Zoloft

Bulimia Nervosa, Panic Disorder, Social Anxiety Disorder + 5 more
Treatment
10 FDA approvals
20 Active Studies for Zoloft

What is Zoloft

SertralineThe Generic name of this drug
Treatment SummarySertraline is a type of antidepressant medication called a selective serotonin reuptake inhibitor (SSRI). It works in a similar way to other SSRI drugs, such as Citalopram and Fluoxetine. It may take several weeks to start working and has fewer side effects than other types of antidepressant medications, such as drowsiness, dizziness, blurred vision, etc.
Sertraline Hydrochlorideis the brand name
image of different drug pills on a surface
Zoloft Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Sertraline Hydrochloride
Sertraline
1992
502

Approved as Treatment by the FDA

Sertraline, also known as Sertraline Hydrochloride, is approved by the FDA for 10 uses like Panic Disorder and Social Anxiety Disorder (SAD) .
Panic Disorder
Social Anxiety Disorder (SAD)
Post Traumatic Stress Disorder (PTSD)
Obsessive Compulsive Disorder (OCD)
Premenstrual Dysphoric Disorder (PMDD)
Social Anxiety Disorder
Depression
Post Traumatic Stress Disorder
Panic Disorder
Obsessive-Compulsive Disorder

Effectiveness

How Zoloft Affects PatientsSertraline is used to treat depression, OCD, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, and premenstrual dysphoric disorder by blocking the reabsorption of serotonin in the brain. Studies have found that it can help with mental clarity for those with depression. It does not have as strong of sedative, anticholinergic, or cardiovascular effects as other types of antidepressants. Generally, patients will start to feel the benefits after 4-6 weeks, although the reasons for this are not yet fully understood.
How Zoloft works in the bodySertraline works by blocking the reuptake of serotonin in the brain, which increases the amount of serotonin in the brain. This is thought to be what causes its antidepressant and anti-anxiety effects. In animal studies, it also seems to reduce the number of norepinephrine receptors. Sertraline does not interact with GABA, dopamine, or benzodiazepine receptors, but does have a weak interaction with norepinephrine and dopamine receptors. It also does not inhibit the action of the monoamine oxidase enzyme.

When to interrupt dosage

The proposed measure of Zoloft is contingent upon the diagnosed circumstance, including Social Anxiety Disorder, Obsessive-Compulsive Disorder and Post Traumatic Stress Disorder. The measure of dosage shifts, in accordance with the administration technique (e.g. Tablet, film coated or Concentrate) laid out in the table beneath.
Condition
Dosage
Administration
Bulimia Nervosa
, 100.0 mg, 50.0 mg, 25.0 mg, 150.0 mg, 200.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Tablet, extended release, Tablet, extended release - Oral
Panic Disorder
, 100.0 mg, 50.0 mg, 25.0 mg, 150.0 mg, 200.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Tablet, extended release, Tablet, extended release - Oral
Social Anxiety Disorder
, 100.0 mg, 50.0 mg, 25.0 mg, 150.0 mg, 200.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Tablet, extended release, Tablet, extended release - Oral
Obsessive-Compulsive Disorder
, 100.0 mg, 50.0 mg, 25.0 mg, 150.0 mg, 200.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Tablet, extended release, Tablet, extended release - Oral
Generalized Anxiety Disorder
, 100.0 mg, 50.0 mg, 25.0 mg, 150.0 mg, 200.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Tablet, extended release, Tablet, extended release - Oral
Depression
, 100.0 mg, 50.0 mg, 25.0 mg, 150.0 mg, 200.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Tablet, extended release, Tablet, extended release - Oral
Post Traumatic Stress Disorder
, 100.0 mg, 50.0 mg, 25.0 mg, 150.0 mg, 200.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Tablet, extended release, Tablet, extended release - Oral
Binge-Eating Disorder
, 100.0 mg, 50.0 mg, 25.0 mg, 150.0 mg, 200.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Solution, concentrate, Solution, concentrate - Oral, Concentrate, Concentrate - Oral, Tablet, extended release, Tablet, extended release - Oral

