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AIR Therapy for Gulf War Syndrome (GWAIR Trial)

N/A
Recruiting
Led By Linda L Chao, PhD
Research Sponsored by University of California, San Francisco
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Meets the Kansas GWI and CDC Chronic Multisymptom Illness (CMI) case definitions
Male and female GW Veterans between the ages of 48-80 deployed to the Gulf Theater of operations as defined by 38 CFR 3.317
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from baseline to 1 week post-treatment (after 6 weeks).
Awards & highlights

GWAIR Trial Summary

This trial will test whether a sleep treatment can improve symptoms in Gulf War Veterans with Gulf War Illness.

Who is the study for?
This trial is for Gulf War Veterans aged 48-80 with Gulf War Illness (GWI) who have sleep disorders like insomnia and obstructive sleep apnea, confirmed by a doctor. Participants must meet specific GWI criteria, have internet at home, and not be involved in other trials or starting/stopping certain medications or therapies within the last month.Check my eligibility
What is being tested?
The study tests if a behavioral treatment called Apnea and Insomnia Relief (AIR) can improve sleep and other symptoms of GWI compared to just Sleep Education (SE). It's designed to see which method is more effective for veterans suffering from these conditions.See study design
What are the potential side effects?
Since the interventions involve behavioral treatments rather than medication, side effects may include discomfort due to changes in sleeping habits or frustration if immediate improvements are not seen. Physical side effects are unlikely.

GWAIR Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I meet the criteria for Gulf War Illness and Chronic Multisymptom Illness.
Select...
I am a Gulf War Veteran aged 48-80 and was deployed in the Gulf Theater.
Select...
I have been diagnosed with sleep apnea.

GWAIR Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from baseline to 1 week post-treatment (after 6 weeks).
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from baseline to 1 week post-treatment (after 6 weeks). for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Gulf War Illness Symptom Severity Index
Change in Positive Airway Pressure (PAP) Adherence
Positive Airway Pressure (PAP) Adherence
Secondary outcome measures
Insomnia Severity Index (ISI)

GWAIR Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Apnea and Insomnia Relief (AIR)Experimental Treatment1 Intervention
This treatment will be offered over six sessions. All appointments will be conducted via telehealth and will last 60 minutes. The main components of the AIR protocol are (a) psychoeducation, (b) motivational interviewing, (c) PAP adherence strategies, and (d) cognitive behavioral therapy for insomnia (CBT-I).
Group II: Sleep Education (SE)Active Control1 Intervention
This treatment will be offered over six sessions. All appointments will be conducted via telehealth and will last 60 minutes. Topics covered include the sleep cycle, sleep across the lifespan, sleep and the mind, evening activities and the sleep environment, and daytime activities and sleep.

Find a Location

Who is running the clinical trial?

University of California, San FranciscoLead Sponsor
2,496 Previous Clinical Trials
11,933,809 Total Patients Enrolled
United States Department of DefenseFED
858 Previous Clinical Trials
225,541 Total Patients Enrolled
7 Trials studying Gulf War Syndrome
435 Patients Enrolled for Gulf War Syndrome
San Francisco VA Health Care SystemFED
9 Previous Clinical Trials
864,881 Total Patients Enrolled

Media Library

Apnea and Insomnia Relief (AIR) Clinical Trial Eligibility Overview. Trial Name: NCT05137743 — N/A
Gulf War Syndrome Research Study Groups: Sleep Education (SE), Apnea and Insomnia Relief (AIR)
Gulf War Syndrome Clinical Trial 2023: Apnea and Insomnia Relief (AIR) Highlights & Side Effects. Trial Name: NCT05137743 — N/A
Apnea and Insomnia Relief (AIR) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05137743 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this trial open to applicants aged 75 or younger?

"Enrollees for this medical research must be between 48 and 80 years old."

Answered by AI

What is the sample size of this research project?

"Affirmative. According to clinicaltrials.gov, this research study - which was first advertised on February 15th 2022- is currently recruiting participants. The aim of the trial is to enrol 80 patients from one medical centre."

Answered by AI

Is it possible for me to join this experiment?

"The eligibility requirements for this trial necessitate that participants suffer from Gulf War Illness and are between 48 to 80 years of age. The goal is to access a total of 80 suitable candidates."

Answered by AI

Are individuals currently able to enroll in this research project?

"Affirmative. According to clinicaltrials.gov, this trial that was originally posted on February 15th 2022 is still looking for participants and has been recently updated on March 1st of the same year. 80 patients are needed from a single medical centre."

Answered by AI
~38 spots leftby Feb 2026