This study is seeking participants who: * Are male or female between the ages of 18 and 40 * Are generally healthy * Are diagnosed with moderate to severe acne vulgaris (Cohort 4 only) The study medicine will be applied every day on the participant's face and/or back for 14 days (Cohorts 1 and 2) or for 28 days (Cohort 3 and 4). The investigators will compare the experiences of people receiving the study medicine to those of the people who do not. This will help the investigators determine if the study medicine is safe and effective. Participants will take part in this study for approximately 2 months. During this time, they will have 17 study visits (Cohorts 1 and 2) or 31 study visits (Cohorts 3 and 4) at the study clinic. The study team will also call participants once at the end of the study over the phone.
Phase 1
Waitlist Available
InnovaDerm (+2 Sites)Pfizer CT.gov Call CenterPfizer
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Isotretinoin vs Tetracycline for Acne

Any Age
All Sexes
Charleston, SC
In the effort to find better treatments for Moderate Acne, which often relies on long-term antibiotic use, researchers are exploring alternative options. While Isotretinoin, a Vitamin A derivative, is highly effective for severe acne, its side effects limit its use for milder cases. A recent study from our institution investigated a new approach: weekly Isotretinoin dosing. The results were promising, with acne improvement and no major side effects. This suggests that weekly Isotretinoin could be a successful alternative for moderate acne in both males and females. To validate these findings, investigators propose a randomized controlled trial comparing weekly Isotretinoin to daily Doxycycline over four months. This study could confirm the safety and effectiveness of weekly Isotretinoin, as well as shed light on patient satisfaction, and long-term results compared to standard antibiotics. This research may offer a breakthrough in treating moderate acne while addressing concerns about antibiotic overuse.
Phase < 1
Recruiting
Medical University of South CarolinaAlex Richmond, MD, MSCR
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