Warnings

Zoloft has five established contraindications. Therefore, it should not be taken conjointly with any of the conditions in the table below.Zoloft Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Sertraline may interact with Pulse Frequency
There are 20 known major drug interactions with Zoloft.
Common Zoloft Drug Interactions
Drug Name
Risk Level
Description
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
Major
The risk or severity of serotonin syndrome can be increased when Sertraline is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Sertraline.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Sertraline.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Sertraline.
Azelastine
Major
Sertraline may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Zoloft Toxicity & Overdose RiskThe lowest toxic dose of sertraline in rats is greater than 2000mg/kg according to the FDA. Common side effects of an overdose may include sleepiness, vomiting, rapid heartbeat, nausea, dizziness, restlessness, and shaking. Fatal overdoses involving sertraline alone are rare, but may be more likely when taken with other drugs. Serious conditions that can arise from an overdose on sertraline include serotonin syndrome, high or low blood pressure, fainting, stupor, coma, slow heartbeat, irregular heartbeats, confusion, and pancreatitis.
image of a doctor in a lab doing drug, clinical research

Zoloft Novel Uses: Which Conditions Have a Clinical Trial Featuring Zoloft?

Presently, 526 active clinical trials are underway to investigate the potential of Zoloft to alleviate Bulimia Nervosa, Premenstrual Dysphoric Disorder and Obsessive-Compulsive Disorder.
Condition
Clinical Trials
Trial Phases
Depression
210 Actively Recruiting
Phase 3, Phase 2, Not Applicable, Phase 4, Phase 1, Early Phase 1
Generalized Anxiety Disorder
7 Actively Recruiting
Not Applicable, Phase 2, Phase 3
Post Traumatic Stress Disorder
236 Actively Recruiting
Not Applicable, Early Phase 1, Phase 3, Phase 4, Phase 2, Phase 1
Bulimia Nervosa
0 Actively Recruiting
Obsessive-Compulsive Disorder
66 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 1, Early Phase 1
Panic Disorder
13 Actively Recruiting
Not Applicable
Social Anxiety Disorder
15 Actively Recruiting
Not Applicable
Binge-Eating Disorder
2 Actively Recruiting
Phase 2, Not Applicable

Zoloft Reviews: What are patients saying about Zoloft?

5Patient Review
8/22/2022
Zoloft for Panic Disorder
This treatment really improved my quality of life. I was struggling with panic attacks and anxiety, but this medication helped me to overcome those hurdles.
5Patient Review
9/7/2022
Zoloft for Repeated Episodes of Anxiety
Zoloft has been an incredible help for my anxiety and depression. It only took two weeks for the side effects to wear off, and they were entirely tolerable. I actually miss the crazy dreams I had while taking it.
5Patient Review
10/26/2022
Zoloft for Repeated Episodes of Anxiety
It helped me understand and prevent my anxiety. I had been stuck in a maze for so long, and this treatment allowed me to see above it.
5Patient Review
11/8/2022
Zoloft for Panic Disorder
I was really amazed by how well this medication worked with no side effects for me. It took away all my anxiety and racing thoughts. I don't have nearly as many panic attacks now, and they're not as bad when I do have them.
3Patient Review
7/28/2022
Zoloft for Major Depressive Disorder
This treatment was helpful for a week and then stopped being effective.
2.7Patient Review
8/30/2022
Zoloft for Panic Disorder
I was really hoping this would work, and it did for a few days until I had an allergic reaction. If you're not allergic, then I say give it a try.
2.3Patient Review
10/14/2022
Zoloft for Posttraumatic Stress Syndrome
I didn't feel any effects while taking this medication, even after six months. And it's only been three years since I stopped taking it, but I don't remember much from that time period.
2.3Patient Review
11/6/2022
Zoloft for Depression
At first, this medication made me feel pretty good. But eventually it stopped working and made things 10 times worse. I was hospitalized because of the increase in irritability, suicidal ideation, and other problems. Would not recommend to anyone.
1Patient Review
8/15/2022
Zoloft for Depression
This medication was absolutely terrible. I experienced night sweats, paranoia, hallucinations, diarrhea, nausea, vomiting and panic attacks. This medication should be banned!
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about zoloft

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What does Zoloft do for anxiety?

"Zoloft is an antidepressant that is also known as a selective serotonin reuptake inhibitor, or SSRI. This type of medication works by slowing down the reabsorption of serotonin."

Answered by AI

How does Zoloft make you feel?

"When used as prescribed, Zoloft can help reduce anxiety and fear, as well as the compulsive urge to perform certain tasks. Additionally, it can improve sleep quality, appetite, and energy levels, and help people who are experiencing intrusive thoughts and panic attacks feel more interested in day-to-day life."

Answered by AI

What are the side effects of Zoloft?

"If you experience any of the following side effects, you should contact your doctor immediately: headache, nausea, diarrhea, dry mouth, increased sweating, feeling nervous, restless, fatigued, sleepy, or having trouble sleeping (insomnia)."

Answered by AI

Is Zoloft a strong medicine?

"Prozac is a selective serotonin reuptake inhibitor (SSRI) and Zoloft is a selective serotonin reuptake inhibitor (SSRI).

Zoloft is a prescription medication used to treat depression and other issues. It is a brand-name drug and is a selective serotonin reuptake inhibitor (SSRI)."

Answered by AI

Clinical Trials for Zoloft

Image of Baylor College of Medicine in Houston, United States.

Stepped Care Treatment for Anxiety

7 - 17
All Sexes
Houston, TX
Childhood anxiety disorders (CAD) are common and impairing. Family based cognitive behavioral therapy (CBT) is efficacious in treating CAD. Yet, many children do not receive care due to barriers such as limited provider availably, high treatment costs, and constrained family resources (e.g., time). To combat these barriers, other treatment methods have been developed. The stepped care treatment models maximize resources by providing low-intensity, low-cost interventions as a first time treatment, while stepping up care for those needing more intensive treatment. Specifically, a stepped care model for CAD that begins with a parent-focus intervention has great promise to deliver efficacious and cost-effective treatment without having to engage the child. While stepped care approaches show promise in treating CAD with comparable efficacy to standard CBT, there remains a large research-to-practice gap. The stepped care model for CAD that begins with a parent-focused intervention has yet been explored, and very little is known about intervention mediators that explain mechanisms of change. This research is being done to improve the reach and quality of services using a stepped care model, offering an affordable and practical solution to the widespread gap in youth mental health care.
Waitlist Available
Has No Placebo
Baylor College of Medicine
Image of Duke University School of Medicine in Durham, United States.

Cognitive Rehabilitation for Anger in TBI and PTSD

18+
All Sexes
Durham, NC
This randomized clinical trial will enroll 100 Veteran-family/friend dyads to test the efficacy of CALM in treating anger in TBI and PTSD. The investigators hypothesize that compared to an active control group, Veterans randomized to the CALM group will demonstrate: * Significantly larger decreases in anger dysregulation, impulsivity, and executive dysfunction. * Significantly larger improvements in social and adaptive functioning including less aggression. * Significantly larger reduction in PTSD symptoms and suicidal ideation. The study targets Veterans who experience difficulties with anger and impulsivity due to TBI and PTSD. These issues are common, with up to 38% of Veterans with TBI also having PTSD. These conditions often make it challenging for Veterans to control their emotions and interact successfully in social and work settings. Our research will test the CALM (Cognitive Applications for Life Management) mobile app, which helps Veterans manage their goals, remember important tasks, and improve their attention. Initial tests of CALM have shown it can reduce levels of anger and related issues in Veterans. The investigators will conduct a study with 100 pairings of Veterans and a family member or friend. These pairs will be randomly assigned to one of two groups: one using the CALM mobile platform and the other receiving brain health education. Both groups will use their assigned intervention for three months and will receive support through videoconference calls at the beginning, middle, and end of the program.
Waitlist Available
Has No Placebo
Duke University School of MedicineEric Elbogen
Have you considered Zoloft clinical trials? We made a collection of clinical trials featuring Zoloft, we think they might fit your search criteria.Go to Trials
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Integrated Treatment for PTSD and Chronic Pain

18+
All Sexes
New York, NY
Posttraumatic stress disorder (PTSD) occurs in approximately 7% of adults in the general population. PTSD greatly impacts quality of life and often co-occurs with other conditions such as chronic pain. Individuals with co-morbid PTSD and chronic pain demonstrate higher PTSD symptoms and pain (as well as greater anxiety, depression, disability, and opioid use) compared to those with only one of those conditions. Gold standard treatments exist for both PTSD (e.g., Prolonged Exposure; PE) and chronic pain (e.g., Cognitive Behavioral Therapy for Chronic Pain; CBT-CP) and are generally offered sequentially (i.e., one at a time for the condition that is most prominent). Treating these conditions separately may overlook their interconnected nature, which may reduce efficacy and increase dropout. Thus, there is a need for an intervention to target both simultaneously, which may be more effective and efficient than treating conditions sequentially. This is a single-arm pilot study to assess the feasibility and acceptability of an integrated treatment for adults with comorbid PTSD and chronic pain. The intervention consists of 12 90-minute virtual psychotherapy sessions scheduled twice per week. The treatment draws from modules in PE and CBT-CP including psychoeducation, exposure to feared/avoided situations and activities, processing of exposures, behavioral activation, breathing and relaxation techniques, sleep hygiene, symptom monitoring, and structured homework assignments. Baseline and post-treatment assessments will be conducted.
Waitlist Available
Has No Placebo
Weill Cornell MedicineJoAnn Difede, PhD
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Inhaled Cannabis for PTSD

18+
All Sexes
Cave Creek, AZ
The rationale for the use of inhalational cannabis to potentially treat PTSD symptoms is based on the many reports of cannabis attenuating PTSD symptom expression among individuals with PTSD, including veterans. Study MJP2 is intended to build off MJP-1 through use of a larger sample size, a parallel study design, and subjective bias mitigation methods to re-examine the use of inhaled high THC-containing cannabis versus placebo for management of PTSD symptoms in a U.S. Veteran sample. Together these studies are intended to provide valuable insights on the already widespread use of cannabis in individuals with PTSD, for which there is currently a lack of controlled evidence available reflective of this real-world use.
Phase 2
Waitlist Available
Scottsdale Research Institute
Image of VA Phoenix Healthcare System in Phoenix, United States.

Integrated Health Care for Post-Traumatic Stress Disorder

18+
All Sexes
Phoenix, AZ
The goal of this clinical trial is to determine whether which types of integrative care, meaning a combination of psychotherapy and mind-body interventions, lead to the most changes in functioning among Veterans with posttraumatic stress disorder (PTSD). The main aims are: 1. To evaluate the impact of integrative care approaches on functional outcomes among Veterans with PTSD. 2. To examine factors relevant to the implementation of integrated treatments for PTSD from the perspective of patients, providers and administrators in the VA Healthcare System. Participants will: 1. Complete assessments at the beginning of the study and 12- and 24-weeks later. 2. Engage in 12 weeks of integrated care, with the type being randomly assigned.
Waitlist Available
Has No Placebo
VA Phoenix Healthcare System (+4 Sites)
Have you considered Zoloft clinical trials? We made a collection of clinical trials featuring Zoloft, we think they might fit your search criteria.Go to Trials
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Transcranial Direct Current Stimulation for Depression

18 - 85
All Sexes
San Diego, CA
The investigators propose a single-arm, open-label study to evaluate the effectiveness, safety, tolerability and feasibility of at-home transcranial direct current stimulation (tDCS) as a treatment for depression, particularly in cases where patients have not responded well to traditional therapies. Treatment will be delivered over a 2-week period with daily weekday treatments i.e., five tDCS sessions, each lasting 20 minutes, spaced by approximately 20-minute inter-session intervals, for a total of three hours a day. Participants will self-administer treatment at home under direct remote supervision. Pre- and post- treatment neurophysiological biomarkers sessions will also be carried out. The study aims to examine changes in mood, brain activity, and related clinical outcomes before, during, and after treatment, with the goal to provide more information that can be used for future studies.
Recruiting
Has No Placebo
UCSD Interventional Psychiatry
Image of UCLA Semel Institute for Neuroscience and Human Behavior in Los Angeles, United States.

Deep Brain Stimulation for Anxiety Disorders

18 - 70
All Sexes
Los Angeles, CA
The goal of this clinical trial is to learn how people respond to fear-related experiences in a virtual reality (VR) environment. The study will also look at how brain activity and body responses are connected to learning and memory of fear. To do so, we recruit individuals who are already implanted with a Responsive Neurostimulator (RNS) device for the treatment of epilepsy. This research may help improve our understanding of anxiety disorders and how to better treat them in the future. The main questions it aims to answer are: 1) How do people learn to associate certain cues in VR with feelings of fear or safety? 2) What brain and body responses happen during fear learning? Participants will: 1) Wear a virtual reality headset and experience different environments and sounds, 2) Have their brain activity, heart rate, and sweating measured, and 3) Receive safe, mild electrical pulses through the RNS device during the study to help study fear learning. Participants will attend one or more study sessions, each lasting about 3-4 hours.
Waitlist Available
Has No Placebo
UCLA Semel Institute for Neuroscience and Human Behavior
Have you considered Zoloft clinical trials? We made a collection of clinical trials featuring Zoloft, we think they might fit your search criteria.Go to Trials
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